bremazocine has been researched along with naltrexone in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (22.45) | 18.7374 |
| 1990's | 25 (51.02) | 18.2507 |
| 2000's | 11 (22.45) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, H; Hasebe, K; Izumimoto, N; Mochizuki, H; Momen, S; Nagase, H; Nakajima, R; Nemoto, T; Yamamoto, N | 1 |
| Craft, RM; Dykstra, LA | 2 |
| Horan, P; Porreca, F; Taylor, J; Yamamura, HI | 1 |
| Pinnock, RD | 1 |
| de Costa, BR; Horan, P; Porreca, F; Rice, KC | 1 |
| Klein, P; Nelson, WL; Olsen, LD; Simon, EJ; Yao, YH | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Bergman, J; Warren, PH | 1 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Leander, JD | 2 |
| Brocklehurst, C; Devia, C; Faust, WB; Moerschbaecher, JM | 1 |
| Bhargava, HN; Gulati, A | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Corbett, AD; Kosterlitz, HW | 1 |
| Calcagnetti, DJ; Cramer, CP; Fanselow, MS; Helmstetter, FJ | 1 |
| Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Nishiyama, N; Schwartz, JP; Taniwaki, T; Wilson, D | 1 |
| Boersma, CJ; Pool, CW; Van Heerikhuize, JJ; Van Leeuwen, FW | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; McNutt, RW; Mosberg, HI; Woods, JH | 1 |
| Cook, CD; Morgan, D; Negus, SS; Picker, MJ | 1 |
| Akil, H; Ardati, A; Civelli, O; Hoversten, MT; Meng, F; Monsma, FJ; Reinscheid, RK; Taylor, LP; Ueda, Y; Watson, SJ | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Fábián, G; Offermanns, S; Rottmann, M; Spicher, K; Szücs, M | 1 |
| Ingenito, AJ; Zhai, QZ | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Bian, JS; Wang, HX; Wong, TM; Wu, S; Yu, XC; Zhang, WM | 1 |
| De Vries, TJ; Homberg, JR; Mulder, AH; Nestby, P; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G | 1 |
| Holtzman, SG; Powell, KR | 1 |
| Butelman, ER; Johnson, MD; Ko, MC; Mosberg, HI; Willmont, KJ; Woods, JH | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L | 1 |
| Bolling, SF; Bowden, K; Claycomb, WC; Kenyon, E; Kovach, MA; Neilan, CL; Traynor, JR | 1 |
| Potter, DE; Russell, KR | 1 |
| Collins, SL; D'Addario, C; Gerdes, RM; Izenwasser, S | 1 |
| Cancela, LM; del Rosario Capriles, N | 1 |
| Flory, GS; Ko, MC; Lee, H; Willmont, KJ; Woods, JH | 1 |
| Folk, JE; Linsenmayer, DC; Negus, SS; Rice, KC; Stevenson, GW | 1 |
| Alves, DP; Amarante, LH; Duarte, ID | 1 |
| Ballard, ME; Harmon, AC; Holtzman, SG; White, DA | 1 |
| Bailey, A; Borsodi, A; Kieffer, BL; Kitchen, I; Matifas, A; Tóth, G; Yoo, JH | 1 |
| Dasher, WE; Klein, P; Nelson, WL | 1 |
| Klein, P; Nelson, WL | 1 |
49 other study(ies) available for bremazocine and naltrexone
| Article | Year |
|---|---|
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.
Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Cells, Cultured; Mice; Molecular Structure; Protein Binding; Receptors, Opioid, kappa; Structure-Activity Relationship; Substrate Specificity | 2011 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors | 1992 |
Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test.
Topics: Age Factors; Animals; Benzeneacetamides; Benzomorphans; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1992 |
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Cyclohexanes; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Topics: Animals; Benzomorphans; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Esters; Ethers; In Vitro Techniques; Ligands; Methacrylates; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1989 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Buprenorphine has potent kappa opioid receptor antagonist activity.
Topics: Animals; Benzomorphans; Buprenorphine; Diuresis; Drug Combinations; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in monkeys.
Topics: Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Cyclazocine; Dioxolanes; Dioxoles; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Female; Macaca fascicularis; Male; Naltrexone; Piperidines; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Cardiovascular responses to kappa opioid agonists in intact and adrenal demedullated rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzomorphans; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Tape Recording | 1988 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus.
Topics: Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Ethylketocyclazocine and bremazocine analgesia in neonatal rats.
Topics: Analgesia; Analgesics; Animals; Animals, Newborn; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Female; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats | 1988 |
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail | 1987 |
Effects of full and partial kappa agonists and mu agonists on urine output of normally hydrated rats.
Topics: Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Naltrexone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Benzomorphans; Brain; Enkephalin, Methionine; Etorphine; Gene Expression Regulation; Morphine; Naltrexone; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid | 1994 |
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa | 1994 |
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination Learning; Enkephalin, Leucine; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta | 1996 |
Moving from the orphanin FQ receptor to an opioid receptor using four point mutations.
Topics: Analgesics; Animals; Benzomorphans; Dynorphins; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Point Mutation; Rats; Receptors, Opioid | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Brain; Cell Membrane; Ethylketocyclazocine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Naltrexone; Narcotic Antagonists; Rana esculenta; Receptors, Opioid, kappa | 1998 |
Comparative hypotensive actions of three nonpeptide kappa opioid agonists on hippocampus of SHRs and normotensive WKY rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzomorphans; Dose-Response Relationship, Drug; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, kappa | 1998 |
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa | 1999 |
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Bremazocine reduces unrestricted free-choice ethanol self-administration in rats without affecting sucrose preference.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Alcoholism; Animals; Benzomorphans; Ethanol; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Reinforcement, Psychology; Self Administration; Sucrose | 1999 |
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes | 1999 |
Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Central Nervous System; Cisterna Magna; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, kappa | 1999 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
An immortalized myocyte cell line, HL-1, expresses a functional delta -opioid receptor.
Topics: Analgesics; Benzomorphans; Binding, Competitive; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Ligands; Myocardium; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 2000 |
Biphasic alterations of cAMP levels and inhibition of norepinephrine release in iris-ciliary body by bremazocine.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Benzomorphans; Ciliary Body; Cyclic AMP; Iris; Male; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Norepinephrine; Pertussis Toxin; Rabbits; Receptors, Opioid, kappa; Sympathetic Nervous System; Virulence Factors, Bordetella | 2001 |
Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Naltrexone; Nerve Net; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2002 |
Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Diuresis; Female; Injections, Intraventricular; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 2003 |
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 2003 |
Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.
Topics: 4-Aminopyridine; Analgesics; Animals; ATP-Binding Cassette Transporters; Benzomorphans; Charybdotoxin; Cyclic GMP; Dequalinium; Glyburide; Hyperalgesia; KATP Channels; Male; Naltrexone; Nitric Oxide; Peripheral Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction; Tetraethylammonium; Tolbutamide | 2004 |
Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumption.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzomorphans; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 2008 |
Knockout subtraction autoradiography: a novel ex vivo method to detect heteromers finds sparse KOP receptor/DOP receptor heterodimerization in the brain.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Gene Knockout Techniques; Male; Mice; Mice, Knockout; Naltrexone; Protein Multimerization; Protein Structure, Quaternary; Receptors, Opioid, delta; Receptors, Opioid, kappa; Subtraction Technique | 2014 |
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.
Topics: Acrylates; Animals; Binding Sites; Brain; Endorphins; Epoxy Compounds; Guinea Pigs; Lactones; Ligands; Naltrexone; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Thiocyanates | 1992 |
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium | 1992 |