bosentan anhydrous has been researched along with taurocholic acid in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Ayasse, D; Fiedler, F; Gretz, N; Keim, V; Rehbein, C; Rohmeiss, P | 1 |
| Fattinger, K; Funk, C; Meier, PJ; Pantze, M; Reichen, J; Stieger, B; Weber, C | 1 |
| Brouwer, KL; Kemp, DC; Zamek-Gliszczynski, MJ | 1 |
| Kamimura, H; Mano, Y; Usui, T | 1 |
| Brouwer, KL; Kim, RB; Leslie, EM; Watkins, PB | 1 |
| Brouwer, K; Gorczynski, R; Hartman, JC; Mandagere, A; Melvin, L | 1 |
| Baranyai, Z; Jakab, F; Jemnitz, K; Szabo, M; Vereczkey, L; Veres, Z | 1 |
| Baranyai, Z; Jakab, F; Jemnitz, K; Szabo, M; Veres, Z | 1 |
| Brouwer, KR; Gillies, H; Hao, J; Hubert, C; Lepist, EI; Ray, AS; Smith, W; St Claire, RL | 1 |
10 other study(ies) available for bosentan anhydrous and taurocholic acid
| Article | Year |
|---|---|
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
The endothelin antagonist bosentan does not improve survival in severe experimental pancreatitis in rats.
Topics: Animals; Bile Acids and Salts; Bosentan; Endothelins; Female; Pancreatitis, Acute Necrotizing; Random Allocation; Rats; Rats, Wistar; Sulfonamides; Taurocholic Acid; Treatment Failure | 1999 |
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions.
Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bile Canaliculi; Bosentan; Cholestasis, Intrahepatic; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Combinations; Endothelin Receptor Antagonists; Glyburide; Humans; Hypertension; Liver; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfonamides; Taurocholic Acid | 2001 |
Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes.
Topics: Animals; Bile Canaliculi; Bosentan; Cardiovascular Agents; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Drug Combinations; Hepatocytes; Male; Rats; Rats, Wistar; Sulfonamides; Taurocholic Acid; Thiazolidinediones; Troglitazone | 2005 |
Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cytoplasmic Vesicles; Endothelin Receptor Antagonists; Estradiol; Humans; Multidrug Resistance-Associated Protein 2; Rats; Spodoptera; Sulfonamides; Taurocholic Acid | 2007 |
Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.
Topics: Animals; Antihypertensive Agents; Biological Transport; Biotinylation; Bosentan; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Kinetics; Male; Middle Aged; Models, Biological; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Wistar; Recombinant Fusion Proteins; Sulfonamides; Symporters; Taurocholic Acid; Transfection | 2007 |
Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Bosentan; Cell Culture Techniques; Cells, Cultured; Endothelin Receptor Antagonists; Enkephalin, D-Penicillamine (2,5)-; Estradiol; Female; Hepatocytes; Humans; Isoxazoles; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenylpropionates; Pyridazines; Pyrimidines; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes; Young Adult | 2010 |
Differential inhibitory effect of cyclosporin A and bosentan on taurocholate uptake in human and rat hepatocytes as a function of culturing time.
Topics: Aged; Animals; Biological Transport; Bosentan; Cells, Cultured; Cyclosporine; Female; Hepatocytes; Humans; Male; Middle Aged; Rats; Rats, Wistar; Sulfonamides; Taurocholic Acid; Time Factors | 2012 |
Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity.
Topics: Animals; Biological Transport; Bosentan; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Chromans; Cyclosporine; Hepatocytes; Humans; Rats; Sulfobromophthalein; Sulfonamides; Taurocholic Acid; Thiazolidinediones; Troglitazone | 2013 |
Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Bosentan; Endothelin Receptor Antagonists; Female; Hepatocytes; Humans; Isoxazoles; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Phenylpropionates; Pyridazines; Pyrimidines; Receptors, Endothelin; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes | 2014 |