Compounds > brequinar
Page last updated: 2024-08-24

brequinar and atovaquone

brequinar has been researched along with atovaquone in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Janin, YL; Munier-Lehmann, H; Tangy, F; Vidalain, PO1
Calil, FA; Castilho, MS; Chiappetta, ERC; David, JS; Emery, FS; Fumagalli, F; Leite, FHA; Mello, RB; Nonato, MC1
Boschi, D; Lolli, ML; Pippione, AC; Sainas, S1
Chen, Q; Liu, H; Liu, X; Luo, Y; Qian, X; Sang, N; Su, N; Tao, L; Yu, Y; Zeng, T; Zhao, Y; Zhou, X; Zhou, Y; Zuo, Z1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Henseling, J; Knecht, W; Löffler, M1
Antal, T; Hansen, M; Johansson, E; Larsen, S; Le Nours, J; Löffler, M; Ullrich, A1
Cao, S; Efstratiou, A; Igarashi, I; Kamyingkird, K; Mousa, AA; Nishikawa, Y; Salama, A; Tuvshintulga, B; Xuan, X; Yokoyama, N1

Reviews

2 review(s) available for brequinar and atovaquone

ArticleYear
On dihydroorotate dehydrogenases and their inhibitors and uses.
    Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8

    Topics: Animals; Bacteria; Coccidia; Coccidiostats; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors

2013
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Animals; Anti-Infective Agents; Dihydroorotate Dehydrogenase; Drug Discovery; Enzyme Inhibitors; Humans; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrimidines

2019

Other Studies

6 other study(ies) available for brequinar and atovaquone

ArticleYear
Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Animals; Anthelmintics; Dihydroorotate Dehydrogenase; Drug Design; Humans; Ligands; Oxidoreductases Acting on CH-CH Group Donors; Quinones; Schistosoma mansoni; Schistosomiasis mansoni; Structure-Activity Relationship

2019
Bifunctional Naphtho[2,3-
    Journal of medicinal chemistry, 2020, 07-23, Volume: 63, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dihydroorotate Dehydrogenase; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Male; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, SCID; Molecular Docking Simulation; Molecular Structure; Naphthoquinones; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Rats, Sprague-Dawley; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Structure-Activity Relationship; Triazoles

2020
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
    Chemico-biological interactions, 2000, Jan-03, Volume: 124, Issue:1

    Topics: Animals; Atovaquone; Benzoquinones; Binding, Competitive; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Naphthoquinones; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinones; Rats; Substrate Specificity

2000
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.
    Protein science : a publication of the Protein Society, 2004, Volume: 13, Issue:4

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Atovaquone; Biphenyl Compounds; Catalysis; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hydrogen Bonding; Hydroxybutyrates; Immunosuppressive Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Naphthoquinones; Nitriles; Orotic Acid; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Alignment; Substrate Specificity; Toluidines

2004
Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
    Experimental parasitology, 2017, Volume: 176

    Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Biphenyl Compounds; Computational Biology; Dihydroorotate Dehydrogenase; Diminazene; Enzyme Inhibitors; Horse Diseases; Horses; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Mice; Molecular Weight; Oxidoreductases Acting on CH-CH Group Donors; Phylogeny; Plasmodium berghei; Pyrimidines; Theileria; Theileriasis

2017