bremazocine has been researched along with naloxone in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (54.32) | 18.7374 |
| 1990's | 27 (33.33) | 18.2507 |
| 2000's | 9 (11.11) | 29.6817 |
| 2010's | 1 (1.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pinnock, RD | 1 |
| Bianchi, G | 1 |
| Negus, SS; Picker, MJ; Powell, KR | 1 |
| Borsodi, A; Lajtha, A; Zawilska, J | 1 |
| Christensen, JD; Fjalland, B | 1 |
| Deviche, P; Lowry, CA; Moore, FL | 2 |
| Hammer, RP | 1 |
| Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Baraldi, M; Zanoli, P | 1 |
| Gyires, K | 1 |
| Ahmed, MS; Cavinato, AG; Maulik, D; Zhou, DH | 1 |
| Kobylyansky, AG; Nesterenko, PN; Pivovarov, AS; Yarygin, KN | 1 |
| Kobylyansky, AG | 1 |
| Makimura, M; Murakoshi, Y | 1 |
| Huidobro-Toro, JP; Roblero, J; Salas, SP; Ureta, H | 1 |
| Christensen, JD; Fjalland, B; Grell, S | 1 |
| Dykstra, LA; Picker, MJ | 1 |
| Bourgoin, S; Gallissot, MC; Gozlan, H; Hamon, M; Menard, F; Vergé, D | 1 |
| Deviche, P; Moore, FL | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA | 1 |
| Frey, HH | 1 |
| Millan, MJ; Morris, BJ | 1 |
| Herz, A; Millan, MJ; Morris, BJ | 1 |
| Barlow, JJ; Carroll, JA; Costello, GF; Main, BG; Shaw, JS | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Frances, B; Meunier, JC; Moisand, C | 1 |
| Ensinger, HA | 1 |
| Hayes, A; Kelly, A | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Shearman, GT; Zeugner, H | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR | 1 |
| Starr, MS | 1 |
| Conway, S; Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Shearman, GT; Stenfors, C | 1 |
| Leander, JD | 3 |
| Bakalkin, GIa; Pivovarov, AS; Romanenko, OK | 1 |
| Dykstra, LA; Heise, JW; Picker, M | 1 |
| Itzhak, Y; Simon, EJ | 1 |
| Bakalkin, GIa; Bespalova, ZhD; Iakovleva, TV; Korobov, KP; Vinogradov, VA | 1 |
| Huidobro-Toro, JP; Parada, S | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Fuller, RW; Leander, JD | 1 |
| Akil, H; Khachaturian, H; Lewis, ME; Watson, SJ | 1 |
| Akkerman, AM; Bakel, HC; Büscher, H; Hill, RC; Maurer, R; Petcher, TJ; Römer, D; Welle, HB | 1 |
| Kattau, RW; Leander, JD; Rathbun, RC | 1 |
| Code, RA; Tang, AH | 1 |
| Flórez, J; Pazos, A; Tristán, C | 1 |
| Gambino, MC; Petrillo, P; Tavani, A | 1 |
| Chaillet, P; Costentin, J; Marçais-Collado, H | 1 |
| Markó, M; Römer, D | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Agmo, A; Contreras, JL; Paredes, RG | 1 |
| Boersma, CJ; Pool, CW; Van Heerikhuize, JJ; Van Leeuwen, FW | 1 |
| Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW | 1 |
| Cook, CD; Morgan, D; Negus, SS; Picker, MJ | 1 |
| Kaputlu, I; Oğütman, C; Sadan, G | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Fowler, CJ; Tiger, G | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Gioannini, TL; Hiller, JM; Onoprishvili, I; Simon, EJ | 1 |
| Bakalkin, G; Derjabin, V; Hauser, KF; Nazarevskaja, G; Reznikov, K; Trunova, Y | 1 |
| Ananthanarayanan, VS; Zhorov, BS | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Bandari, P; Chaturvedi, K; Chinen, N; Christoffers, KH; Dondio, G; Howells, RD; Jiang, X; Raveglia, LF; Ronzoni, S | 1 |
| Chen, C; de Riel, JK; Huang, P; Javitch, JA; Li, J; Liu-Chen, LY; Xu, W | 1 |
| Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L | 1 |
| Cancela, LM; del Rosario Capriles, N | 1 |
| Ansonoff, M; Borsodi, A; Clarke, S; Czyzyk, T; Hill, R; Hsu, MS; Kitchen, I; Larsson, K; Nilsson, L; Nitsche, JF; Pintar, JE; Toth, G | 1 |
| Azzi, M; Bouvier, M; deLéan, A; Piñeyro, G; Schiller, PW | 1 |
| Dasher, WE; Klein, P; Nelson, WL | 1 |
| Klein, P; Nelson, WL | 1 |
| Klein, P; Nelson, WL; Olsen, LD; Simon, EJ; Yao, YH | 1 |
| Klein, P; Nelson, WL; Simon, EJ; Yao, YH | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
81 other study(ies) available for bremazocine and naloxone
| Article | Year |
|---|---|
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Benzomorphans; Dioxanes; Diuresis; Dose-Response Relationship, Drug; Idazoxan; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1991 |
Inactivation of kappa opioid receptors by N-ethylmaleimide.
Topics: Animals; Benzomorphans; Brain; Dihydromorphine; Ethylmaleimide; In Vitro Techniques; Naloxone; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Kappa-opioid receptor agonists differentially affect the release of neurohypophysial hormones.
Topics: Animals; Benzeneacetamides; Benzomorphans; Electric Stimulation; Female; In Vitro Techniques; Naloxone; Nerve Endings; Oxytocin; Pituitary Hormones, Posterior; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins | 1990 |
Effects of corticotropin-releasing factor (CRF) and opiates on amphibian locomotion.
Topics: Animals; Benzomorphans; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Locomotion; Male; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salamandridae | 1990 |
Mu-opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic.
Topics: Animals; Benzomorphans; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrus; Female; Male; Naloxone; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sex Characteristics | 1990 |
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Evidence that bremazocine prevents urine retention induced by intraspinal cord injection of colchicine in rats.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Colchicine; Eledoisin; Hypertrophy; Injections, Spinal; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Spinal Cord; Urinary Bladder; Urination | 1990 |
The effect of different opiates on acidified ethanol-induced gastric lesions in rats.
Topics: Animals; Benzomorphans; Enkephalin, Methionine; Ethanol; Morphine; Naloxone; Narcotics; Rats; Stomach Ulcer | 1990 |
Opioid binding properties of the purified kappa receptor from human placenta.
Topics: Benzomorphans; Binding, Competitive; Chromatography; Cyclazocine; Electrophoresis, Polyacrylamide Gel; Ethylketocyclazocine; Etorphine; Humans; Molecular Weight; Naloxone; Narcotics; Placenta; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Lateralization of opioid receptors in turtle visual cortex.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evoked Potentials, Visual; Functional Laterality; Morphine; Naloxone; Receptors, Opioid; Turtles; Visual Cortex | 1989 |
Opioids induce postural asymmetry in spinal rat: the side of the flexed limb depends upon the type of opioid agonist.
Topics: Animals; Benzomorphans; Decerebrate State; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Functional Laterality; Male; Muscles; Naloxone; Narcotics; Phenazocine; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1989 |
Kappa-opioid agonists do not inhibit adenylate cyclase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Levorphanol; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rana catesbeiana; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1989 |
Diuretic effect of bremazocine, a kappa-opioid with central and peripheral sites of action.
Topics: Animals; Benzomorphans; Blood Pressure; Brain; Diuresis; Female; Glomerular Filtration Rate; Kidney; Kidney Concentrating Ability; Male; Morphinans; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Water-Electrolyte Balance | 1989 |
Biphasic effect of a kappa-opioid receptor agonist on plasma oxytocin levels in rats.
Topics: Analgesics; Animals; Benzomorphans; Body Water; Brain Chemistry; Female; In Vitro Techniques; Male; Morphinans; Naloxone; Oxytocin; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Time Factors | 1989 |
Opiate control of spontaneous locomotor activity in a urodele amphibian.
Topics: Animals; Benzomorphans; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Morphinans; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Salamandridae | 1989 |
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord.
Topics: Animals; Animals, Newborn; Antiemetics; Autoradiography; Benzamides; Benzomorphans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Male; Naloxone; Nerve Tissue Proteins; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spinal Cord | 1989 |
Opioid kappa-receptor agonists suppress sexual behaviors in male rough-skinned newts (Taricha granulosa).
Topics: Analgesics; Animals; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Male; Morphinans; Morphine; Naloxone; Receptors, Opioid; Salamandridae; Sexual Behavior, Animal | 1987 |
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid | 1988 |
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature | 1987 |
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1988 |
Long-term blockade of mu-opioid receptors suggests a role in control of ingestive behaviour, body weight and core temperature in the rat.
Topics: Animals; Benzomorphans; Body Temperature Regulation; Body Weight; Circadian Rhythm; Drinking Behavior; Feeding Behavior; Fentanyl; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil | 1988 |
Antagonist-induced opioid receptor up-regulation. II. Regionally specific modulation of mu, delta and kappa binding sites in rat brain revealed by quantitative autoradiography.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Nigra | 1988 |
A novel series of potent and selective agonists at the opioid kappa-receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Profile of activity of kappa receptor agonists in the rabbit vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
The kappa opioid receptor and food intake.
Topics: Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Diprenorphine; Eating; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Time Factors | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Multiple opiate receptors may be involved in suppressing gamma-aminobutyrate release in substantia nigra.
Topics: Aminooxyacetic Acid; Animals; Benzomorphans; Dopamine; Enkephalin, Methionine; Female; gamma-Aminobutyric Acid; Male; Naloxone; Nialamide; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Secretory Rate; Substantia Nigra | 1985 |
Opioid kappa receptors and the secretion of prolactin (PRL) and growth hormone (GH) in the rat. I. Effects of opioid kappa receptor agonists bremazocine and U-50,488 on secretion of PRL and GH: comparison with morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Growth Hormone; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1986 |
Bremazocine-induced backwards walking behavior in rats is mediated via opioid kappa receptors.
Topics: Animals; Benzomorphans; Brain; Hallucinogens; Locomotion; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Delineation of mu-antagonist, partial kappa agonist and non-opioid agonist activity of cyclazocine using urinary output of rats.
Topics: Animals; Benzomorphans; Cyclazocine; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 1987 |
[Effect of the opiate antagonist naloxone on the electrical activity of identified neurons in the edible snail].
Topics: Animals; Benzomorphans; beta-Endorphin; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Helix, Snails; Membrane Potentials; Morphine; Naloxone; Neurons; Receptors, Opioid | 1987 |
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule | 1987 |
A novel phencyclidine analog interacts selectively with mu opioid receptors.
Topics: Analgesia; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Dihydromorphine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vas Deferens | 1984 |
[Binding sites of opiates and endogenous opioids in the oocytes of the toad Bufo viridis].
Topics: Animals; Benzomorphans; Binding Sites; Bufonidae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Kinetics; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Oocytes; Rabbits; Receptors, Opioid; Vas Deferens | 1984 |
Kappa opioid agonists and antagonists: effects on drinking and urinary output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins | 1984 |
Kappa-opiates and urination: pharmacological evidence for an endogenous role of the kappa-opiate receptor in fluid and electrolyte balance.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Female; Injections, Intraperitoneal; Morphinans; Morphine; Naloxone; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium; Water-Electrolyte Balance | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Further study of kappa opioids on increased urination.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Morphinans; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1983 |
Elevation of serum corticosterone in rats by bremazocine, a kappa-opioid agonist.
Topics: Animals; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain.
Topics: Animals; Benzomorphans; Brain; Brain Mapping; Dynorphins; Endorphins; Enkephalins; Macaca mulatta; Naloxone; Pro-Opiomelanocortin; Radioligand Assay; Receptors, Opioid; Synaptic Transmission | 1984 |
Bremazocine: a potent, long-acting opiate kappa-agonist.
Topics: Analgesia; Animals; Benzomorphans; Brain; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; Ileum; Macaca mulatta; Male; Mice; Morphinans; Morphine; Naloxone; Pentazocine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1980 |
Effects of mu- and kappa-opioid receptor agonists on urinary output in mice.
Topics: Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Stimulation, Chemical; Urination | 1983 |
Discriminative stimulus properties of nalorphine in the rhesus monkeys.
Topics: Animals; Benzodiazepines; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Nalorphine; Naloxone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
A comparative study of the respiratory depressant and analgesic effects of bremazocine, a kappa-agonist.
Topics: Analgesia; Analgesics; Animals; Benzomorphans; Drug Antagonism; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Respiration | 1983 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation.
Topics: Animals; Benzomorphans; Catatonia; Cyclazocine; Enkephalins; Ethylketocyclazocine; Fentanyl; Humans; Immobilization; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics | 1983 |
Inhibitory effect of a new opioid agonist on reproductive endocrine activity in rats of both sexes.
Topics: Animals; Benzomorphans; Castration; Cells, Cultured; Female; In Vitro Techniques; Luteinizing Hormone; Male; Morphinans; Morphine; Naloxone; Ovulation; Pituitary Gland; Rats; Rats, Inbred Strains; Reproduction; Testis; Time Factors | 1983 |
Acute withdrawal after bremazocine and the interaction between mu- and kappa-opioid receptors in isolated gut tissues.
Topics: Animals; Benzomorphans; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Morphine; Muscle Contraction; Naloxone; Rabbits; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1995 |
Opioids and sexual behavior in the male rabbit: the role of central and peripheral opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Central Nervous System; Dose-Response Relationship, Drug; Ejaculation; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Narcotics; Oxymorphone; Peripheral Nervous System; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Sexual Behavior, Animal | 1994 |
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa | 1994 |
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection | 1995 |
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta | 1996 |
Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits.
Topics: Animals; Baroreflex; Benzomorphans; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Comparison of the effects of a series of kappa-opioid receptor agonists upon sodium channel function in rat brain miniprisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Brain; Disease Models, Animal; Inositol Phosphates; Naloxone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sodium Channels | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Inactivation of the purified bovine mu opioid receptor by sulfhydryl reagents.
Topics: Animals; Benzomorphans; Cattle; Cell Membrane; Corpus Striatum; Cysteine; Dithionitrobenzoic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Naloxone; Radioligand Assay; Receptors, Opioid, mu; Sulfhydryl Reagents; Tritium | 1999 |
Opioids modulate cell division in the germinal zone of the late embryonic neocortex.
Topics: Animals; Benzomorphans; Cell Division; Cerebral Ventricles; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Mice; Mice, Inbred CBA; Mitotic Index; Naloxone; Narcotic Antagonists; Narcotics; Neocortex; Pregnancy; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Homology models of mu-opioid receptor with organic and inorganic cations at conserved aspartates in the second and third transmembrane domains.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Aspartic Acid; Benzomorphans; Binding Sites; Cations; Cattle; Computer Simulation; Conserved Sequence; Fentanyl; Humans; Ligands; Metals; Models, Molecular; Molecular Sequence Data; Morphine; Naloxone; Narcotic Antagonists; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Opioid, mu; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Pharmacological profiles of selective non-peptidic delta opioid receptor ligands.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Benzomorphans; Binding, Competitive; Cells, Cultured; Cloning, Molecular; Down-Regulation; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Kidney; Ligands; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morphine; Mutagenesis, Site-Directed; Naloxone; Narcotic Antagonists; Quinolines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 2000 |
The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.
Topics: Amino Acid Sequence; Animals; Benzomorphans; Binding Sites; Cell Line; Conserved Sequence; Cysteine; Diprenorphine; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Glutamic Acid; Humans; Indicators and Reagents; Mesylates; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Narcotic Antagonists; Protein Structure, Secondary; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serine; Time Factors; Tritium | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2002 |
Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.
Topics: Animals; Autoradiography; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Mice; Mice, Knockout; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Spinal Cord; Vasodilator Agents | 2002 |
Reciprocal regulation of agonist and inverse agonist signaling efficacy upon short-term treatment of the human delta-opioid receptor with an inverse agonist.
Topics: Benzomorphans; Binding Sites; Cell Line; Cell Membrane; Cyclic AMP; Cycloheximide; DNA, Complementary; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Naloxone; Phosphorylation; Receptors, Opioid, delta; Recombinant Proteins; Transfection | 2005 |
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.
Topics: Acrylates; Animals; Binding Sites; Brain; Endorphins; Epoxy Compounds; Guinea Pigs; Lactones; Ligands; Naltrexone; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Thiocyanates | 1992 |
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium | 1992 |
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Topics: Animals; Benzomorphans; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Esters; Ethers; In Vitro Techniques; Ligands; Methacrylates; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1990 |
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates | 1990 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |