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bradykinin, leu(8)-des-arg(9)- and indomethacin

bradykinin, leu(8)-des-arg(9)- has been researched along with indomethacin in 13 studies

Compound Research Comparison

Studies
(bradykinin, leu(8)-des-arg(9)-)
Trials
(bradykinin, leu(8)-des-arg(9)-)
Recent Studies (post-2010)
(bradykinin, leu(8)-des-arg(9)-)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
1020729,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomybradykinin, leu(8)-des-arg(9)- (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's9 (69.23)18.2507
2000's3 (23.08)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Illiano, S; Mombouli, JV; Vanhoutte, PM1
Churchill, L; Ward, PE1
Advenier, C; Hirsch, A; Martin, CA; Molimard, M; Naline, E1
Andreeva, L; Rang, HP1
Davis, AJ; Perkins, MN1
Berezin, M; Prior, T; Rangachari, PK1
Ferreira, SH; Tonussi, CR1
Andersson, RG; Persson, K1
Calixto, JB; de Campos, RO; Henriques, MG1
Cunha, FQ; Cunha, JM; Ferreira, SH; Lorenzetti, BB; Poole, S1
Chichorro, JG; Lorenzetti, BB; Zampronio, AR1
Bergren, DR1
Cunha, FQ; Cunha, TM; Ferreira, SH; Fukada, SY; Guerrero, AT; Parada, CA; Poole, S; Santodomingo-Garzón, T; Verri, WA1

Other Studies

13 other study(ies) available for bradykinin, leu(8)-des-arg(9)- and indomethacin

ArticleYear
Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries.
    Agents and actions. Supplements, 1992, Volume: 38 ( Pt 3)

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Bradykinin; Carotid Arteries; Dogs; Endothelium, Vascular; In Vitro Techniques; Indoles; Indomethacin; Kininogens; Kinins; Muscle, Smooth, Vascular; Nitroarginine; Nitroprusside; Vasodilation

1992
Conversion of B1 kinin receptor-mediated vascular relaxation to contraction.
    Hypertension (Dallas, Tex. : 1979), 1987, Volume: 9, Issue:6 Pt 2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Dose-Response Relationship, Drug; Indomethacin; Kallidin; Male; Pyrazoles; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Vasoconstriction; Vasodilation

1987
Contractile effects of bradykinin on the isolated human small bronchus.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

    Topics: Acetylcholine; Aged; Atropine; Benzamides; Biphenyl Compounds; Bradykinin; Bronchi; Bronchoconstriction; Capsaicin; Humans; In Vitro Techniques; Indomethacin; Middle Aged; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Bradykinin; Ruthenium Red; Tetrodotoxin

1994
Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Colforsin; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Molecular Sequence Data; Prostaglandins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat.
    British journal of pharmacology, 1994, Volume: 113, Issue:1

    Topics: Animals; Bradykinin; Cytokines; Female; Hyperalgesia; Indomethacin; Injections, Intra-Articular; Interleukins; Knee Joint; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin

1994
Effects of bradykinin on the canine proximal colon.
    Regulatory peptides, 1993, Jul-23, Volume: 46, Issue:3

    Topics: Amino Acid Sequence; Animals; Bradykinin; Colon; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Epithelium; Female; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Molecular Sequence Data; Tetrodotoxin

1993
Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception.
    European journal of pharmacology, 1997, May-12, Volume: 326, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Hindlimb; Hyperalgesia; Indomethacin; Joints; Male; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Receptors, Bradykinin

1997
Biphasic response to bradykinin in isolated porcine iliac arteries is mediated by bradykinin B1 and B2 receptors.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:2

    Topics: 3-Mercaptopropionic Acid; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cilazapril; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enalaprilat; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Protease Inhibitors; Protein Synthesis Inhibitors; Receptors, Bradykinin; Swine; Vasoconstriction; Vasodilation

1998
Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice.
    Neuropeptides, 1998, Volume: 32, Issue:5

    Topics: Animals; Bradykinin; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Edema; Formaldehyde; Hindlimb; Indomethacin; Kallidin; Male; Mice; Mycobacterium bovis; Pain; Pain Measurement; Pyrazoles; Receptor, Bradykinin B1; Receptors, Bradykinin

1998
Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia.
    British journal of pharmacology, 1999, Volume: 126, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Hyperalgesia; Indomethacin; Inflammation; Interleukin-8; Kallidin; Lipopolysaccharides; Male; Mice; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Sheep; Time Factors; Tumor Necrosis Factor-alpha

1999
Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.
    British journal of pharmacology, 2004, Volume: 141, Issue:7

    Topics: Animals; Arachidonic Acids; Atenolol; Behavior, Animal; Biogenic Amines; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Captopril; Celecoxib; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Guanethidine; Hindlimb; Indomethacin; Injections, Subcutaneous; Interleukin-6; Interleukin-8; Lip; Male; Meloxicam; Nociceptors; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha; Tyramine

2004
Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:6

    Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Asthma; Blood Pressure; Bradykinin; Capsaicin; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Guinea Pigs; Heart Rate; Indomethacin; Lung; Nerve Fibers, Unmyelinated; Prostaglandins; Respiratory Hypersensitivity; Substance P

2006
TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Animals; Antibodies; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Bradykinin Receptor Antagonists; Carrageenan; Dose-Response Relationship, Drug; Guanethidine; Hyperalgesia; Indomethacin; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandins; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha

2007