brequinar has been researched along with pyrimidine in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Löffler, M | 1 |
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| Ardalan, K; Cleaveland, ES; Cooney, DA; Ford, H; Monks, A; Paull, K; Vaigro-Wolff, A; Zaharevitz, DW | 1 |
| Bakri, MT; Tamura, K; Thomson, AW; Woo, J | 1 |
| Flao, KL; Francesconi, E; Hidden, H; Meakin, C; Millet, S; Ruuth, E; Spinella-Jaegle, S; Thomson, TA | 1 |
| Bölker, M; Dietz, CD; Freymark, G; Löffler, M; Zameitat, E | 1 |
| Dong, H; Qing, M; Shi, PY; Wang, QY; Xu, HY; Yuan, Z; Zou, G | 1 |
| Damaso, CR; Schnellrath, LC | 1 |
| Fey, V; Haapa-Paananen, S; He, T; Kallioniemi, O; Kaminskyy, VO; Kohonen, P; Perälä, M; Zhivotovsky, B | 1 |
| Cao, S; Efstratiou, A; Igarashi, I; Kamyingkird, K; Mousa, AA; Nishikawa, Y; Salama, A; Tuvshintulga, B; Xuan, X; Yokoyama, N | 1 |
| Cuthbertson, CR; Han, Y; He, M; Madak, JT; Miyata, Y; Neamati, N; Petrunak, EM; Showalter, HD; Stuckey, JA; Sun, D; Tamura, S | 1 |
| Beytagh, MC; Bhutkar, A; Colón, CI; Drapkin, BJ; Dyson, NJ; Farago, AF; Hsu, PP; Jacks, T; Lewis, CA; Li, L; Li, Z; Mercer, KL; Muzumdar, MD; Myers, DT; Nabel, CS; Ng, SR; Phat, S; Romero, R; Vander Heiden, MG; Westcott, PMK | 1 |
| Barnes, S; Burma, S; Buszczak, M; Conacci-Sorrell, M; Han, J; Kanji, S; Kilgore, JA; Lafita-Navarro, MC; Venkateswaran, N; Williams, NS | 1 |
13 other study(ies) available for brequinar and pyrimidine
| Article | Year |
|---|---|
The "anti-pyrimidine effect" of hypoxia and brequinar sodium (NSC 368390) is of consequence for tumor cell growth.
Topics: Animals; Biphenyl Compounds; Cell Division; Cell Hypoxia; Cell Survival; Female; Flow Cytometry; Mice; Oxygen; Pyrimidines; Tumor Cells, Cultured | 1992 |
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.
Topics: Aminobiphenyl Compounds; Antineoplastic Agents; Binding Sites; Biphenyl Compounds; Cell Division; Dihydroorotate Dehydrogenase; Humans; Imidazoles; Naphthoquinones; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Software; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells.
Topics: B-Lymphocytes; Biphenyl Compounds; Cell Differentiation; Cell Line; Concanavalin A; Cytidine; DNA; Humans; Immunoglobulin M; Immunosuppressive Agents; Interleukin-6; Pyrimidines; Uridine | 1993 |
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sheep; Spleen; Toluidines; Uridine | 2002 |
Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.
Topics: Biphenyl Compounds; Cloning, Molecular; Dihydroorotate Dehydrogenase; DNA, Fungal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Gene Deletion; Gene Expression; Genetic Complementation Test; Humans; Mitochondria; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Protein Sorting Signals; Pyrimidines; Recombinant Proteins; Ustilago | 2007 |
Characterization of dengue virus resistance to brequinar in cell culture.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Chlorocebus aethiops; Dengue Virus; Drug Resistance, Viral; Pyrimidines; RNA, Viral; Vero Cells | 2010 |
Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Cell Line; Dihydroorotate Dehydrogenase; DNA Replication; Enzyme Inhibitors; Gene Expression Regulation; Kidney; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Vaccinia virus; Viral Proteins; Virus Replication | 2011 |
Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Computational Biology; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Silencing; Humans; Mitochondria; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Uridine | 2014 |
Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Biphenyl Compounds; Computational Biology; Dihydroorotate Dehydrogenase; Diminazene; Enzyme Inhibitors; Horse Diseases; Horses; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Mice; Molecular Weight; Oxidoreductases Acting on CH-CH Group Donors; Phylogeny; Plasmodium berghei; Pyrimidines; Theileria; Theileriasis | 2017 |
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Half-Life; HCT116 Cells; Humans; Hydrogen Bonding; Mice, Inbred Strains; Oxidoreductases Acting on CH-CH Group Donors; Pyridines; Pyrimidines; Quinolines; Solubility; Structure-Activity Relationship; Thermodynamics | 2018 |
Identification of DHODH as a therapeutic target in small cell lung cancer.
Topics: Adenocarcinoma; Animals; Biphenyl Compounds; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DCMP Deaminase; Dihydroorotate Dehydrogenase; Disease Progression; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Oxidoreductases Acting on CH-CH Group Donors; Pancreatic Neoplasms; Pyrimidines; Small Cell Lung Carcinoma; Survival Analysis; Xenograft Model Antitumor Assays | 2019 |
Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Nucleolus; Dihydroorotate Dehydrogenase; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Mice; Multienzyme Complexes; Nucleophosmin; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Ribosomes; RNA, Ribosomal; Stress, Physiological; Transcription, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |