brequinar has been researched along with uridine in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Handschumacher, RE; Lentz, SK; Pizzorno, G; Wiegand, RA | 1 |
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| de Kant, E; Laurensse, EJ; Nadal, JC; Peters, GJ; Pinedo, HM | 1 |
| Laurensse, EJ; Nadal, JC; Peters, GJ; Pinedo, HM; Schwartsmann, G; van der Vijgh, WJ; van Groeningen, CJ | 1 |
| Anderson, LW; Cysyk, RL; Strong, JM | 1 |
| Chen, SF; Dexter, DL; Ruben, RL | 1 |
| Buzaid, AC; Hait, WN; Marsh, JC; Murren, JR; Pizzorno, G; Poo, WJ; Ravikumar, TS; Strair, RK; Todd, M | 1 |
| Lemster, B; Starzl, TE; Tamura, K; Thomson, AW; Woo, J | 1 |
| Bakri, MT; Tamura, K; Thomson, AW; Woo, J | 1 |
| Cajulis, E; Chapman, F; Cosenza, C; Cramer, DV; Eiras-Hreha, G; Frankland, M; Hough, K; Mills, L; Wang, H; Zajac, I | 1 |
| Czech, J; Schorlemmer, HU; Schwab, W | 1 |
| Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X | 1 |
| Blinder, L; Chong, AS; Elder, RT; Finnegan, A; Gong, H; Sankary, H; Shen, J; Williams, JW; Xu, X; Yin, DP | 1 |
| Carrey, EA; Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Richards, DF; Rückemann, K; Simmonds, HA | 1 |
| Flao, KL; Francesconi, E; Hidden, H; Meakin, C; Millet, S; Ruuth, E; Spinella-Jaegle, S; Thomson, TA | 1 |
| Fey, V; Haapa-Paananen, S; He, T; Kallioniemi, O; Kaminskyy, VO; Kohonen, P; Perälä, M; Zhivotovsky, B | 1 |
| Peters, GJ | 1 |
| Chang, HY; Gong, MJ; Li, SF; Shao, JJ; Sun, YF; Zhang, YG | 1 |
| Alptekin, A; Ding, HF; Ding, J; Dong, Z; Yan, C; Yu, Y; Zha, Y; Zhu, S | 1 |
| Chang, H; Chen, Y; Guo, Y; Huang, Z; Song, Z; Sun, Y; Wei, Z; Zhang, G; Zheng, Z | 1 |
2 trial(s) available for brequinar and uridine
| Article | Year |
|---|---|
Biochemical modulation of 5-fluorouracil with brequinar: results of a phase I study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine | 1995 |
Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor.
Topics: Aged; Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Middle Aged; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Rats; Uridine | 2018 |
18 other study(ies) available for brequinar and uridine
| Article | Year |
|---|---|
Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Colonic Neoplasms; Digestive System; Drug Synergism; Female; Fluorouracil; Kidney; Kinetics; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Spleen; Thymidylate Synthase; Uracil Nucleotides; Uridine | 1992 |
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bone Marrow; Colonic Neoplasms; Dihydroorotate Oxidase; Female; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidoreductases; Pyrimidine Nucleotides; Uridine; Uridine Triphosphate | 1990 |
In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Oxidase; Dose-Response Relationship, Drug; Humans; Lymphocytes; Mice; Mice, Inbred BALB C; Neoplasms; Oxidoreductases; Reference Values; Uridine | 1990 |
Cellular pharmacology of DUP-785, a new anticancer agent.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Division; Cells, Cultured; Chromatography, Gas; Dihydroorotate Oxidase; Dose-Response Relationship, Drug; In Vitro Techniques; Leukemia L1210; Mass Spectrometry; Mice; Time Factors; Uridine | 1989 |
Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line; Cell Survival; Clone Cells; Cytidine; Dihydroorotate Oxidase; Humans; Pyrimidine Nucleotides; Uridine | 1986 |
The antilymphocytic activity of brequinar sodium and its potentiation by cytidine. Effects on lymphocyte proliferation and cytokine production.
Topics: Animals; Biphenyl Compounds; Cell Division; Cytidine; Cytidine Deaminase; Cytokines; Drug Synergism; Gene Expression; Kinetics; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Nucleotides; Signal Transduction; Stimulation, Chemical; Uridine | 1993 |
Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells.
Topics: B-Lymphocytes; Biphenyl Compounds; Cell Differentiation; Cell Line; Concanavalin A; Cytidine; DNA; Humans; Immunoglobulin M; Immunosuppressive Agents; Interleukin-6; Pyrimidines; Uridine | 1993 |
Correlation of the in vitro and in vivo immunosuppressive activity of brequinar sodium.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cyclosporine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Kinetics; Lymphocytes; Male; Pyrimidines; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Time Factors; Transplantation, Heterotopic; Uridine | 1993 |
Effect of malononitrilamides on human bone marrow.
Topics: Aniline Compounds; Biphenyl Compounds; Bone Marrow; Cell Survival; Cells, Cultured; Crotonates; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Hydroxybutyrates; Immunosuppressive Agents; Nitriles; Toluidines; Uridine | 1996 |
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Phosphorylation; Tyrosine; Uridine; Uridine Triphosphate | 1997 |
In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.
Topics: Animals; Biphenyl Compounds; Bone Marrow; Cells, Cultured; Drug Therapy, Combination; Growth Inhibitors; Immunosuppressive Agents; Injections, Intraperitoneal; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Phosphorylation; Spleen; Tyrosine; Uridine | 1998 |
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.
Topics: Adenosine Triphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Mice; Mitogens; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phytohemagglutinins; Pyrimidines; T-Lymphocytes; Uridine; Uridine Triphosphate | 1998 |
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sheep; Spleen; Toluidines; Uridine | 2002 |
Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Computational Biology; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Silencing; Humans; Mitochondria; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Uridine | 2014 |
Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Cell Death; Cell Line; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Myocardium; Swine; Uridine | 2019 |
Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma.
Topics: Animals; Biological Transport; Biphenyl Compounds; Carbazoles; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; Gene Amplification; Humans; Male; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nucleosides; Transcription, Genetic; Uridine | 2021 |
Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis.
Topics: African Swine Fever; African Swine Fever Virus; Animals; Dihydroorotate Dehydrogenase; Ferroptosis; Iron; Kinetics; Swine; Uridine; Virus Replication | 2023 |