Page last updated: 2024-09-02

bretazenil and flumazenil

bretazenil has been researched along with flumazenil in 26 studies

Compound Research Comparison

Studies
(bretazenil)
Trials
(bretazenil)
Recent Studies (post-2010)
(bretazenil)
Studies
(flumazenil)
Trials
(flumazenil)
Recent Studies (post-2010) (flumazenil)
1018144,673426981

Protein Interaction Comparison

ProteinTaxonomybretazenil (IC50)flumazenil (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0038
GABA theta subunitRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0038

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.69)18.7374
1990's17 (65.38)18.2507
2000's5 (19.23)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Battle, MR; Bouvet, DR; Brown, SL; Ewan, AL; Gaeta, A; Goggi, J; Guilbert, BB; Jackson, A; Jones, CL; Jones, PA; O'Shea, DM; Plant, SD; Trigg, W; Woodcraft, JL; Zheng, PH1
Facklam, M; Haefely, WE; Schoch, P1
Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P1
Gibert-Rahola, J; Maldonado, R; Micó, JA; Valverde, O1
Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M1
Di Scala, G; Rohmer, JG; Sandner, G1
Haefely, W1
Gallager, DW; Heninger, C; Hernandez, TD; Wilson, MA1
Acri, JB; Witkin, JM; Wong, G1
Bronson, ME1
Barber, DJ; Cooper, SJ1
Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A1
Hadingham, KL; Palmer, KJ; Thompson, SA; Wafford, KA; Whiting, PJ1
Besnard, F; Faure, C; Graham, D; Langer, SZ1
Acri, JB; Barrett, JE; Gleeson, S; Witkin, JM1
Benke, D; Michel, C; Mohler, H1
Macey, DJ; Miczek, KA; Weerts, EM1
Atack, JR; McKernan, RM; Smith, AJ1
Durant, F; Evrard, G; George, P; López-Romero, B; Sevrin, M1
Bergman, J; Paronis, CA1
Atack, J; Banks, G; Kelly, MD; Maubach, KA; Seabrook, GR; Smith, A; Whiting, PW; Wingrove, P1
Ator, NA; Griffiths, RR; Kaminski, BJ; Weerts, EM1
Atack, JR; Cook, SM; McKernan, RM; Pym, LJ; Rosahl, T1
Atack, JR; Cook, SM; Guiblin, A; McKernan, RM; Moyes, C; Pike, A; Pym, LJ; Rosahl, TW; Scott-Stevens, P; Sohal, B; Watt, AP1
Cook, JM; Groenink, L; Hansen, HH; Mirza, NR; Nielsen, EØ; Olivier, B; van Oorschot, R; Vinkers, CH1

Other Studies

26 other study(ies) available for bretazenil and flumazenil

ArticleYear
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.
    Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3

    Topics: Flumazenil; Fluorine Radioisotopes; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, GABA-A; Small Molecule Libraries

2013
Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Animals; Benzodiazepinones; Cell Membrane; Cerebral Cortex; Chlorides; Diazepam; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Rats; Receptors, GABA-A; Triazolam

1992
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Male; Mice; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Seizures; Triazolam

1992
Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice.
    Drug and alcohol dependence, 1992, Volume: 30, Issue:3

    Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Male; Mice; Morphine; Receptors, GABA-A; Substance Withdrawal Syndrome

1992
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
    Brain research, 1991, Aug-23, Volume: 557, Issue:1-2

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed

1991
Behavioral analysis of the effects of benzodiazepine receptor ligands in the conditioned burying paradigm.
    Behavioural brain research, 1990, Apr-16, Volume: 38, Issue:1

    Topics: Animals; Arousal; Benzodiazepinones; Brain; Carbolines; Conditioning, Classical; Diazepam; Dose-Response Relationship, Drug; Electroshock; Fear; Flumazenil; Grooming; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereotyped Behavior

1990
Partial agonists of the benzodiazepine receptor: from animal data to results in patients.
    Advances in biochemical psychopharmacology, 1988, Volume: 45

    Topics: Affinity Labels; Allosteric Site; Animals; Azides; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chlorides; Clonazepam; Diazepam; Drug Interactions; Ethanol; Flumazenil; Flurazepam; Humans; Ion Channels; Ligands; Models, Neurological; Neurons; Receptors, GABA-A

1988
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
    European journal of pharmacology, 1989, Nov-07, Volume: 170, Issue:3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain Chemistry; Diazepam; Drug Tolerance; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Seizures

1989
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors.
    European journal of pharmacology, 1995, May-24, Volume: 278, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Columbidae; Diazepam; Discrimination Learning; Flumazenil; GABA Modulators; Imidazoles; Male; Midazolam; Oxadiazoles; Radioligand Assay; Receptors, GABA-A; Sensitivity and Specificity; Stereoisomerism

1995
Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:2

    Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Flumazenil; Male; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome; Substance-Related Disorders

1994
The benzodiazepine receptor partial agonist bretazenil and the partial inverse agonist Ro 15-4513: effects on salt preference and aversion in the rat.
    Brain research, 1993, May-28, Volume: 612, Issue:1-2

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Flumazenil; Food Preferences; Male; Rats; Receptors, GABA-A; Saline Solution, Hypertonic; Sodium Chloride; Taste

1993
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psychological; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Imidazoles; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Seizures

1993
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.
    European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3

    Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Base Sequence; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Molecular Sequence Data; Pyrazoles; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid; Triazolam; Xenopus; Zolpidem

1995
Pharmacological profile of benzodiazepine site ligands with recombinant GABAA receptor subtypes.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1996, Volume: 6, Issue:2

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Line; Flumazenil; GABA Modulators; Humans; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazolam

1996
Blockade of behavioral effects of bretazenil by flumazenil and ZK 93,426 in pigeons.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:1

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Carbolines; Columbidae; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; Male; Midazolam; Punishment; Receptors, GABA

1997
GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ.
    Journal of neurochemistry, 1997, Volume: 69, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Cell Membrane; Cerebellum; Diazepam; Flumazenil; Immunohistochemistry; Immunosorbent Techniques; Macromolecular Substances; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins

1997
Dissociation of consummatory and vocal components of feeding in squirrel monkeys treated with benzodiazepines and alcohol.
    Psychopharmacology, 1998, Volume: 139, Issue:1-2

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Conditioning, Classical; Consummatory Behavior; Ethanol; Feeding Behavior; Flumazenil; Saimiri; Social Behavior; Vocalization, Animal

1998
Benzodiazepine modulation of recombinant alpha1beta3gamma2 GABA(A) receptor function efficacy determination using the Cytosensor microphysiometer.
    European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Biosensing Techniques; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Eukaryotic Cells; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pyridines; Receptors, GABA-A; Recombinant Proteins; Time Factors; Zolpidem

1998
Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil.
    Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:10

    Topics: Benzodiazepines; Benzodiazepinones; Binding Sites; Crystallography, X-Ray; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Imidazoles; Models, Molecular; Molecular Conformation; Molecular Structure

1998
Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Carbolines; Dose-Response Relationship, Drug; Electroshock; Feeding Behavior; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Kinetics; Male; Midazolam; Receptors, GABA-A; Reinforcement Schedule; Saimiri

1999
Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: Anticonvulsants; Arginine; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Cell Line; Cells, Cultured; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Histidine; Humans; Ligands; Mutation; Protein Subunits; Receptors, GABA-A

2002
Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboons.
    European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2

    Topics: Animals; Behavior, Animal; Benzodiazepinones; Dose-Response Relationship, Drug; Eating; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Infusions, Parenteral; Male; Papio; Psychomotor Performance; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam

2005
Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.
    British journal of pharmacology, 2005, Volume: 146, Issue:6

    Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Cerebellum; Flumazenil; Humans; Isotope Labeling; Ligands; Lorazepam; Male; Mice; Mice, Transgenic; Prosencephalon; Receptors, GABA-A; Receptors, GABA-B; Tritium

2005
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
    Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:6

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; GABA-A Receptor Agonists; Injections, Intravenous; Ligands; Male; Mice; Mice, Mutant Strains; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Triazines

2007
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Body Temperature; Brain; Diazepam; DNA Primers; Drug Tolerance; Flumazenil; Hypnotics and Sedatives; In Situ Hybridization; Male; Mice; Mice, Mutant Strains; Pyridazines; Pyridines; Receptors, GABA-A; Triazoles; Zolpidem

2012