Compounds > brequinar
Page last updated: 2024-08-24

brequinar and naphthoquinones

brequinar has been researched along with naphthoquinones in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Behrens, DL; Chen, SF; Papp, LM; Perrella, FW1
Ardalan, K; Cleaveland, ES; Cooney, DA; Ford, H; Monks, A; Paull, K; Vaigro-Wolff, A; Zaharevitz, DW1
Henseling, J; Knecht, W; Löffler, M1
Antal, T; Hansen, M; Johansson, E; Larsen, S; Le Nours, J; Löffler, M; Ullrich, A1
Peters, GJ1

Other Studies

5 other study(ies) available for brequinar and naphthoquinones

ArticleYear
Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
    Cancer research, 1992, Jul-01, Volume: 52, Issue:13

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Kinetics; Leukemia L1210; Mice; Naphthoquinones; Orotic Acid; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors

1992
Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.
    Biochemical pharmacology, 1995, Mar-30, Volume: 49, Issue:7

    Topics: Aminobiphenyl Compounds; Antineoplastic Agents; Binding Sites; Biphenyl Compounds; Cell Division; Dihydroorotate Dehydrogenase; Humans; Imidazoles; Naphthoquinones; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Software; Structure-Activity Relationship; Tumor Cells, Cultured

1995
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
    Chemico-biological interactions, 2000, Jan-03, Volume: 124, Issue:1

    Topics: Animals; Atovaquone; Benzoquinones; Binding, Competitive; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Naphthoquinones; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinones; Rats; Substrate Specificity

2000
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.
    Protein science : a publication of the Protein Society, 2004, Volume: 13, Issue:4

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Atovaquone; Biphenyl Compounds; Catalysis; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hydrogen Bonding; Hydroxybutyrates; Immunosuppressive Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Naphthoquinones; Nitriles; Orotic Acid; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Alignment; Substrate Specificity; Toluidines

2004
Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines.
    Nucleosides, nucleotides & nucleic acids, 2018, Volume: 37, Issue:6

    Topics: Amides; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Biphenyl Compounds; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma, Squamous Cell; Cell Line, Tumor; Dihydroorotate Dehydrogenase; Head and Neck Neoplasms; Humans; Isoxazoles; Naphthoquinones; Orotate Phosphoribosyltransferase; Oxidoreductases Acting on CH-CH Group Donors; Phosphonoacetic Acid; Purine Nucleotides; Pyrazoles; Pyrimidine Nucleotides; Ribonucleosides; Ribose

2018