Page last updated: 2024-09-05

boswellic acid and acetyl-11-ketoboswellic acid

boswellic acid has been researched along with acetyl-11-ketoboswellic acid in 25 studies

Compound Research Comparison

Studies
(boswellic acid)
Trials
(boswellic acid)
Recent Studies (post-2010)
(boswellic acid)
Studies
(acetyl-11-ketoboswellic acid)
Trials
(acetyl-11-ketoboswellic acid)
Recent Studies (post-2010) (acetyl-11-ketoboswellic acid)
22715147137298
605137298

Protein Interaction Comparison

ProteinTaxonomyboswellic acid (IC50)acetyl-11-ketoboswellic acid (IC50)
Prostaglandin E synthaseHomo sapiens (human)3
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.7
Prolyl endopeptidaseHomo sapiens (human)7.89

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.00)18.2507
2000's6 (24.00)29.6817
2010's12 (48.00)24.3611
2020's6 (24.00)2.80

Authors

AuthorsStudies
Choudhary, MI; Fatima, N; Kimbu, SF; Makhmoor, T; Naz, H; Ngounou, FN; Sondengam, BL; Yasin, A1
Gupta, P; Kumar, A; Qazi, GN; Saxena, AK; Sethi, VK; Shah, BA; Sharma, M; Singh, J; Taneja, SC1
Chib, R; Kaur, R; Kaur, T; Khan, S; Shah, BA; Sharma, PR; Singh, J; Taneja, SC1
Hamid, A; Kumar, A; Saxena, AK; Sethi, VK; Shah, BA; Singh, J; Singh, S; Singh, SK; Taneja, SC1
Abdel-Tawab, M; Fricker, G; Gerbeth, K; Hüsch, J; Rebmann, H; Schubert-Zsilavecz, M; Setzer, C; Zirkel, J1
Jauch, J; Noha, SM; Paul, M; Schuster, D; Seitz, S; Verhoff, M; Werz, O1
Ahmed, Z; Bhagat, A; Gupta, S; Khajuria, V; Shah, BA; Sharma, S1
Atanasov, AG; Kamal, MA; Khan, H; Nabavi, SM; Pervaiz, A; Rengasamy, KRR1
Fukushima, EO; Muranaka, T; Nomura, Y; Vo, NNQ1
Ammon, HP; Glaser, T; Groscurth, P; Safayhi, H; Sailer, ER; Schabet, M; Weller, M; Winter, S1
Anthoni, C; Boden, SE; Krieglstein, CF; Laukötter, M; Rijcken, EJ; Safayhi, H; Schürmann, G; Schweizer, S; Senninger, N; Spiegel, HU1
Cui, R; Zhou, JY1
Jauch, J; Kather, N; Poeckel, D; Tausch, L; Werz, O1
Ivanova, SA; Makarov, VG; Pozharitskaya, ON; Shikov, AN1
Gu, BR; Jin, HY; Ma, SC; Sun, L; Tian, RT; Zhang, C1
Abdel-Tawab, M; Artaria, C; Meins, J; Morazzoni, P; Riva, A; Schubert-Zsilavecz, M1
Maffei, ME; Mannino, G; Occhipinti, A1
Jauch, J; Koeberle, A; Northoff, H; Paul, M; Poeckel, D; Siemoneit, U; Tausch, L; Werz, O1
Al-Harrasi, A; Al-Rawahi, A; Al-Shidhani, S; Badshah, A; Csuk, R; Fischer, L; Hussain, H; Hussain, J; Khan, A; Khan, HY; Saeed, A; Shamraiz, U; Ur Rehman, N1
Majeed, M; Majeed, S; Nagabhushanam, K; Narayanan, NK1
Greve, HL; Kaiser, M; Mäser, P; Schmidt, TJ1
Al-Harrasi, A; Al-Hashmi, S; Al-Kindi, J; Al-Riyami, K; Alam, K; Arefian, E; Csuk, R; Ghaemi, S; Jamshidi-Adegani, F; Rehman, NU; Vakilian, S1
Börner, F; Gerstmeier, J; Gilbert, NC; Gomez, M; Jordan, PM; Newcomer, ME; Pace, S; Rossi, A; Werz, O1
Kumar, A; Mishra, S; Ojha, S; Sharma, S; Upadhyay, P1
Al-Harrasi, A; Elkord, E; Meyiah, A; Shawkat, MY; Ur Rehman, N1

Reviews

2 review(s) available for boswellic acid and acetyl-11-ketoboswellic acid

ArticleYear
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
    European journal of medicinal chemistry, 2018, Jun-10, Volume: 153

    Topics: Animals; Anti-Inflammatory Agents; Biological Products; Drug Discovery; Enzyme Inhibitors; Humans; Inflammation; Plants, Medicinal; Prostaglandin-E Synthases

2018
ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency.
    Anti-cancer agents in medicinal chemistry, 2023, Volume: 23, Issue:13

    Topics: Anti-Inflammatory Agents; Boswellia; Humans; Plant Extracts; Structure-Activity Relationship; Triterpenes

2023

Trials

1 trial(s) available for boswellic acid and acetyl-11-ketoboswellic acid

ArticleYear
A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.
    Phytotherapy research : PTR, 2019, Volume: 33, Issue:5

    Topics: Aged; Boswellia; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Pilot Projects; Plant Extracts; Triterpenes

2019

Other Studies

22 other study(ies) available for boswellic acid and acetyl-11-ketoboswellic acid

ArticleYear
Bioactive constituents from Boswellia papyrifera.
    Journal of natural products, 2005, Volume: 68, Issue:2

    Topics: Boswellia; Cameroon; Enzyme Inhibitors; Glycosides; Inhibitory Concentration 50; Molecular Structure; Plants, Medicinal; Stilbenes; Triterpenes

2005
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
    Bioorganic & medicinal chemistry letters, 2007, Dec-01, Volume: 17, Issue:23

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Boswellia; Cell Line, Tumor; DNA Fragmentation; Growth Inhibitors; Humans; Triterpenes

2007
A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; HeLa Cells; HL-60 Cells; Humans; Nitriles; Oxygen; Triterpenes

2011
Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Flow Cytometry; HL-60 Cells; Humans; Models, Chemical; NF-kappa B; Phosphorylation; STAT Transcription Factors; Triterpenes

2012
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
    Journal of natural products, 2012, Oct-26, Volume: 75, Issue:10

    Topics: Absorption; Administration, Oral; Animals; Boswellia; Brain; Caco-2 Cells; Humans; Male; Models, Biological; Permeability; Phospholipids; Poloxamer; Polysorbates; Rats; Solubility; Time Factors; Triterpenes; Vitamin E

2012
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
    Journal of natural products, 2014, Jun-27, Volume: 77, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Boswellia; Characidae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Molecular Structure; Pentacyclic Triterpenes; Prostaglandin Antagonists; Prostaglandin-E Synthases; Resins, Plant; Structure-Activity Relationship; Tetracycline; Triterpenes

2014
Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Humans; Interleukin-6; Mice; Triterpenes; Tumor Necrosis Factor-alpha

2016
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
    Journal of natural products, 2019, 12-27, Volume: 82, Issue:12

    Topics: Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Lipoxygenase Inhibitors; Pentacyclic Triterpenes; Structure-Activity Relationship

2019
Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity.
    British journal of cancer, 1999, Volume: 80, Issue:5-6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Resistance, Neoplasm; Drug Synergism; Fas Ligand Protein; Glioma; Humans; Membrane Glycoproteins; Mice; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis.
    International journal of colorectal disease, 2001, Volume: 16, Issue:2

    Topics: Animals; Disease Models, Animal; Follow-Up Studies; Ileitis; Inflammatory Bowel Diseases; Male; Plant Extracts; Plants, Medicinal; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Resins, Plant; Sensitivity and Specificity; Treatment Outcome; Triterpenes

2001
[Chemical components of Boswellia carterii].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Boswellia; Cell Division; HL-60 Cells; Humans; Molecular Structure; Plants, Medicinal; Triterpenes

2002
Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.
    Molecular pharmacology, 2006, Volume: 70, Issue:3

    Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Calcium; Cell-Free System; Humans; Kinetics; Leukotrienes; Phospholipases A; Phospholipases A2; Signal Transduction; Triterpenes

2006
Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).
    Journal of separation science, 2006, Volume: 29, Issue:14

    Topics: Boswellia; Chromatography, Thin Layer; Plant Extracts; Reference Standards; Silicon Dioxide; Solvents; Terpenes; Triterpenes

2006
Combination of quantitative analysis and chemometric analysis for the quality evaluation of three different frankincenses by ultra high performance liquid chromatography and quadrupole time of flight mass spectrometry.
    Journal of separation science, 2015, Volume: 38, Issue:19

    Topics: Boswellia; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Frankincense; Mass Spectrometry; Triterpenes

2015
Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids.
    Planta medica, 2016, Volume: 82, Issue:6

    Topics: Boswellia; Dietary Supplements; Europe; Food Quality; Molecular Structure; Resins, Plant; Surveys and Questionnaires; Triterpenes; United States

2016
Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb.
    Molecules (Basel, Switzerland), 2016, Oct-06, Volume: 21, Issue:10

    Topics: Boswellia; Chromatography, High Pressure Liquid; Limit of Detection; Molecular Structure; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triterpenes

2016
Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.
    Planta medica, 2017, Volume: 83, Issue:12-13

    Topics: Anti-Inflammatory Agents; Blood Platelets; Boswellia; Calcium; Humans; Plant Extracts; Structure-Activity Relationship; Triterpenes

2017
Synthesis of new boswellic acid derivatives as potential antiproliferative agents.
    Natural product research, 2020, Volume: 34, Issue:13

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dimerization; Female; Humans; Ovarian Neoplasms; Triterpenes

2020
Boswellic Acids Show In Vitro Activity against
    Molecules (Basel, Switzerland), 2021, Jun-15, Volume: 26, Issue:12

    Topics: Animals; Cell Line; Humans; Inhibitory Concentration 50; Leishmania donovani; Macrophages; Mice; Plant Extracts; Rats; Resins, Plant; Triterpenes

2021
Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer.
    Scientific reports, 2022, 11-21, Volume: 12, Issue:1

    Topics: Epigenesis, Genetic; Epigenomics; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53

2022
Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023, Volume: 10, Issue:6

    Topics: Allosteric Regulation; Animals; Arachidonate 15-Lipoxygenase; HEK293 Cells; Humans; Inflammation; Lipids; Lipoxygenase; Mice; Scavenger Receptors, Class E

2023
Effect of Boswellic acids on T cell proliferation and activation.
    International immunopharmacology, 2023, Volume: 122

    Topics: CD8-Positive T-Lymphocytes; Cell Proliferation; Humans; Leukocytes, Mononuclear; Lymphocyte Activation

2023