bremazocine and u-50488

bremazocine has been researched along with u-50488 in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (48.00)	18.7374
1990's	33 (44.00)	18.2507
2000's	5 (6.67)	29.6817
2010's	1 (1.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Craft, RM; Dykstra, LA	2
Millan, MJ; Morris, BJ	1
al-Shireida, MF; el-Sharkawy, TY; Pilcher, CW	1
Muraki, T; Nomoto, T; Oike, N; Shibata, Y	1
Bianchi, G	1
Negus, SS; Picker, MJ; Powell, KR	1
Buydens, P; Finné, E; Govaerts, J; Matton, A; Vanhaelst, L	1
Dykstra, LA; Negus, SS; Picker, MJ	1
Brady, LS; Bykov, V; de Costa, BR; Jacobson, AE; Rice, KC; Rothman, RB	1
Band, L; Bykov, V; de Costa, BR; Jacobson, AE; Pert, A; Rice, KC; Rothman, RB	1
Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ	1
Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN	1
Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE	1
Bergman, J; Warren, PH	1
Craft, RM; Dykstra, LA; Picker, MJ	1
Makimura, M; Murakoshi, Y	1
Bykov, V; De Costa, BR; France, CP; Jacobson, AE; Rice, KC; Rothman, RB; Woods, JH	1
Bhargava, HN; Ramarao, P	1
Dykstra, LA; Picker, MJ	1
Bergman, J; Howell, LL; Morse, WH	1
Frey, HH	1
Dykstra, LA; Massie, CA	1
Barlow, JJ; Carroll, JA; Costello, GF; Main, BG; Shaw, JS	1
Bhargava, HN; Jablonski, HI; Ramarao, P; Rehder, KR	1
Bhargava, HN; Gulati, A	1
Frances, B; Meunier, JC; Moisand, C	1
Cooper, SJ; Jackson, A; Kirkham, TC	1
Ishihara, K; Iwama, T; Satoh, M; Takagi, H	2
Schmauss, C	1
De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A	1
Cooper, SJ; Jackson, A	2
Burks, TF; Hirning, LD; Porreca, F	1
Hayes, A; Kelly, A	1
Hayes, AG; Stewart, BR	1
Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR	1
Conway, S; Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM	2
Herz, A; Morris, BJ	1
Dunwiddie, TV; Johnson, KJ; Proctor, WR	1
Hart, JC; Leander, JD; Zerbe, RL	1
Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH	1
Dykstra, LA; Heise, JW; Picker, M	1
Leander, JD	2
Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE	1
Ramabadran, K	1
Altura, BM; Altura, BT; Quirion, R	1
Bidlack, JM; Joseph, DB; Lawrence, DM	1
Agmo, A; Contreras, JL; Paredes, RG	1
Collins, KA; Tseng, LF	1
Morgan, D; Picker, MJ	1
Brent, PJ	1
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ	1
Fowler, CJ; Tiger, G	1
Grandy, DK; Hirota, K; Hirst, RA; Lambert, DG	1
Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK	1
Fábián, G; Offermanns, S; Rottmann, M; Spicher, K; Szücs, M	1
Ingenito, AJ; Zhai, QZ	1
Childers, SR; Sim, LJ; Vogt, L; Xiao, R	1
Butelman, ER; Ko, MC; Woods, JH	1
Bian, JS; Wang, HX; Wong, TM; Wu, S; Yu, XC; Zhang, WM	1
De Vries, TJ; Homberg, JR; Mulder, AH; Nestby, P; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Holtzman, SG; Powell, KR	1
Lishmanov, YB; Maslov, LN; Ugdyzhekova, DS	1
Butelman, ER; Johnson, MD; Ko, MC; Mosberg, HI; Willmont, KJ; Woods, JH	1
Margotta, V; Merante, A; Palladini, G; Passarelli, F; Pontieri, FE; Venturini, G	1
De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L	1
Diao, CT; Lau, SY; Li, L; Wong, NS; Wong, TM	1
Barrett, AC; Cook, CD; Picker, MJ; Roach, EL; Syvanthong, C; Terner, JM	1
Flory, GS; Ko, MC; Lee, H; Willmont, KJ; Woods, JH	1
Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N	1

Reviews

1 review(s) available for bremazocine and u-50488

Article	Year
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia. Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response	1985

Article

Year

Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.

Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response

1985

Other Studies

74 other study(ies) available for bremazocine and u-50488

Article	Year
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination	1992
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors	1992
Inability of an opioid antagonist lacking negative intrinsic activity to induce opioid receptor up-regulation in vivo. British journal of pharmacology, 1991, Volume: 102, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Drinking; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Sensory Thresholds; Up-Regulation	1991
Vascular effects of some opioid receptor agonists. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Calcium Channel Blockers; Dinoprost; Endothelium, Vascular; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Narcotic Antagonists; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Vasodilation	1991
Analgesic effect of mu- and kappa-opioid agonists in beige and CXBK mice. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Acetic Acid; Analgesics; Animals; Benzodiazepines; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Benzomorphans; Dioxanes; Diuresis; Dose-Response Relationship, Drug; Idazoxan; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Yohimbine	1991
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation. Psychopharmacology, 1991, Volume: 103, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule	1991
The growth hormone secretory response to fentanyl in rat: an involvement of mu type receptors. Journal of endocrinological investigation, 1990, Volume: 13, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Leucine; Fentanyl; Growth Hormone; Male; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1990
Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure. Psychopharmacology, 1990, Volume: 102, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Pentobarbital; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Evidence for four opioid kappa binding sites in guinea pig brain. Progress in clinical and biological research, 1990, Volume: 328 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1990
Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands. Journal of medicinal chemistry, 1990, Volume: 33, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Chemical Phenomena; Chemistry; Cyclohexanes; Guinea Pigs; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Thiocyanates	1990
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex. European journal of pharmacology, 1990, Jun-08, Volume: 181, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei	1990
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats. Neuroscience, 1990, Volume: 37, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus	1990
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri	1989
Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Female; Morphine; Pyrrolidines; Receptors, Opioid	1989
Kappa-opioid agonists do not inhibit adenylate cyclase. Journal of pharmacobio-dynamics, 1989, Volume: 12, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Levorphanol; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rana catesbeiana; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride	1989
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes. European journal of pharmacology, 1989, Aug-29, Volume: 167, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzodiazepines; Benzomorphans; Binding, Competitive; Brain Chemistry; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Female; Guinea Pigs; Macaca mulatta; Male; Membranes; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism	1989
Effects of kappa-opioid receptor agonists and morphine on food intake and urinary output in food-deprived and nondeprived rats. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Dose-Response Relationship, Drug; Feeding Behavior; Food Deprivation; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors; Urination	1989
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Effects of levorphanol and several kappa-selective opioids on respiration and behavior in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Carbon Dioxide; Levorphanol; Macaca mulatta; Male; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Respiration	1988
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266. Pharmacology & toxicology, 1988, Volume: 62, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures	1988
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1988
A novel series of potent and selective agonists at the opioid kappa-receptor. European journal of pharmacology, 1988, Jul-14, Volume: 151, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1988
Effect of kappa-opioid receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats. European journal of pharmacology, 1988, Nov-01, Volume: 156, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Morphine; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Tail	1988
Cardiovascular responses to kappa opioid agonists in intact and adrenal demedullated rats. European journal of pharmacology, 1988, Nov-01, Volume: 156, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzomorphans; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Tape Recording	1988
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes. European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium	1985
Different effects of dynorphin A on in vitro guinea pig hippocampal CA3 pyramidal cells with various degrees of paired-pulse facilitation. Neuroscience letters, 1986, Jan-16, Volume: 63, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission	1986
Spinal kappa-opioid receptor-mediated antinociception is stimulus-specific. European journal of pharmacology, 1987, Jun-04, Volume: 137, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Dynorphins; Ethylketocyclazocine; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord	1987
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity. Journal of neuroscience research, 1987, Volume: 17, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid	1987
Observational analysis of the effects of kappa opioid agonists an open field behaviour in the rat. Psychopharmacology, 1988, Volume: 94, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Cyclazocine; Diuretics; Ethylketocyclazocine; Male; Motor Activity; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors	1988
Mu, but not kappa, opioid agonists induce contractions of the canine small intestine ex vivo. European journal of pharmacology, 1985, Feb-12, Volume: 109, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Dimethylphenylpiperazinium Iodide; Dogs; Ethylketocyclazocine; Gastrointestinal Motility; In Vitro Techniques; Intestine, Small; Morphine; Nalorphine; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1985
Profile of activity of kappa receptor agonists in the rabbit vas deferens. European journal of pharmacology, 1985, Apr-16, Volume: 110, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1985
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels. European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1985
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat. Neuropharmacology, 1985, Volume: 24, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa	1985
Effects of kappa opiate agonists on palatable food consumption in non-deprived rats, with and without food preloads. Brain research bulletin, 1985, Volume: 15, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Eating; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Satiety Response	1985
Opioid kappa receptors and the secretion of prolactin (PRL) and growth hormone (GH) in the rat. I. Effects of opioid kappa receptor agonists bremazocine and U-50,488 on secretion of PRL and GH: comparison with morphine. Neuroendocrinology, 1986, Volume: 42, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Growth Hormone; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors	1986
Opioid kappa receptors and the secretion of prolactin (PRL) and growth hormone (GH) in the rat. II. GH and PRL release-inhibiting effects of the opioid kappa receptor agonists bremazocine and U-50,488. Neuroendocrinology, 1986, Volume: 42, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Clonidine; Growth Hormone; Injections, Intravenous; Male; Morphinans; Morphine; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Serotonin; Time Factors	1986
Autoradiographic localization in rat brain of kappa opiate binding sites labelled by [3H]bremazocine. Neuroscience, 1986, Volume: 19, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1986
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus. British journal of pharmacology, 1987, Volume: 91, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Stimulation; Electrodes; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphinans; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1987
Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Butorphanol; Cyclazocine; Diuresis; Drinking; Ethylketocyclazocine; Female; Male; Nalorphine; Pyrrolidines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Vasopressins; Water Deprivation	1987
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail	1987
Possible mechanism involved in the inhibitory action of U-50, 488H, an opioid kappa agonist, on guinea pig hippocampal CA3 pyramidal neurons in vitro. Journal of pharmacobio-dynamics, 1987, Volume: 10, Issue:10 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neurons; Procaine; Pyramidal Tracts; Pyrrolidines; Tetrodotoxin; Veratrine	1987
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats. Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule	1987
Kappa opioid agonists and antagonists: effects on drinking and urinary output. Appetite, 1984, Volume: 5, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins	1984
Radioligands for probing opioid receptors. Journal of receptor research, 1984, Volume: 4, Issue:1-6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens	1984
Further study of kappa opioids on increased urination. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Morphinans; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination	1983
Hyperalgesic effect of the selective kappa opioid agonist, U-50488H in mice. Japanese journal of pharmacology, 1983, Volume: 33, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Male; Mice; Morphine; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1983
Identification of benzomorphan-kappa opiate receptors in cerebral arteries which subserve relaxation. British journal of pharmacology, 1984, Volume: 82, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cerebral Arteries; Cyclazocine; Dinoprost; Dogs; Drug Interactions; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phencyclidine; Prostaglandins F; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1984
Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling. Biochemical pharmacology, 1995, Jan-06, Volume: 49, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Cell Membrane; GTP Phosphohydrolases; Kinetics; Mice; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured	1995
Opioids and sexual behavior in the male rabbit: the role of central and peripheral opioid receptors. Journal of neural transmission. General section, 1994, Volume: 97, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Central Nervous System; Dose-Response Relationship, Drug; Ejaculation; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Narcotics; Oxymorphone; Peripheral Nervous System; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Sexual Behavior, Animal	1994
Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement; Pyrrolidines; Spinal Cord; Time Factors	1993
Discriminative stimulus effects of the 5HT1A agonist 8-OH-DPAT: attenuation by mu but not by kappa opioids. Psychopharmacology, 1995, Volume: 122, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Benzomorphans; Discrimination Learning; Drug Therapy, Combination; Fentanyl; Male; Morphine; Narcotics; Pyrimidines; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin Receptor Agonists	1995
Kappa opioid receptor agonists inhibit sigma-1 (sigma 1) receptor binding in guinea-pig brain, liver and spleen: autoradiographical evidence. Brain research, 1996, Jul-01, Volume: 725, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Brain; Guinea Pigs; Liver; Piperidines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, sigma; Spinal Cord; Spleen	1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. Life sciences, 1997, Volume: 60, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1997
Comparison of the effects of a series of kappa-opioid receptor agonists upon sodium channel function in rat brain miniprisms. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Brain; Disease Models, Animal; Inositol Phosphates; Naloxone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sodium Channels	1997
Coupling of the cloned rat kappa-opioid receptor to adenylyl cyclase is dependent on receptor expression. Neuroscience letters, 1997, Aug-29, Volume: 232, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzomorphans; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Etorphine; Gene Expression; Narcotic Antagonists; Phosphodiesterase Inhibitors; Pyrrolidines; Rats; Receptors, Opioid, kappa; Transfection	1997
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation	1997
Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes. Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Brain; Cell Membrane; Ethylketocyclazocine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Naltrexone; Narcotic Antagonists; Rana esculenta; Receptors, Opioid, kappa	1998
Comparative hypotensive actions of three nonpeptide kappa opioid agonists on hippocampus of SHRs and normotensive WKY rats. Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzomorphans; Dose-Response Relationship, Drug; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, kappa	1998
Lack of evidence of kappa2-selective activation of G-proteins: kappa opioid receptor stimulation of [35S] GTPgammaS binding in guinea pig brain. Biochemical pharmacology, 1998, Jul-01, Volume: 56, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Brain; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sulfur Radioisotopes	1998
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa	1999
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1999
Bremazocine reduces unrestricted free-choice ethanol self-administration in rats without affecting sucrose preference. Psychopharmacology, 1999, Volume: 142, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Alcoholism; Animals; Benzomorphans; Ethanol; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Reinforcement, Psychology; Self Administration; Sucrose	1999
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine. European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes	1999
Participation of central and peripheral kappa 1 and kappa 2 opioid receptors in arrhythmogenesis. Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzomorphans; Dynorphins; Male; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	1999
Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Central Nervous System; Cisterna Magna; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, kappa	1999
Opioid-dopamine interaction in planaria: a behavioral study. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1999, Volume: 124, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dopamine; Dopamine Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Motor Activity; Narcotic Antagonists; Planarians; Receptors, Opioid; Receptors, Opioid, kappa; Sulpiride	1999
Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine. Psychopharmacology, 2000, Volume: 150, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Central Nervous System Stimulants; Cocaine; Male; Motor Activity; Psychomotor Agitation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	2000
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors	2000
kappa-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line. Biochimica et biophysica acta, 2000, Dec-11, Volume: 1499, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenine; Apoptosis; Base Sequence; Benzomorphans; Cell Membrane; Colforsin; Cyclic AMP; Dideoxyadenosine; Drug Synergism; Epithelial Cells; Estrenes; Humans; Molecular Sequence Data; Pyrrolidinones; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases	2000
Sex and rat strain determine sensitivity to kappa opioid-induced antinociception. Psychopharmacology, 2002, Volume: 160, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Benzomorphans; Female; Male; Nalorphine; Narcotics; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sex Characteristics	2002
Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys. Brain research, 2003, Aug-22, Volume: 982, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Diuresis; Female; Injections, Intraventricular; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa	2003
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa	2010