brequinar has been researched along with cyclosporine in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 38 (92.68) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Thomson, AW | 1 |
| Morris, RE | 1 |
| Chapman, FA; Cramer, DV; Hreha-Eiras, G; Jaffee, BD; Jones, EA; Knoop, M; Makowka, L | 1 |
| Aversa, G; Chang, CC; de Vries, JE; Punnonen, J; Yssel, H | 1 |
| Cramer, DV; Jaffee, BD; Jordan, S; Makowka, L; Moudgil, A; Toyoda, M; Wang, SJ | 1 |
| Surdacka, E; Surdacki, A; Sułowicz, W | 1 |
| Kahan, BD | 2 |
| Duquesnoy, RJ; Fung, JJ; Starzl, TE; Todo, S; Venkataramanan, R; Yao, GZ; Zeevi, A | 1 |
| Morris, RE; Murphy, MP | 1 |
| Chou, TC; Kahan, BD; Stepkowski, SM; Tu, Y | 2 |
| Chee, C; Chou, T; Kahan, BD; Stepkowski, S; Tejpal, N; Wang, M | 1 |
| Ferraresso, M; Kahan, BD; Knight, R; Stepkowski, SM; Tu, Y | 1 |
| Hiestand, P; Joergensen, J; Kuipers, H; Lardelli, P; Meerloo, T; Schreier, MH; Schuurman, HJ; White, DH | 1 |
| Bach, FH; Blakely, ML; Dalmasso, AP; Van der Werf, WJ | 1 |
| Chapman, FA; Cramer, DV; Makowka, L | 1 |
| Cajulis, E; Cosenza, CA; Cramer, DV; Eiras-Hreha, G; Makowka, L; Wang, HK | 2 |
| Barnett, M; Chapman, FA; Cramer, DV; Makowka, L; Wang, HK; Wu, GD; Yasunaga, C | 1 |
| Kahan, BD; Stepkowski, SM; Tu, Y; Wang, M | 1 |
| Fujino, Y; Hullett, DA; Kawamura, T; Sollinger, HW | 1 |
| Cajulis, E; Chapman, F; Cosenza, C; Cramer, DV; Eiras-Hreha, G; Frankland, M; Hough, K; Mills, L; Wang, H; Zajac, I | 1 |
| Allison, AC; Bechstein, WO; Hullett, DA; Kennedy, E; Kowalski, J; Smith, LS; Sollinger, HW; Steele, DM | 1 |
| Chou, TC; Gibbons-Stubbers, S; Kahan, BD; Stepkowski, S; Tejpal, N; Tu, Y; Wang, M | 1 |
| Kahan, BD; Stepkowski, SM | 1 |
| Areford, ML; Bollinger, RR; Collins, BH; Fabian, MA; Jaffee, BD | 1 |
| Chapman, FA; Cosenza, CA; Cramer, DV; Makowka, L; Middleton, YD; Tuso, PJ; Wu, GD | 1 |
| Barnes, TB; Campbell, P; Gayda, D; Zajac, I | 1 |
| Chou, TC; Kahan, BD; Qu, X; Stepkowski, SM; Wang, M | 1 |
| Halloran, PF | 1 |
| Alexander, JW; Levy, AE | 1 |
| Kahan, BD; Qu, X; Stepkowski, SM; Tian, L; Wang, M; Wang, ME; Yu, J | 1 |
| Joshi, AS; Kahan, BD; King, SY; Kornhauser, DM; Makowka, L; Menkis, AH; Schaefle, B; Sher, LS; Stiller, CR; Zajac, BA | 1 |
| Donatsch, P; Dorobek, B; Jaffee, B; Magolda, R; Pally, C; Papageorgiou, C; Schuurman, HJ; Smith, D; Zehender, H | 1 |
| Jaffee, BD; Pally, C; Schuurman, HJ; Tanner, M | 1 |
| Abraham, KI; Bartholomew, A; Boskovic, S; Colvin, RB; Cosimi, AB; Hong, HZ; Huang, C; Ko, DS; LeGuern, A; Poncelet, AJ; Sachs, DH; Wee, SL; Winn, HJ | 1 |
| Morris, RE; Sherwood, SW; Silva, HT; Slauson, SD | 1 |
| Bari, S; Groth, CG; Korsgren, O; Song, Z; Sundberg, B; Wennberg, L; Wijkström, M; Zhang, J | 1 |
| Albert, R; Andersen, E; Floersheim, P; Hungerford, V; Papageorgiou, C; Schreier, MH; Zurini, M | 1 |
8 review(s) available for brequinar and cyclosporine
| Article | Year |
|---|---|
The spectrum of action of new immunosuppressive drugs.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Polyenes; Sirolimus; Tacrolimus | 1992 |
Immunopharmacology of new xenobiotic immunosuppressive molecules.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Graft Rejection; Guanidines; Humans; Immunosuppressive Agents; Mycophenolic Acid; Polyenes; Ribonucleosides; Sirolimus; Tacrolimus; Xenobiotics | 1992 |
[New immunosuppressive drugs in transplantation].
Topics: Biphenyl Compounds; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Mycophenolic Acid; Polyenes; Ribonucleosides; Sirolimus; Spiro Compounds; Tacrolimus; Transplantation Immunology | 1994 |
New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation.
Topics: Animals; Antimetabolites; Azathioprine; Biphenyl Compounds; Cell Differentiation; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Lymphokines; Oligonucleotides, Antisense; Polyenes; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; Tacrolimus | 1994 |
Concentration-controlled immunosuppressive regimens using cyclosporine with sirolimus or brequinar in human renal transplantation.
Topics: Biphenyl Compounds; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Kidney Transplantation; Models, Theoretical; Polyenes; Sirolimus | 1995 |
Synergistic effects of cyclosporin analogs--A, D, G, IMM-125--with rapamycin and/or brequinar.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Cyclosporins; Drug Synergism; Humans; Immunosuppressive Agents; Lymphocyte Activation; Models, Biological; Polyenes; Sirolimus; Transplantation Immunology | 1994 |
The use of brequinar sodium for transplantation.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents | 1993 |
Molecular mechanisms of new immunosuppressants.
Topics: Amino Acid Isomerases; B-Lymphocytes; Biphenyl Compounds; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Isoxazoles; Leflunomide; Mycophenolic Acid; Oxidoreductases; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Polyenes; Purines; Pyrimidines; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus | 1996 |
1 trial(s) available for brequinar and cyclosporine
| Article | Year |
|---|---|
Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients.
Topics: Administration, Oral; Adult; Aged; Biphenyl Compounds; Cyclosporine; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Transplantation; Male; Middle Aged | 1997 |
32 other study(ies) available for brequinar and cyclosporine
| Article | Year |
|---|---|
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Dermatitis, Contact; Drug Therapy, Combination; Female; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppressive Agents; Kidney Transplantation; Liver Transplantation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred ACI; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Heterotopic; Transplantation, Homologous | 1992 |
Brequinar sodium, mycophenolic acid, and cyclosporin A inhibit different stages of IL-4- or IL-13-induced human IgG4 and IgE production in vitro.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Biphenyl Compounds; CD40 Antigens; Cells, Cultured; Cyclosporine; Cytokines; Humans; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Interleukin-13; Interleukin-4; Interleukins; Lymphocyte Activation; Mycophenolic Acid | 1993 |
Inhibition of in vitro immunoglobulin production by a novel immunosuppressive drug brequinar sodium.
Topics: Adult; Biphenyl Compounds; Cyclosporine; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Leukocytes, Mononuclear; Lymphocyte Activation; Pokeweed Mitogens; Tacrolimus | 1994 |
Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors.
Topics: Aspartic Acid; Biphenyl Compounds; Calcimycin; Cells, Cultured; Cyclosporine; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Lymphocytes; Mycophenolic Acid; Phosphonoacetic Acid; Ribonucleosides; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Models, Biological; Polyenes; Sirolimus; Tacrolimus; Transplantation, Homologous | 1993 |
The synergistic effects of cyclosporine, sirolimus, and brequinar on heart allograft survival in mice.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Female; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Models, Biological; Polyenes; Sirolimus | 1995 |
Synergistic interactions of cyclosporine, rapamycin, and brequinar on heart allograft survival in mice.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Female; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Polyenes; Sirolimus; Transplantation, Homologous | 1994 |
Triple combination of cyclosporine, brequinar, and rapamycin prolongs kidney allograft survival in the mongrel dog.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Dogs; Drug Synergism; Drug Therapy, Combination; Female; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Male; Polyenes; Sirolimus; Transplantation, Homologous | 1994 |
Vascular transplantation of Syrian hamster heart into Lewis rat: effect of brequinar, cyclosporine, cobra venom factor, and splenectomy.
Topics: Anastomosis, Surgical; Animals; Aorta, Abdominal; Biphenyl Compounds; Cricetinae; Cyclosporine; Elapid Venoms; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Male; Mesocricetus; Pulmonary Artery; Rats; Rats, Inbred Lew; Splenectomy; Transplantation, Heterologous; Transplantation, Heterotopic; Vena Cava, Inferior | 1994 |
Anti-B cell agents: suppression of natural antibodies and prolongation of survival in discordant xenografts.
Topics: Animals; Antibodies, Heterophile; Antibody Formation; B-Lymphocytes; Biphenyl Compounds; Cyclosporine; Graft Survival; Guinea Pigs; Immunosuppression Therapy; Immunosuppressive Agents; Mycophenolic Acid; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Splenectomy; Time Factors; Transplantation, Heterologous | 1994 |
The synergism of brequinar sodium and cyclosporine used in combination to prevent cardiac allograft rejection in the rat.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Lymphocyte Activation; Male; Rats; Rats, Inbred Lew | 1993 |
The prevention of accelerated cardiac allograft rejection in sensitized recipients after treatment with brequinar sodium.
Topics: Animals; Biphenyl Compounds; Cyclophosphamide; Cyclosporine; Graft Rejection; Graft Survival; Heart Transplantation; Immunization, Passive; Immunosuppressive Agents; Immunotherapy, Adoptive; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Skin Transplantation; Transplantation, Heterotopic; Transplantation, Homologous | 1993 |
Effect of cyclosporine alone or in combination with rapamycin and brequinar on survival of hamster heart xenograft in rats.
Topics: Animals; Biphenyl Compounds; Cricetinae; Cyclosporine; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Mesocricetus; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Transplantation, Heterologous | 1993 |
Evaluation of cyclosporine, mycophenolate mofetil, and Brequinar sodium combination therapy on hamster-to-rat cardiac xenotransplantation.
Topics: Animals; Antibody Formation; Biphenyl Compounds; Cricetinae; Cyclosporine; Cytotoxicity, Immunologic; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppression Therapy; Male; Mesocricetus; Mycophenolic Acid; Rats; Rats, Inbred Lew; Transplantation, Heterologous | 1994 |
Correlation of the in vitro and in vivo immunosuppressive activity of brequinar sodium.
Topics: Animals; Biphenyl Compounds; Cells, Cultured; Cyclosporine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Kinetics; Lymphocytes; Male; Pyrimidines; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Time Factors; Transplantation, Heterotopic; Uridine | 1993 |
Effects of immunosuppressive therapy on the rat aortic allograft model.
Topics: Animals; Aorta; Biphenyl Compounds; Cell Division; Cyclosporine; Immunosuppressive Agents; Male; Muscle, Smooth, Vascular; Mycophenolic Acid; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Transplantation, Homologous; Transplantation, Isogeneic | 1993 |
The synergistic interactions in vitro and in vivo of brequinar sodium with cyclosporine or rapamycin alone and in triple combination.
Topics: Antibodies; Biphenyl Compounds; CD3 Complex; Cell Line; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Culture Test, Mixed; Phytohemagglutinins; Polyenes; Sirolimus; T-Lymphocytes, Cytotoxic | 1993 |
Synergistic activity of the triple combination: cyclosporine, rapamycin, and brequinar.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Injections, Intravenous; Male; Polyenes; Rats; Rats, Inbred WF; Sirolimus; Transplantation, Homologous | 1993 |
Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Intestine, Small; Male; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1993 |
Evaluation of the use of brequinar sodium and cyclosporine combination therapy for preventing rat cardiac allograft rejection.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Lymphocyte Activation; Phytohemagglutinins; Rats; Rats, Inbred Lew; Stimulation, Chemical; Transplantation, Homologous | 1993 |
Prolonged xenograft survival following combination therapy with brequinar sodium and cyclosporine.
Topics: Animals; Biphenyl Compounds; Cricetinae; Cyclosporine; Graft Rejection; Graft Survival; Immunoglobulin M; Immunosuppressive Agents; Male; Mesocricetus; Rats; Rats, Inbred Lew; Transplantation, Heterologous | 1993 |
Toxicological and pharmacokinetic effects following coadministration of brequinar sodium and cyclosporine to Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Cyclosporine; Drug Evaluation, Preclinical; Drug Interactions; Female; Immunosuppressive Agents; Male; Rats; Rats, Sprague-Dawley | 1993 |
Beneficial effect of graft perfusion with anti-T cell receptor monoclonal antibodies on survival of small bowel allografts in rat recipients treated with brequinar alone or in combination with cyclosporine and sirolimus.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Biphenyl Compounds; Cyclosporine; Graft Survival; Graft vs Host Disease; Graft vs Host Reaction; Host vs Graft Reaction; Immune Tolerance; Immunosuppressive Agents; Intestine, Small; Male; Perfusion; Polyenes; Rats; Rats, Inbred ACI; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Antigen, T-Cell, alpha-beta; Sirolimus; Time Factors; Transplantation, Homologous | 1996 |
The significance of timing of additional short-term immunosuppression in the donor-specific transfusion/cyclosporine-treated rat.
Topics: Animals; Antilymphocyte Serum; Biphenyl Compounds; Blood Donors; Blood Transfusion; Cyclosporine; Drug Administration Schedule; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Methylprednisolone; Polyenes; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Sirolimus; Time Factors | 1996 |
Cytokine mRNA expression in tolerant heart allografts after immunosuppression with cyclosporine, sirolimus or brequinar.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Cytokines; Epitopes; Heart Transplantation; Immunosuppressive Agents; Interferon-gamma; Interleukins; Isoantigens; Lymphocyte Activation; Male; Polyenes; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; RNA, Messenger; Sirolimus; Th1 Cells; Th2 Cells | 1997 |
Side effects of brequinar and brequinar analogues, in combination with cyclosporine, in the rat.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Blood Cell Count; Body Weight; Bone Marrow; Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Immunosuppressive Agents; Jejunum; Leukopenia; Male; Rats; Rats, Inbred Lew; Spleen; Thrombocytopenia; Thymus Gland; Toxicity Tests; Weight Gain | 1998 |
Brequinar and brequinar analogues in rat allo- and xenotransplantation.
Topics: Animals; Biphenyl Compounds; Cricetinae; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Mesocricetus; Mycophenolic Acid; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Structure-Activity Relationship; Transplantation, Heterologous; Transplantation, Homologous | 1998 |
Demonstration of multilineage chimerism in a nonhuman primate concordant xenograft model.
Topics: Animals; Antibodies, Heterophile; Antilymphocyte Serum; Biphenyl Compounds; Combined Modality Therapy; Cyclosporine; Flow Cytometry; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Transfusion; Macaca fascicularis; Major Histocompatibility Complex; Papio; Spleen; Transplantation Chimera; Transplantation, Heterologous; Transplantation, Homologous; Whole-Body Irradiation | 1998 |
Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Biphenyl Compounds; Caproates; Crotonates; Cyclosporine; Dose-Response Relationship, Drug; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Male; Nitriles; Rats; Rats, Inbred Lew; Receptors, Interleukin-2; Receptors, OX40; Receptors, Tumor Necrosis Factor; Toluidines; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1999 |
Brequinar in combination with cyclosporine a inhibits islet xenograft rejection for up to 24 days: a study in the pig-to-rat model.
Topics: Animals; Biphenyl Compounds; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2000 |
Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation.
Topics: Aniline Compounds; Animals; Antigens, Heterophile; B-Lymphocytes; Biphenyl Compounds; Cell Division; Crotonates; Cyclosporine; Drug Resistance; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphoma, B-Cell; Mycophenolic Acid; Nitriles; Primates; Pyrazoles; Swine; T-Lymphocytes; Toluidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |