brequinar has been researched along with leflunomide in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ; Hsieh, GC; Lane, B; Luly, JR; Marsh, K; Mollison, KW; Sheets, MP; Wang, AX; Xie, Q | 1 |
| Boschi, D; Lolli, ML; Pippione, AC; Sainas, S | 1 |
| Bouzriba, C; Fortin, S; Gagné-Boulet, M; Larcher, L | 1 |
| Kahan, BD | 1 |
| Antoniou, E; D'Silva, M; DeRoover, A; Howie, A; McMaster, P; Nishimura, Y | 1 |
| Halloran, PF | 1 |
| Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X | 1 |
| Antoniou, EA; Chondros, K; D'Silva, M; Howie, A; McMaster, P; Xu, M | 1 |
| Carrey, EA; Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Richards, DF; Rückemann, K; Simmonds, HA | 1 |
| Antoniou, EA; Chondros, K; D'Silva, M; Deroover, A; Howie, AJ; McMaster, P | 1 |
| Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD | 1 |
| Carrey, EA; Fairbanks, LD; Kirschbaum, B; Rückemann, K; Simmonds, HA; Swaminathan, R | 1 |
| Clardy, J; Grossman, TH; Liu, S; Neidhardt, EA; Ocain, T | 1 |
| Grossman, TH; Hedstrom, L; McLean, JE; Neidhardt, EA | 1 |
| Albert, R; Andersen, E; Floersheim, P; Hungerford, V; Papageorgiou, C; Schreier, MH; Zurini, M | 1 |
| Foti, A; Fruttero, R; Gasco, A; Giorgis, M; Lolli, ML; Tosco, P | 1 |
| Cao, S; Efstratiou, A; Igarashi, I; Kamyingkird, K; Mousa, AA; Nishikawa, Y; Salama, A; Tuvshintulga, B; Xuan, X; Yokoyama, N | 1 |
| Chen, S; Ding, S; Li, P; Pan, Q; Peppelenbosch, MP; Wang, W; Xu, L; Yin, Y | 1 |
| B, P; M, S; Swaminathan, P | 1 |
| Coelho, AR; Oliveira, PJ | 1 |
| Chadwick, AE; French, NS; Jones, SW; Park, BK; Penman, SL | 1 |
| Bai, J; Jin, L; Li, Y; Ma, XX; Ma, Z; Pu, F; Shang, Y; Wang, H; Zhang, D | 1 |
3 review(s) available for brequinar and leflunomide
| Article | Year |
|---|---|
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Topics: Animals; Anti-Infective Agents; Dihydroorotate Dehydrogenase; Drug Discovery; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrimidines | 2019 |
New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation.
Topics: Animals; Antimetabolites; Azathioprine; Biphenyl Compounds; Cell Differentiation; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Lymphokines; Oligonucleotides, Antisense; Polyenes; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; Tacrolimus | 1994 |
Molecular mechanisms of new immunosuppressants.
Topics: Amino Acid Isomerases; B-Lymphocytes; Biphenyl Compounds; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Isoxazoles; Leflunomide; Mycophenolic Acid; Oxidoreductases; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Polyenes; Purines; Pyrimidines; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus | 1996 |
19 other study(ies) available for brequinar and leflunomide
| Article | Year |
|---|---|
Synthesis and immunosuppressant activity of pyrazole carboxamides.
Topics: Animals; Biological Availability; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Pyrazoles; Rats; Structure-Activity Relationship; T-Lymphocytes | 1998 |
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
Topics: Benzenesulfonates; Cell Line, Tumor; Colorimetry; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Structure-Activity Relationship | 2020 |
Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506.
Topics: Animals; Biphenyl Compounds; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Histocompatibility Testing; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Spleen; Tacrolimus; Transplantation, Homologous | 1996 |
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Phosphorylation; Tyrosine; Uridine; Uridine Triphosphate | 1997 |
Combination treatment effectively intercepts advanced acute cardiac rejection.
Topics: Animals; Biphenyl Compounds; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Transplantation, Homologous; Transplantation, Isogeneic | 1997 |
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.
Topics: Adenosine Triphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Mice; Mitogens; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phytohemagglutinins; Pyrimidines; T-Lymphocytes; Uridine; Uridine Triphosphate | 1998 |
Immunosuppressive effect of combination schedules of brequinar with leflunomide or tacrolimus on rat cardiac allotransplantation.
Topics: Animals; Biphenyl Compounds; Drug Evaluation, Preclinical; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Postoperative Period; Rats; Rats, Inbred Lew; Tacrolimus; Transplantation, Homologous; Transplantation, Isogeneic | 1999 |
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1999 |
Simultaneous separation by high-performance liquid chromatography of carbamoyl aspartate, carbamoyl phosphate and dihydroorotic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Biphenyl Compounds; Carbamyl Phosphate; Chromatography, High Pressure Liquid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Orotic Acid; T-Lymphocytes | 1999 |
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Topics: Amino Acid Sequence; Aniline Compounds; Animals; Binding Sites; Biphenyl Compounds; Catalytic Domain; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Growth Inhibitors; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Static Electricity; Toluidines | 2000 |
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
Topics: Aniline Compounds; Antimycin A; Binding, Competitive; Biphenyl Compounds; Calorimetry; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Nitriles; Orotic Acid; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Substrate Specificity; Sulfonium Compounds; Titrimetry; Toluidines; Tryptophan | 2001 |
Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation.
Topics: Aniline Compounds; Animals; Antigens, Heterophile; B-Lymphocytes; Biphenyl Compounds; Cell Division; Crotonates; Cyclosporine; Drug Resistance; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphoma, B-Cell; Mycophenolic Acid; Nitriles; Primates; Pyrazoles; Swine; T-Lymphocytes; Toluidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
Topics: Animals; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Halogenation; Isoxazoles; Leflunomide; Male; Microsomes, Liver; Mitochondria, Liver; Models, Molecular; Oxadiazoles; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar | 2012 |
Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Biphenyl Compounds; Computational Biology; Dihydroorotate Dehydrogenase; Diminazene; Enzyme Inhibitors; Horse Diseases; Horses; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Mice; Molecular Weight; Oxidoreductases Acting on CH-CH Group Donors; Phylogeny; Plasmodium berghei; Pyrimidines; Theileria; Theileriasis | 2017 |
Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication.
Topics: Antiviral Agents; Biphenyl Compounds; Caco-2 Cells; Dihydroorotate Dehydrogenase; Drug Development; Enzyme Inhibitors; Humans; Leflunomide; Oxidoreductases Acting on CH-CH Group Donors; Primary Cell Culture; Pyrimidine Nucleosides; Rotavirus; Virus Replication | 2019 |
An in silico Workflow that Yields Experimentally Comparable Inhibitors for Human Dihydroorotate Dehydrogenase.
Topics: Biphenyl Compounds; Computer Simulation; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Humans; Leflunomide; Molecular Dynamics Simulation; Oxidoreductases Acting on CH-CH Group Donors; Workflow | 2020 |
Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection.
Topics: Antiviral Agents; Betacoronavirus; Biphenyl Compounds; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Hydroxybutyrates; Leflunomide; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Pandemics; Pneumonia, Viral; Pyrimidines; SARS-CoV-2; Toluidines; Virus Replication | 2020 |
Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Biphenyl Compounds; Cell Line; Cell Respiration; Crotonates; Dicarboxylic Acids; Dihydroorotate Dehydrogenase; Humans; Hydroxybutyrates; Immunosuppressive Agents; Leflunomide; Liver; Mitochondria; Models, Biological; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Salicylanilides; Toluidines; Triazoles | 2021 |
Inhibiting pyrimidine biosynthesis impairs Peste des Petits Ruminants Virus replication through depletion of nucleoside pools and activation of cellular immunity.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Enzyme Inhibitors; HEK293 Cells; Humans; Immunity, Cellular; Interferons; Leflunomide; Leukocytes, Mononuclear; Nucleosides; Peste-des-Petits-Ruminants; Peste-des-petits-ruminants virus; Pyrimidines; Uracil; Virus Replication | 2021 |