Compounds > brequinar
Page last updated: 2024-08-24

brequinar and teriflunomide

brequinar has been researched along with teriflunomide in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's6 (31.58)29.6817
2010's7 (36.84)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Foti, A; Fruttero, R; Gasco, A; Giorgis, M; Lolli, ML; Tosco, P1
Janin, YL; Munier-Lehmann, H; Tangy, F; Vidalain, PO1
Guillou, S; Helynck, O; Janin, YL; Lucas-Hourani, M; Munier-Lehmann, H; Noel, A; Tangy, F; Vidalain, PO; Zanghi, G1
Coutant, EP; El Mazouni, F; Guillou, S; Harpon, J; Helynck, O; Janin, YL; Lucas-Hourani, M; Malmquist, NA; Munier-Lehmann, H; Noel, A; Phillips, MA; Scherf, A; Tangy, F; Vidalain, PO1
Al-Karadaghi, S; Andersson, M; Bonanni, D; Boschi, D; Buccinnà, B; Cignetti, A; Circosta, P; Ducime, A; Friemann, R; Gaidano, V; Giorgis, M; Goyal, P; Järvå, M; Lolli, ML; Lupino, E; Piccinini, M; Pippione, AC; Ramondetti, C; Rolando, B; Saglio, G; Sainas, S1
Calil, FA; Castilho, MS; Chiappetta, ERC; David, JS; Emery, FS; Fumagalli, F; Leite, FHA; Mello, RB; Nonato, MC1
Boschi, D; Lolli, ML; Pippione, AC; Sainas, S1
Aprile, S; Bhela, IP; Cordero-Sanchez, C; Cuzzocrea, S; Di Paola, R; Fusco, R; Genazzani, AA; Pirali, T; Purghè, B; Riva, B; Serafini, M1
Czech, J; Schorlemmer, HU; Schwab, W1
Jöckel, J; Löffler, M; Wendt, B1
Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD1
Clardy, J; Grossman, TH; Liu, S; Neidhardt, EA; Ocain, T1
Grossman, TH; Hedstrom, L; McLean, JE; Neidhardt, EA1
Albert, R; Andersen, E; Floersheim, P; Hungerford, V; Papageorgiou, C; Schreier, MH; Zurini, M1
Flao, KL; Francesconi, E; Hidden, H; Meakin, C; Millet, S; Ruuth, E; Spinella-Jaegle, S; Thomson, TA1
Baldwin, J; Farajallah, AM; Malmquist, NA; Phillips, MA; Rathod, PK1
Antal, T; Hansen, M; Johansson, E; Larsen, S; Le Nours, J; Löffler, M; Ullrich, A1
Coelho, AR; Oliveira, PJ1
Chadwick, AE; French, NS; Jones, SW; Park, BK; Penman, SL1

Reviews

2 review(s) available for brequinar and teriflunomide

ArticleYear
On dihydroorotate dehydrogenases and their inhibitors and uses.
    Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8

    Topics: Animals; Bacteria; Coccidia; Coccidiostats; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors

2013
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Animals; Anti-Infective Agents; Dihydroorotate Dehydrogenase; Drug Discovery; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrimidines

2019

Other Studies

17 other study(ies) available for brequinar and teriflunomide

ArticleYear
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Animals; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Halogenation; Isoxazoles; Leflunomide; Male; Microsomes, Liver; Mitochondria, Liver; Models, Molecular; Oxadiazoles; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar

2012
Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).
    Journal of medicinal chemistry, 2015, Jan-22, Volume: 58, Issue:2

    Topics: Antiviral Agents; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Structure-Activity Relationship

2015
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).
    Journal of medicinal chemistry, 2015, Jul-23, Volume: 58, Issue:14

    Topics: Antiviral Agents; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; HEK293 Cells; Humans; Inhibitory Concentration 50; Measles virus; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrazoles; Virus Replication

2015
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
    Journal of medicinal chemistry, 2018, Jul-26, Volume: 61, Issue:14

    Topics: Binding Sites; Cell Differentiation; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Humans; Jurkat Cells; Models, Molecular; Myeloid Cells; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Pyrazoles; Structure-Activity Relationship

2018
Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Animals; Anthelmintics; Dihydroorotate Dehydrogenase; Drug Design; Humans; Ligands; Oxidoreductases Acting on CH-CH Group Donors; Quinones; Schistosoma mansoni; Schistosomiasis mansoni; Structure-Activity Relationship

2019
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors.
    Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23

    Topics: Animals; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Cell Line; Dihydroorotate Dehydrogenase; Drug Discovery; Drug Stability; Enzyme Inhibitors; Humans; Male; Mice, Inbred C57BL; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Pancreatitis; Solubility; Structure-Activity Relationship; Triazoles

2020
Effect of malononitrilamides on human bone marrow.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Aniline Compounds; Biphenyl Compounds; Bone Marrow; Cell Survival; Cells, Cultured; Crotonates; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Hydroxybutyrates; Immunosuppressive Agents; Nitriles; Toluidines; Uridine

1996
Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria.
    Biochemical pharmacology, 1998, Oct-15, Volume: 56, Issue:8

    Topics: Aniline Compounds; Animals; Biphenyl Compounds; Crotonates; Dihydroorotate Dehydrogenase; Electron Transport; Hydroxybutyrates; Immunosuppressive Agents; Male; Mitochondria, Liver; Models, Molecular; NAD; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Oxygen Consumption; Rats; Rats, Wistar; Structure-Activity Relationship; Succinic Acid; Toluidines

1998
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay.
    Immunology letters, 1999, Apr-15, Volume: 67, Issue:3

    Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7

1999
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
    Structure (London, England : 1993), 2000, Jan-15, Volume: 8, Issue:1

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Binding Sites; Biphenyl Compounds; Catalytic Domain; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Growth Inhibitors; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Static Electricity; Toluidines

2000
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
    Biochemistry, 2001, Feb-20, Volume: 40, Issue:7

    Topics: Aniline Compounds; Antimycin A; Binding, Competitive; Biphenyl Compounds; Calorimetry; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Nitriles; Orotic Acid; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Substrate Specificity; Sulfonium Compounds; Titrimetry; Toluidines; Tryptophan

2001
Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Aniline Compounds; Animals; Antigens, Heterophile; B-Lymphocytes; Biphenyl Compounds; Cell Division; Crotonates; Cyclosporine; Drug Resistance; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphoma, B-Cell; Mycophenolic Acid; Nitriles; Primates; Pyrazoles; Swine; T-Lymphocytes; Toluidines; Transplantation, Heterologous; Tumor Cells, Cultured

2001
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
    Scandinavian journal of immunology, 2002, Volume: 56, Issue:1

    Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sheep; Spleen; Toluidines; Uridine

2002
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
    The Journal of biological chemistry, 2002, Nov-01, Volume: 277, Issue:44

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Binding Sites; Biphenyl Compounds; Catalysis; Cloning, Molecular; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Molecular Sequence Data; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Substrate Specificity; Toluidines; Ubiquinone

2002
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.
    Protein science : a publication of the Protein Society, 2004, Volume: 13, Issue:4

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Atovaquone; Biphenyl Compounds; Catalysis; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hydrogen Bonding; Hydroxybutyrates; Immunosuppressive Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Naphthoquinones; Nitriles; Orotic Acid; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Alignment; Substrate Specificity; Toluidines

2004
Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection.
    European journal of clinical investigation, 2020, Volume: 50, Issue:10

    Topics: Antiviral Agents; Betacoronavirus; Biphenyl Compounds; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Hydroxybutyrates; Leflunomide; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Pandemics; Pneumonia, Viral; Pyrimidines; SARS-CoV-2; Toluidines; Virus Replication

2020
Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 72

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Biphenyl Compounds; Cell Line; Cell Respiration; Crotonates; Dicarboxylic Acids; Dihydroorotate Dehydrogenase; Humans; Hydroxybutyrates; Immunosuppressive Agents; Leflunomide; Liver; Mitochondria; Models, Biological; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Salicylanilides; Toluidines; Triazoles

2021