bradykinin, leu(8)-des-arg(9)- has been researched along with bradykinin in 97 studies
Studies (bradykinin, leu(8)-des-arg(9)-) | Trials (bradykinin, leu(8)-des-arg(9)-) | Recent Studies (post-2010) (bradykinin, leu(8)-des-arg(9)-) | Studies (bradykinin) | Trials (bradykinin) | Recent Studies (post-2010) (bradykinin) |
---|---|---|---|---|---|
102 | 0 | 7 | 14,195 | 355 | 1,520 |
Protein | Taxonomy | bradykinin, leu(8)-des-arg(9)- (IC50) | bradykinin (IC50) |
---|---|---|---|
B2 bradykinin receptor | Homo sapiens (human) | 0.0018 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (6.19) | 18.7374 |
1990's | 58 (59.79) | 18.2507 |
2000's | 22 (22.68) | 29.6817 |
2010's | 11 (11.34) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Escher, E; Guillemette, G; Laczkó, E; Regoli, D | 1 |
Borkowski, JA; Derrick, AW; Hess, JF; MacNeil, T | 1 |
Austin, CE; Bathon, JM; Chakravarty, S; Faussner, A; Kyle, DJ; Proud, D; Robinson, HE | 1 |
Aramori, I; Asano, M; Iwami, M; Kojo, H; Morikawa, N; Nakamura, K; Notsu, Y; O'Donnell, N; Zenkoh, J | 1 |
Arbuckle, J; Bevan, SJ; Burgess, GM; Davis, C; Docherty, RJ; Jones, C; McIntyre, P; Phillips, E; Webb, M; Yaqoob, M | 1 |
Amblard, M; Bedos, P; Daffix, I; Dodey, P; Luccarini, JM; Martinez, J; Olivier, C; Paquet, JL; Pruneau, D | 1 |
Alvarez, AL; Delorenzi, A; Finkielman, S; Nahmod, VE; Pirola, CJ; Santajuliana, D | 1 |
Campbell, JN; Khan, AA; Manning, DC; Meyer, RA; Raja, SN | 1 |
Gobeil, F; Regoli, D; Rhaleb, NE | 1 |
Illiano, S; Mombouli, JV; Vanhoutte, PM | 1 |
Blöchl, A; Brenner, P; Dominiak, P; Simon, M | 1 |
Harik, SI; Homayoun, P | 1 |
Staszewska-Woolley, J; Woodman, OL | 1 |
Mantione, CR; Rodriguez, R | 1 |
Okabe, E; Sugihara, M; Todoki, K | 1 |
Northover, AM | 1 |
Barnes, PJ; Ichinose, M | 1 |
Kumazawa, T; Minagawa, M; Mizumura, K; Tsujii, Y | 1 |
McFadden, RG; Vickers, KE | 1 |
Churchill, L; Ward, PE | 1 |
Bettaney, J; Dray, A; Forster, P; Perkins, MN | 1 |
Marceau, F; Tremblay, B | 1 |
Couture, R; Laneuville, O | 1 |
Advenier, C; Hirsch, A; Martin, CA; Molimard, M; Naline, E | 1 |
Chulak, C; Couture, R; Foucart, S | 1 |
Andreeva, L; Rang, HP | 1 |
Fan, TP; Hu, DE | 1 |
Fu, T; Gu, ZL; Xu, YH | 1 |
Butt, SK; Dawson, LG; Hall, JM | 1 |
Oh-ishi, S; Tokumasu, T; Ueno, A | 1 |
Davis, AJ; Perkins, MN | 1 |
Butt, SK; Field, JL; Hall, JM; Morton, IK | 1 |
Griesbacher, T; Legat, FJ; Lembeck, F | 1 |
Hsia, HC; Hsieh, JT; Luo, SF; Ong, R; Yang, CM | 1 |
Berezin, M; Prior, T; Rangachari, PK | 1 |
Campbell, E; Dray, A; Perkins, MN | 1 |
Brown, M; McIntyre, P; Phillips, E; Skidmore, E; Webb, M | 1 |
Cocks, TM; Drummond, GR | 1 |
Ahluwalia, A; Perretti, M | 1 |
Kato, M; Kobayashi, I; Saito, Y; Tatemoto, K | 1 |
Lecci, A; Maggi, CA; Meini, S | 1 |
Burkard, MR; Cuadrado, DK; Greer, RA; Selig, WM; Whalley, ET; Zuzack, JS | 1 |
Catanzaro, O; Cueva, F; Frontera, M; Navarro, M; Zuccollo, A | 1 |
Roach, TJ; Sufka, KJ | 1 |
Catanzaro, O; Navarro, M; Zuccollo, A | 1 |
Dedio, J; Schölkens, BA; Wiemer, G; Wirth, K; Wohlfart, P | 1 |
Antúnez, P; Pérez, H; Rothlin, RP; Sardi, SP | 1 |
Ferreira, SH; Tonussi, CR | 2 |
Borkowski, JA; Boyce, S; Carlson, EJ; Hess, JF; Hill, RG; Rupniak, NM; Webb, JK; Williams, AR | 1 |
Cuthbert, AW; Teather, S | 2 |
Buchinger, P; Chondromatidou, A; Hermann, A; Miska, K; Rehbock, J | 1 |
Arakawa, M; Fujimura, A; Ohmori, M; Sakamoto, K; Sugimoto, K | 1 |
Knox, AJ; Pang, L | 1 |
Gao, XP; Oda, D; Pakhlevaniants, S; Rubinstein, I | 1 |
Andersson, RG; Persson, K | 1 |
Abbas, F; Clayton, JK; Marshall, KM; Senior, J | 1 |
Da Silva, A; Gies, JP; Lach, E; Landry, Y; Scherrer, D; Schmidlin, F | 1 |
Habib, S; Jaggar, SI; Rice, AS | 1 |
Cheronis, JC; Fritz, H; Lehner, M; Schorr, M; Siebeck, M; Spannagl, E; Whalley, ET | 1 |
Calixto, JB; de Campos, RO; Henriques, MG | 1 |
Charland, S; Filteau, C; Gobeil, F; Neugebauer, W; Perron, SI; Regoli, D | 1 |
Cunha, FQ; Cunha, JM; Ferreira, SH; Lorenzetti, BB; Poole, S | 1 |
Bateson, EA; Olley, PM; Schulz, R | 1 |
Al-Rashed, S; Brain, SD; Cao, T; Gerard, N; Hoult, JR; Pintér, E | 1 |
Levy, D; Zochodne, DW | 1 |
Bentley, KR; Jarrott, B | 1 |
Bader, M; Bonaria Salis, M; Cayla, C; Emanueli, C; Gaspa, L; Isner, JM; Kirchmair, R; Madeddu, P; Pesquero, JB; Pinna, A; Pintus, G; Regoli, D; Stacca, T | 1 |
Calixto, JB; Cordeiro, RS; e Silva, PM; Lavich, TR; Martins, MA | 1 |
Daaka, Y; Guo, R; Leeb-Lundberg, LM; Madden, JF; Taub, JS | 1 |
Kohno, S; Mizutani, N; Nabe, T; Sugahara, S; Takenaka, H | 1 |
Caruso-Neves, C; Corrêa da Costa, VM; Gomes, VO; Lopes, AG; Lóss, FF; Malaquias, AT | 1 |
Asada, A; Maeda, K; Nakamura, M; Watanabe, T; Yasunari, K; Yoshikawa, J | 1 |
Chichorro, JG; Lorenzetti, BB; Zampronio, AR | 1 |
Arunkumar, R; Brennan, TJ; Leonard, PA | 1 |
Araújo, RC; Bader, M; Beirith, A; Calixto, JB; Ferreira, J; Mori, MA; Pesquero, JB | 1 |
Cidlowski, JA; Rhen, T | 1 |
Farias, NC; Feres, T; Paiva, AC; Paiva, TB | 1 |
Ghilardi, JR; Halvorson, KG; Kubota, K; Lindsay, TH; Mantyh, PW; Sevcik, MA | 1 |
Bergren, DR | 1 |
Calixto, JB; Ferreira, J; Kassuya, CA; Rae, GA; Werner, MF; Zampronio, AR | 1 |
Cunha, FQ; Cunha, TM; Ferreira, SH; Fukada, SY; Guerrero, AT; Parada, CA; Poole, S; Santodomingo-Garzón, T; Verri, WA | 1 |
Bader, M; Cheung, G; Färber, K; Ifuku, M; Ishikawa, E; Iwamoto, T; Kettenmann, H; Kita, S; Komuro, I; Merrino, VF; Miyamoto, T; Noda, M; Nolte, C; Okuno, Y; Ooboshi, H; Wada, K; Wang, B; Yamakawa, Y | 1 |
Aoki, M; Inoue, N; Kobayashi, K; Kondo, T; Li, P; Murohara, T; Numaguchi, Y; Okumura, K | 1 |
Calixto, JB; Campos, MM; Duarte, FS; Medeiros, R; Pandolfo, P; Passos, GF; Pesquero, JB; Prediger, RD; Takahashi, RN | 1 |
Calixto, JB; Chichorro, JG; Luiz, AP; Rae, GA; Schroeder, SD; Zampronio, AR | 1 |
Akira, A; Andoh, T; Kuraishi, Y; Saiki, I | 1 |
Calixto, JB; Costa, R; Juliano, L; Manjavachi, MN; Marotta, DM; Motta, EM; Pesquero, JB; Torres, HA | 1 |
Chen, Q; Lai, J; Ossipov, MH; Porreca, F; Vardanyan, M; Vera-Portocarrero, LP | 1 |
Araújo, RC; Braga, TT; Buscariollo, BN; Câmara, NO; Corrêa-Costa, M; Filho, AP; Keller, AC; Malheiros, DM; Maquigussa, E; Moura, IC; Oliveira, CD; Pereira, RL; Reis, VO; Semedo, P; Soares, MF | 1 |
Bento, AF; Calixto, JB; Costa, R; Dutra, RC; Malinsky, FR; Manjavachi, MN; Motta, EM; Pesquero, JB | 1 |
Bento, AF; Bouzon, ZL; Calixto, JB; Claudino, RF; Dutra, RC; Marcon, R; Morais, RL; Pesquero, JB; Schmidt, EC; Sordi, R | 1 |
Bobinski, F; Brum, JS; de Barros, CS; de Campos Velho Gewehr, C; de Oliveira, CV; Della-Pace, ID; dos Santos, AR; Ferreira, AP; Ferreira, J; Fighera, MR; Furian, AF; Mota, BC; Oliveira, MS; Oliveira, SM; Rodrigues, FS; Royes, LF | 1 |
Calixto, JB; Chichorro, JG; Luiz, AP; Rae, GA; Schroeder, SD | 1 |
Bicca, MA; Bitencourt, RM; Calixto, JB; de Mello, N; Guerra de Souza, AC; Medeiros, R; Pamplona, FA; Passos, GF; Prediger, RD; Takahashi, RN | 1 |
Dąbrowska-Bouta, B; Podsiadło, K; Strużyńska, L; Sulkowski, G | 1 |
97 other study(ies) available for bradykinin, leu(8)-des-arg(9)- and bradykinin
Article | Year |
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Biological activities of photoaffinity labeling analogues of kinins and their irreversible effects on kinin receptors.
Topics: Affinity Labels; Animals; Binding, Competitive; In Vitro Techniques; Kinins; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Bradykinin; Receptors, Cell Surface; Structure-Activity Relationship | 1981 |
The agonist selectivity of a mouse B1 bradykinin receptor differs from human and rabbit B1 receptors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bradykinin; Cattle; Cloning, Molecular; COS Cells; DNA Primers; DNA, Complementary; Humans; Kallidin; Mice; Molecular Sequence Data; Rabbits; Receptor, Bradykinin B1; Receptors, Bradykinin; Sequence Homology, Amino Acid; Species Specificity; Transfection | 1996 |
Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.
Topics: Animals; Binding, Competitive; Biological Transport; Bradykinin; Bradykinin Receptor Antagonists; CHO Cells; Cricetinae; GTP-Binding Proteins; Humans; Inositol Phosphates; Kallidin; Ligands; Oligopeptides; Precipitin Tests; Protein Binding; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Recombinant Proteins; Signal Transduction; Type C Phospholipases | 1997 |
Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657.
Topics: Animals; Aorta; Bradykinin Receptor Antagonists; Cricetinae; Dose-Response Relationship, Drug; Humans; Kidney; Pyridines; Quinolines | 1997 |
Molecular characterisation of cloned bradykinin B1 receptors from rat and human.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Cell Line; Cloning, Molecular; COS Cells; DNA, Complementary; Female; Gene Expression; Genes; Humans; Kallidin; Molecular Sequence Data; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptors, Bradykinin; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tissue Distribution; Tritium | 1999 |
Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Structure-Activity Relationship; Transfection; Umbilical Veins | 2000 |
Central bradykininergic system in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Bradykinin; Brain; Dose-Response Relationship, Drug; Heart Rate; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Bradykinin; Receptors, Neurotransmitter | 1992 |
The effects of bradykinin and sequence-related analogs on the response properties of cutaneous nociceptors in monkeys.
Topics: Afferent Pathways; Analgesics; Animals; Bradykinin; Evoked Potentials, Somatosensory; Macaca fascicularis; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Sensory Thresholds; Skin; Synaptic Transmission | 1992 |
Non-selectivity of new bradykinin antagonists for B1 receptors.
Topics: Amino Acid Sequence; Animals; Aorta; Binding, Competitive; Bradykinin; Guinea Pigs; Ileum; In Vitro Techniques; Jugular Veins; Kinetics; Molecular Sequence Data; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetrahydroisoquinolines | 1992 |
Local production of kinins contributes to the endothelium dependent relaxations evoked by converting enzyme inhibitors in isolated arteries.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Bradykinin; Carotid Arteries; Dogs; Endothelium, Vascular; In Vitro Techniques; Indoles; Indomethacin; Kininogens; Kinins; Muscle, Smooth, Vascular; Nitroarginine; Nitroprusside; Vasodilation | 1992 |
Modulation of presynaptic sympathetic activity by kinins and related compounds: influence of converting enzyme inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Electric Stimulation; Epinephrine; Male; Norepinephrine; Ramipril; Rats; Rats, Inbred BN; Rats, Inbred SHR; Sympathetic Nervous System; Synapses | 1992 |
Bradykinin receptors of cerebral microvessels stimulate phosphoinositide turnover.
Topics: Animals; Binding, Competitive; Bradykinin; Brain; Hydrolysis; Inositol Phosphates; Male; Microcirculation; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Bradykinin; Receptors, Neurotransmitter; Swine | 1991 |
Kinin receptors mediating the effects of bradykinin on the coronary circulation in anaesthetized greyhounds.
Topics: Animals; Blood Pressure; Bradykinin; Coronary Circulation; Coronary Vessels; Dogs; Fluoroacetates; Heart Rate; Receptors, Bradykinin; Receptors, Neurotransmitter; Reflex; Vagus Nerve; Vascular Resistance | 1991 |
A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.
Topics: Animals; Bradykinin; Capsaicin; Ear, External; Edema; Inflammation; Male; Mice; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P | 1990 |
[The contractile response of isolated lingual arteries from rabbits treated with bacterial lipopolysaccharide via the stimulation of B1-receptors for kinins].
Topics: Animals; Arteries; Bradykinin; Cycloheximide; Dactinomycin; Endotoxins; Escherichia coli; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Tongue | 1991 |
Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro.
Topics: Aminoquinolines; Animals; Bradykinin; Calcimycin; Calcium; Cimetidine; Endothelium, Vascular; Guinea Pigs; Histamine; Histamine Antagonists; Isoproterenol; Platelet Activating Factor; Pyrilamine; Vena Cava, Inferior | 1990 |
Bradykinin-induced airway microvascular leakage and bronchoconstriction are mediated via a bradykinin B2 receptor.
Topics: Animals; Bradykinin; Bronchoconstriction; Capillary Permeability; Guinea Pigs; Male; Receptors, Bradykinin; Receptors, Neurotransmitter; Respiratory System | 1990 |
The effects of bradykinin agonists and antagonists on visceral polymodal receptor activities.
Topics: Animals; Bradykinin; Dogs; Epididymis; In Vitro Techniques; Male; Neurons, Afferent; Testis | 1990 |
Bradykinin augments the in vitro migration of nonsensitized lymphocytes.
Topics: Angiotensin II; Animals; Bradykinin; Chemotaxis, Leukocyte; Concanavalin A; Humans; Kallidin; Lymphocytes; Rats; Rats, Inbred Strains; Receptors, Bradykinin; Receptors, Neurotransmitter; Spleen | 1989 |
Conversion of B1 kinin receptor-mediated vascular relaxation to contraction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Dose-Response Relationship, Drug; Indomethacin; Kallidin; Male; Pyrazoles; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Vasoconstriction; Vasodilation | 1987 |
Activation of a bradykinin receptor in peripheral nerve and spinal cord in the neonatal rat in vitro.
Topics: Animals; Animals, Newborn; Bradykinin; In Vitro Techniques; Membrane Potentials; Peripheral Nerves; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Mitogenic effect of bradykinin and of des-Arg9-bradykinin on cultured fibroblasts.
Topics: Animals; Bradykinin; Dinoprostone; Fibroblasts; Humans; Mitosis; Prostaglandins E; Rabbits; Thymidine | 1986 |
Bradykinin analogue blocks bradykinin-induced inhibition of a spinal nociceptive reflex in the rat.
Topics: Animals; Bradykinin; Male; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Reflex; Spinal Cord | 1987 |
Contractile effects of bradykinin on the isolated human small bronchus.
Topics: Acetylcholine; Aged; Atropine; Benzamides; Biphenyl Compounds; Bradykinin; Bronchi; Bronchoconstriction; Capsaicin; Humans; In Vitro Techniques; Indomethacin; Middle Aged; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Bradykinin; Ruthenium Red; Tetrodotoxin | 1994 |
Modulatory effect of bradykinin on the release of noradrenaline from rat isolated atria.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Angiotensin II; Animals; Bradykinin; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fenoterol; Heart Atria; Indoles; Male; Maleimides; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar | 1995 |
Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Colforsin; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Molecular Sequence Data; Prostaglandins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
[Leu8]des-Arg9-bradykinin inhibits the angiogenic effect of bradykinin and interleukin-1 in rats.
Topics: Animals; Bradykinin; Hemoglobins; Humans; Inflammation; Interleukin-1; Male; Neovascularization, Pathologic; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurotransmitter; Recombinant Proteins | 1993 |
Modulation of bradykinin-induced intracellular Ca2+ oscillations in v-Ki-ras-transformed fibroblasts.
Topics: 3T3 Cells; Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium Channels; Calcium-Transporting ATPases; Genes, ras; Mice; Terpenes; Thapsigargin | 1994 |
Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis.
Topics: Amino Acid Sequence; Animals; Bradykinin; Hydrolysis; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Rabbits; Receptors, Bradykinin; Urinary Bladder | 1995 |
A hypotensive response induced by des-Arg9-bradykinin in young brown/Norway rats pretreated with endotoxin.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Drug Interactions; Escherichia coli; Hypotension; Lipopolysaccharides; Male; Molecular Sequence Data; Rats; Rats, Inbred BN; Specific Pathogen-Free Organisms | 1995 |
The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat.
Topics: Animals; Bradykinin; Cytokines; Female; Hyperalgesia; Indomethacin; Injections, Intra-Articular; Interleukins; Knee Joint; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin | 1994 |
Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci.
Topics: Amino Acid Sequence; Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium; Cecum; Culture Media; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphatidylinositols; Potassium; Receptors, Bradykinin; Sodium | 1994 |
Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum.
Topics: Animals; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Edema; Female; Foot; Histamine H1 Antagonists; Histamine H2 Antagonists; Hypnotics and Sedatives; Microbial Collagenase; Motor Activity; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 1994 |
Bradykinin-stimulated calcium mobilization in cultured canine tracheal smooth muscle cells.
Topics: Animals; Bradykinin; Calcium; Carbachol; Cells, Cultured; Diltiazem; Dogs; Dose-Response Relationship, Drug; Egtazic Acid; Female; Fura-2; Kallidin; Male; Muscle, Smooth; Trachea; Verapamil | 1994 |
Effects of bradykinin on the canine proximal colon.
Topics: Amino Acid Sequence; Animals; Bradykinin; Colon; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Epithelium; Female; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Molecular Sequence Data; Tetrodotoxin | 1993 |
Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat.
Topics: Analgesics; Animals; Bradykinin; Disease Models, Animal; Female; Freund's Adjuvant; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Bradykinin; Receptors, Neurotransmitter; Ultraviolet Rays | 1993 |
Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bradykinin; Cell Line; Cloning, Molecular; DNA; Humans; Mice; Molecular Sequence Data; Oocytes; Polymerase Chain Reaction; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Transfection; Tumor Cells, Cultured; Xenopus laevis | 1993 |
Endothelium-dependent relaxations mediated by inducible B1 and constitutive B2 kinin receptors in the bovine isolated coronary artery.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Bradykinin; Bradykinin Receptor Antagonists; Cattle; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Protein Synthesis Inhibitors | 1995 |
Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Chemotaxis, Leukocyte; Interleukin-1; Male; Mice; Neutrophil Activation; Neutrophils; Receptors, Bradykinin | 1996 |
Effects of bradykinin on the intracellular calcium concentration of pancreatic acinar AR42J cells.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Intracellular Fluid; Neomycin; Pancreas; Rats | 1996 |
The longitudinal muscle of rat ileum as a sensitive monoreceptor assay for bradykinin B1 receptors.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Bradykinin; Guinea Pigs; Ileum; Male; Muscle, Smooth; Rats; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Tetrahydroisoquinolines; Urinary Bladder | 1996 |
Inducible bradykinin B1 receptor in isolated human ileum.
Topics: Bradykinin; Humans; Ileum; In Vitro Techniques; Kallidin; Muscle Contraction; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin | 1996 |
The role of the kallikrein-kinin system in type I diabetes (insulitis).
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Kallikrein-Kinin System; Male; Mice; Mice, Inbred C57BL; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin | 1996 |
Stimulus properties and antinociceptive effects of selective bradykinin B1 and B2 receptor antagonists in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Choice Behavior; Dose-Response Relationship, Drug; Formaldehyde; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1996 |
Effects of B1 and B2 kinin receptor antagonists in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Bradykinin; Bradykinin Receptor Antagonists; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred C57BL; Streptozocin | 1996 |
Different B1 kinin receptor expression and pharmacology in endothelial cells of different origins and species.
Topics: Animals; Aorta; Bradykinin; Bradykinin Receptor Antagonists; Cattle; Cells, Cultured; Coronary Vessels; Cyclic GMP; DNA Primers; Endothelium, Vascular; Humans; Microcirculation; Naphthalenes; Organophosphorus Compounds; Polymerase Chain Reaction; Rats; Receptor, Bradykinin B1; Receptors, Bradykinin; Species Specificity; Transcription, Genetic; Umbilical Veins | 1997 |
Bradykinin B1 receptors in human umbilical vein.
Topics: Anti-Inflammatory Agents; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Dexamethasone; Female; Humans; In Vitro Techniques; Muscle Contraction; Pregnancy; Receptor, Bradykinin B1; Receptors, Bradykinin; Umbilical Veins; Up-Regulation | 1997 |
Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Hindlimb; Hyperalgesia; Indomethacin; Joints; Male; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Receptors, Bradykinin | 1997 |
Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Edema; Female; Formaldehyde; Freund's Adjuvant; Hindlimb; Male; Mice; Mice, Transgenic; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Reflex | 1997 |
Induction of bradykinin B1 receptors in rat colonic epithelium.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Chloride Channels; Colon; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Dactinomycin; Epithelial Cells; Epithelium; In Vitro Techniques; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Transcription, Genetic | 1997 |
Evidence for bradykinin B2-receptors on cultured human decidua cells.
Topics: Adrenergic beta-Antagonists; Base Sequence; Binding, Competitive; Bradykinin; Bradykinin Receptor Antagonists; Cells, Cultured; Decidua; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunohistochemistry; Inflammation; Isotope Labeling; Labor, Induced; Molecular Sequence Data; Polymerase Chain Reaction; Pregnancy; Radioligand Assay; Receptor, Bradykinin B2; Receptors, Bradykinin; RNA, Messenger; Tritium | 1997 |
Expression of bradykinin B1 receptors in colonic epithelia.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Chlorides; Colon; Cycloheximide; Dactinomycin; Diuretics; Epithelium; Furosemide; In Vitro Techniques; Ion Channels; Ion Transport; Lethal Dose 50; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Receptor, Bradykinin B1; Receptors, Bradykinin; Transcription, Genetic | 1997 |
Daily variation in an intensity of kaolin-induced writhing reaction in mice.
Topics: Analgesia; Animals; Bradykinin; Bradykinin Receptor Antagonists; Circadian Rhythm; Kaolin; Kinetics; Male; Mice; Mice, Inbred ICR; Pain; Photoperiod | 1997 |
PGE2 release by bradykinin in human airway smooth muscle cells: involvement of cyclooxygenase-2 induction.
Topics: Adult; Arachidonic Acid; Bradykinin; Bradykinin Receptor Antagonists; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Female; Humans; Isoenzymes; Kinetics; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Prostaglandin-Endoperoxide Synthases; Receptors, Bradykinin; Trachea | 1997 |
Smokeless tobacco-exposed oral keratinocytes increase macromolecular efflux from the in situ oral mucosa.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Cells, Cultured; Cheek; Cricetinae; Dextrans; Fluorescein-5-isothiocyanate; Humans; Keratinocytes; Kinetics; Leupeptins; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Plants, Toxic; Tobacco, Smokeless | 1998 |
Biphasic response to bradykinin in isolated porcine iliac arteries is mediated by bradykinin B1 and B2 receptors.
Topics: 3-Mercaptopropionic Acid; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cilazapril; Cycloheximide; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enalaprilat; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Protease Inhibitors; Protein Synthesis Inhibitors; Receptors, Bradykinin; Swine; Vasoconstriction; Vasodilation | 1998 |
Characterisation of kinin receptors on the human isolated umbilical artery.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Bradykinin; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Adrenergic, beta-1; Umbilical Arteries | 1998 |
Effect of WIN 64338, a B2 bradykinin receptor antagonist on guinea-pig tracheal smooth muscle cells in culture.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Binding, Competitive; Bradykinin; Bradykinin Receptor Antagonists; Cells, Cultured; Fluorescent Antibody Technique; Guinea Pigs; Inositol Phosphates; Male; Muscle, Smooth; Naphthalenes; Oligopeptides; Organophosphorus Compounds; Receptor, Bradykinin B2; Receptors, Bradykinin; Trachea | 1998 |
The modulatory effects of bradykinin B1 and B2 receptor antagonists upon viscero-visceral hyper-reflexia in a rat model of visceral hyperalgesia.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coloring Agents; Cystitis; Evans Blue; Female; Hyperalgesia; Rats; Rats, Wistar; Reflex, Abnormal; Urinary Bladder; Viscera | 1998 |
B1 kinin receptor activity in pigs is associated with pre-existing infection.
Topics: Acetylcholine; Animals; Bacterial Infections; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Gram-Negative Bacteria; Heart Rate; Lipopolysaccharides; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Swine | 1998 |
Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice.
Topics: Animals; Bradykinin; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Edema; Formaldehyde; Hindlimb; Indomethacin; Kallidin; Male; Mice; Mycobacterium bovis; Pain; Pain Measurement; Pyrazoles; Receptor, Bradykinin B1; Receptors, Bradykinin | 1998 |
Kinin B1 receptor antagonists containing alpha-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities.
Topics: Animals; Blood Pressure; Bradykinin; Humans; Kallidin; Peptides; Peptidyl-Dipeptidase A; Phenylalanine; Plasma; Rabbits; Receptors, Neurokinin-3; Time Factors | 1999 |
Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Hyperalgesia; Indomethacin; Inflammation; Interleukin-8; Kallidin; Lipopolysaccharides; Male; Mice; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Sheep; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Response of fetal rabbit ductus arteriosus to bradykinin: role of nitric oxide, prostaglandins, and bradykinin receptors.
Topics: Animals; Animals, Newborn; Bradykinin; Dinoprostone; Ductus Arteriosus; Endothelium, Vascular; Female; In Vitro Techniques; Isometric Contraction; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Pregnancy; Prostaglandins; Rabbits; Receptors, Bradykinin | 1999 |
Tumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-joints.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Dinoprostone; Inflammation Mediators; Injections, Intra-Articular; Knee Joint; Male; Pain; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Tumor Necrosis Factor-alpha | 1999 |
Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Cell Movement; Drug Combinations; Female; Injections, Intradermal; Injections, Intravenous; Interleukin-1; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Neutrophils; Receptors, Neurokinin-1; Skin; Substance P; Zymosan | 2000 |
Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain.
Topics: Animals; Bradykinin; Constriction, Pathologic; Ganglia, Spinal; Hot Temperature; Lumbosacral Region; Male; Nervous System Diseases; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; RNA, Messenger; Sciatic Nerve; Wounds and Injuries | 2000 |
Lipopolysaccharide decreases bradykinin receptor-induced acidification responses in cultured bovine aortic endothelial cells.
Topics: Animals; Aorta, Thoracic; Bradykinin; Bradykinin Receptor Antagonists; Cattle; Cells, Cultured; Endothelium, Vascular; Endotoxins; Lipopolysaccharides; Quinolines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin | 2000 |
Targeting kinin B(1) receptor for therapeutic neovascularization.
Topics: Animals; Apoptosis; Bradykinin; Bradykinin Receptor Antagonists; Cell Division; Cells, Cultured; Endothelium, Vascular; Extremities; Humans; Ischemia; Laser-Doppler Flowmetry; Mice; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Perfusion; Receptor, Bradykinin B1; Receptors, Bradykinin; Signal Transduction | 2002 |
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
Topics: Allergens; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyproheptadine; Dinitrophenols; Dose-Response Relationship, Drug; Drug Synergism; Edema; Histamine; Histamine H1 Antagonists; Hyperalgesia; Immunoglobulin E; Male; Meclizine; Methysergide; Pain; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serum Albumin, Bovine; Time Factors | 2003 |
Bradykinin receptor subtype 1 expression and function in prostate cancer.
Topics: Biopsy; Bradykinin; Bradykinin Receptor Antagonists; Cell Division; Cell Movement; Enzyme Activation; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Prostatic Neoplasms; Receptors, Bradykinin; Signal Transduction | 2003 |
Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.
Topics: Airway Resistance; Allergens; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Guinea Pigs; Kallidin; Kinins; Leukotriene D4; Male; Nasal Lavage Fluid; Pollen; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Rhinitis, Allergic, Seasonal; Time Factors | 2003 |
Bradykinin B1 receptor stimulates the proximal tubule Na(+)-ATPase activity through protein kinase C pathway.
Topics: Adenosine Triphosphatases; Animals; Bradykinin; Cation Transport Proteins; Enzyme Inhibitors; Kidney Tubules, Proximal; Naphthalenes; Phosphatidylinositols; Phosphorylation; Phosphoserine; Protein Kinase C; Receptor, Bradykinin B1; Swine | 2003 |
Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation.
Topics: Alkaloids; Angiotensin-Converting Enzyme Inhibitors; Aorta; Benzophenanthridines; Bradykinin; Bradykinin B2 Receptor Antagonists; Cell Division; Cell Membrane; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Humans; Naphthalenes; Oxidative Stress; Phenanthridines; Protein Kinase C; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Thiazepines; Time Factors | 2003 |
Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.
Topics: Animals; Arachidonic Acids; Atenolol; Behavior, Animal; Biogenic Amines; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Captopril; Celecoxib; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Guanethidine; Hindlimb; Indomethacin; Injections, Subcutaneous; Interleukin-6; Interleukin-8; Lip; Male; Meloxicam; Nociceptors; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha; Tyramine | 2004 |
Bradykinin antagonists have no analgesic effect on incisional pain.
Topics: Analgesics; Animals; Behavior, Animal; Bradykinin; Dose-Response Relationship, Drug; Foot; Hot Temperature; Male; Pain Measurement; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2004 |
Reduced nerve injury-induced neuropathic pain in kinin B1 receptor knock-out mice.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Female; Functional Laterality; Gene Expression; Hyperalgesia; Male; Mice; Mice, Knockout; Neuralgia; Pain Measurement; Receptor, Bradykinin B1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Skin; Skin Temperature; Time Factors | 2005 |
Estrogens and glucocorticoids have opposing effects on the amount and latent activity of complement proteins in the rat uterus.
Topics: Animals; Body Fluids; Bradykinin; Complement C1 Inactivator Proteins; Complement C1 Inhibitor Protein; Complement System Proteins; Dexamethasone; Escherichia coli; Estradiol; Estrogens; Female; Glucocorticoids; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Serpins; Uterus | 2006 |
Ca2+-dependent K+ channels are targets for bradykinin B1 receptor ligands and for lipopolysaccharide in the rat aorta.
Topics: Animals; Aorta; Bradykinin; Bradykinin B1 Receptor Antagonists; Calcium; Calcium-Transporting ATPases; In Vitro Techniques; Kallidin; Ligands; Lipopolysaccharides; Male; Membrane Potentials; Myocytes, Smooth Muscle; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar; Receptor, Bradykinin B1; Thapsigargin | 2005 |
Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model.
Topics: Animals; Bone Neoplasms; Bradykinin; Bradykinin B1 Receptor Antagonists; Injections, Subcutaneous; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Pain; Sarcoma | 2005 |
Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Asthma; Blood Pressure; Bradykinin; Capsaicin; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Guinea Pigs; Heart Rate; Indomethacin; Lung; Nerve Fibers, Unmyelinated; Prostaglandins; Respiratory Hypersensitivity; Substance P | 2006 |
Peripheral kinin B(1) and B(2) receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats.
Topics: Animals; Behavior, Animal; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Drug Administration Routes; Functional Laterality; Hyperalgesia; Ligation; Male; Neuralgia; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Spinal Nerves; Time Factors | 2007 |
TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor.
Topics: Animals; Antibodies; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Bradykinin Receptor Antagonists; Carrageenan; Dose-Response Relationship, Drug; Guanethidine; Hyperalgesia; Indomethacin; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandins; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha | 2007 |
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Calcium; Cell Movement; Cells, Cultured; Cerebellar Cortex; Chemotaxis; Dose-Response Relationship, Drug; Mice; Mice, Knockout; Microglia; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Signal Transduction; Sodium-Calcium Exchanger; Time Factors | 2007 |
Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis.
Topics: Angiogenesis Inducing Agents; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillaries; Enzyme Inhibitors; Hindlimb; Imidazoles; Imidazolidines; Ischemia; Male; Mice; Mice, Knockout; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Reaction Time; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Time Factors | 2008 |
Kinin B(1) and B(2) receptors contribute to orofacial heat hyperalgesia induced by infraorbital nerve constriction injury in mice and rats.
Topics: Analysis of Variance; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Cranial Nerve Injuries; Facial Pain; Hot Temperature; Hyperalgesia; Male; Maxillary Nerve; Mice; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2 | 2010 |
Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Cell Line, Tumor; Endothelin-1; Gene Expression; Gene Expression Regulation, Neoplastic; Melanoma, Experimental; Mice; Receptor, Bradykinin B1; Receptor, Bradykinin B2 | 2010 |
The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice.
Topics: Animals; Antipruritics; Behavior, Animal; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intradermal; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Pain Threshold; Pruritus; Quinolines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptor, PAR-2; Sulfonamides; Trypsin | 2010 |
Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.
Topics: Abdominal Pain; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Dynorphins; Ganglia, Spinal; Gene Expression; Immune Sera; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Male; Organotin Compounds; Pain; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord | 2010 |
Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis.
Topics: Actinin; Albuminuria; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Glomerulosclerosis, Focal Segmental; Heme Oxygenase-1; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Macrophages; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred BALB C; Podocytes; Receptor, Bradykinin B1; RNA, Messenger; Signal Transduction; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2011 |
Anti-nociceptive effect of kinin B₁ and B₂ receptor antagonists on peripheral neuropathy induced by paclitaxel in mice.
Topics: Analgesics; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Hyperalgesia; Kinins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Paclitaxel; Peripheral Nervous System Diseases; Receptor, Bradykinin B1; Receptor, Bradykinin B2; RNA, Messenger | 2011 |
Exacerbation of DSS-induced colitis in mice lacking kinin B(1) receptors through compensatory up-regulation of kinin B(2) receptors: the role of tight junctions and intestinal homeostasis.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Colitis; Cytokines; Dextran Sulfate; Dioxoles; Homeostasis; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sulfonamides; Tight Junctions; Up-Regulation | 2013 |
HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Motor Activity; NADPH Oxidases; Neuroprotective Agents; Oxidative Stress; Recognition, Psychology; Time Factors | 2014 |
Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Dynorphins; Facial Pain; Hot Temperature; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neurotransmitter Agents; Pain Measurement; Receptors, Bradykinin; Touch | 2015 |
Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats.
Topics: Aging; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory Disorders; Rats; Rats, Wistar; Receptor, Bradykinin B1; Spatial Learning; Up-Regulation | 2017 |
Blockade of the kinin B1 receptor affects the cytokine/chemokine profile in rat brain subjected to autoimmune encephalomyelitis.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Brain; Chemokines; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Rats; Rats, Inbred Lew; Receptor, Bradykinin B1 | 2017 |