Page last updated: 2024-08-26

bosentan anhydrous and lu 208075

bosentan anhydrous has been researched along with lu 208075 in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (16.30)	29.6817
2010's	70 (76.09)	24.3611
2020's	7 (7.61)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Auld, DS; Austin, CP; Huang, R; Moeller, TA; Sakamuru, S; Shinn, P; Shukla, SJ; Vanleer, D; Xia, M	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Lei, X; Song, J; Sun, H; Wang, Q; Xia, J; Zhang, X; Zhen, L; Zheng, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bolli, MH; Boss, C; Gatfield, J	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Hoeper, MM	1
Langleben, D	1
Dupuis, J; Hoeper, MM	1
Amoura, Z; Cacoub, P; Langleben, D	1
Batyraliev, TA; Ekinsi, E; Makhmutkhodzhaev, SA; Pataraia, SA; Pershukov, IV; Preobrazhenskiĭ, DV; Sidorenko, BA	1
Howard, LS; Price, LC	1
Ewert, R; Kirch, W; Opitz, CF; Pittrow, D	1
Arzt, M; Blumberg, FC; Budweiser, S; Luchner, A; Pfeifer, M; Schroll, S; Sebah, D; Stoelcker, B	1
Coghlan, G; Kabunga, P	1
Badesch, DB; Despain, DJ; Dufton, C; Frost, AE; Galie, N; Gerber, MJ; McGoon, MD; McLaughlin, VV; Olschewski, H; Oudiz, RJ; Rubin, LJ	1
Stähler, G	1
Preston, IR; Steiner, MK	1
Mucke, HA	1
Dranitsaris, G; Mehta, S	1
Coles, WA; Gladwin, MT; Kato, GJ; Machado, RF; Minniti, CP; Sachdev, V	1
Humbert, M; Montani, D	1
Hunsche, E; Lefebvre, MC	1
Brouwer, K; Gorczynski, R; Hartman, JC; Mandagere, A; Melvin, L	1
Brown, K; Dalton, B; Gabbay, E; Keogh, A; Kermeen, F; Kilpatrick, D; Kotlyar, E; Macdonald, P; Pidoux, A; Steele, P; Strange, G; Williams, T	1
Derk, CT; Shetty, N	1
Haefeli, WE; Herzog, M; Weiss, J	1
Humbert, M; Jaïs, X; Montani, D; Natali, D; O'Callaghan, DS; Parent, F; Savale, L; Simonneau, G; Sitbon, O; Yaïci, A	1
Bräuer, R; Gajda, M; Glück, L; Imhof, AK; Schaible, HG; Schulz, S	1
Andreassen, AK; Gude, E; Solberg, OG; Ueland, T	1
French, B; Gabler, NB; Halpern, SD; Kawut, SM; Liu, Z; Palevsky, HI; Strom, BL; Taichman, DB	1
Franklin, WJ; Parekh, DR; Safdar, Z	1
Allard, M; Dufton, C; Gillies, H; Regnault, J; Venitz, J; Zack, J	1
Brady, D; Calderbank, M; Ivy, DD; Rosenzweig, EB; Takatsuki, S; Zuckerman, W	1
Blenkhorn, F; Eisenberg, MJ; Fox, B; Hirsch, AM; Joyal, D; Langleben, D; Lesenko, L; Schlesinger, RD	1
Fedele, F; Pezzuto, B; Rubin, LJ; Vizza, CD	1
Rubin, LJ	1
Luo, N; Ryan, JJ	1
Clozel, M; Gatfield, J; Mueller Grandjean, C; Nayler, O; Sasse, T	1
Burhenne, J; Haefeli, WE; Riedel, KD; Spalwisz, A; Theile, D; Weiss, J	1
Berrevoet, F; Colle, I; De Pauw, M; Geerts, A; Raevens, S; Reyntjens, K; Rogiers, X; Troisi, RI; Van Vlierberghe, H; Verhelst, X	1
Bouras, G; Cleman, MW; Deftereos, S; Giannopoulos, G; Kaoukis, A; Panagopoulou, V; Papoutsidakis, N; Raisakis, K; Stefanadis, C	1
Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero Corominas, D	1
Behr, J; Jungck, D; Knobloch, J; Koch, A; Konradi, J; Lin, Y; Stoelben, E; Strauch, J	1
Behr, J; Feldmann, M; Jungck, D; Knobloch, J; Koch, A; Stoelben, E; Wahl, C	1
Barbaro Foschino, MP; Brunetti, ND; Correale, M; Di Biase, M; Lacedonia, D; Montrone, D; Totaro, A	1
Humbert, M; Jardim, C; Souza, R	1
Belperio, JA; Fishbein, MC; Lynch, JP; Saggar, R	1
Hayashi, H; Hirai, K; Itoh, K; Ono, Y; Todoroki, K; Tomatsuri, M; Toyo'oka, T; Yamada, H; Yamada, Y; Yokoyama, Y	1
Deguchi, Y; Hayashi, H; Ito, Y; Itoh, K; Okura, T; Osano, A; Yamada, S; Yokoyama, Y	2
Brouwer, KR; Gillies, H; Hao, J; Hubert, C; Lepist, EI; Ray, AS; Smith, W; St Claire, RL	1
Kanda, T; Naito, A; Sakao, S; Sugiura, T; Tanabe, N; Tatsumi, K; Terada, J; Yokosuka, O	1
Watanabe, H	1
Baloira Villar, A; Núñez Fernández, M; Pousada Fernández, G; Valverde Pérez, D	1
Davenport, AP; Maguire, JJ	1
Burhenne, J; Haefeli, WE; Hellwig, R; Markert, C; Mikus, G; Riedel, KD; Weiss, J; Wirsching, T	1
Andersson, LC; Bergare, J; Billger, M; Eakins, JA; Elebring, M; Elmore, CS; Foster, AJ; Kenna, JG; Stahl, SH; Thompson, RA	1
Baumann, S; Haefeli, WE; Theile, D; Weiss, J	1
Dingemanse, J; Krähenbühl, S; Sidharta, PN	1
Yao, A	1
Aversa, M; Granton, J; Porter, S	1
Jungck, D; Knobloch, J; Koch, A; Konradi, J; Körber, S; Lin, Y; Stoelben, E; Yanik, S	1
Fujita, J; Fukuda, K; Kataoka, M; Kimura, M; Kuwana, M; Ono, T; Satoh, T; Takei, M; Tamura, Y; Yamamoto, T	1
Hatano, M; Imamura, T; Kinugawa, K; Komuro, I; Maki, H; Muraoka, H; Yao, A	1
Cocco, N; Madonna, R	1
Berger, JT; Grant, EK	1
Burhenne, J; Enderle, Y; Friedrich, J; Grünig, E; Haefeli, WE; Meid, AD; Wilkens, H	1
Goldberg, DJ; Paridon, SM; Rychik, J; Snarr, BS	1
Hakamata, A; Inui, N; Irisawa, H; Miyakawa, S; Odagiri, K; Takeuchi, K; Tanaka, S; Uchida, S; Watanabe, H	1
Canestaro, WJ; Devine, BE; Forrester, SH; Ho, L; Raghu, G	1
Lejnieks, A; Lesina, K; Rudzitis, A; Sablinskis, K; Skride, A	1
Bauer, F; Bergot, E; Bertoletti, L; Bourdin, A; Bouvaist, H; Chabannes, C; Chaouat, A; Cottin, V; Dauphin, C; De Groote, P; Humbert, M; Jaïs, X; Montani, D; Sattler, C; Savale, L; Simonneau, G; Sitbon, O	1
Chuang, CL; Hsin, IF; Hsu, SJ; Huang, HC; Lee, FY; Lee, JY; Lee, SD; Lin, HC; Lin, TY; Wang, SS	1
Chen, M; Chen, Q; Hu, G; Pan, P; Song, W; Wang, S; Xu, T; Zheng, Z	1
Angus, JA; Hughes, RJA; Soeding, PF; Wright, CE	1
Benjamin, N; Burhenne, J; Egenlauf, B; Enderle, Y; Fischer, C; Grünig, E; Haefeli, WE; Harutyunova, S; Huppertz, A; Klose, H; Ohnesorge, J	1
Behr, J; Bonella, F; Costabel, U; Geißler, K; Günther, A; Koschel, D; Kreuter, M; Müller-Quernheim, J; Prasse, A; Schönfeld, N; Sitter, H	1
Coghlan, C; Coghlan, JG; Dawson, A; Reddecliffe, S; Schreiber, BE	1
Gong, SG; He, J; Jiang, R; Liu, JM; Pudasaini, B; Wang, L; Wu, WH; Yuan, P; Zhang, R; Zhao, QH; Zhou, CC	1
Dweik, RA; Heresi, GA; Highland, KB; Love, TE; Tonelli, AR	1
Chen, J; Liu, J; Qian, X; Tang, W; Xie, T; You, R; Zeng, F; Zhang, Y	1
Kuang, HY; Li, Q; Lu, TW; Wu, YH; Yi, QJ	1
Jiang, X; Jing, ZC; Xu, XQ	1
Sakao, S	1
Batcioglu, K; Dokur, M; Gurer, AO; Karadag, M; Kazimoglu, H; Petekkaya, E; Uysal, E; Uyumlu, BA	1
Amiya, E; Hara, T; Hatano, M; Hosoya, Y; Inaba, T; Kinugawa, K; Komuro, I; Maki, H; Minatsuki, S; Morita, H; Saito, A; Tsuji, M; Yao, A	1
Kam, CW; Ruiz, FE	1
Chen, J; Guo, N; Parks, D; Tian, Z; Zhao, Q	1
Ceriani, F; Cosentino, M; De Ponti, R; Ferrari, M; Imporzani, A; Lattanzio, M; Marino, F; Martini, S	1
Amann, U; Haug, U; Kollhorst, B	1

Reviews

31 review(s) available for bosentan anhydrous and lu 208075

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective. Bioorganic & medicinal chemistry letters, 2016, 08-01, Volume: 26, Issue:15 Topics: Bosentan; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pyrimidines; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides	2016
[Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. Deutsche medizinische Wochenschrift (1946), 2006, Dec-08, Volume: 131, Issue:49 Suppl 9 Topics: Algorithms; Antihypertensive Agents; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Survival Rate; Thiophenes	2006
Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. Clinics in chest medicine, 2007, Volume: 28, Issue:1 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes	2007
Endothelin receptor antagonists in pulmonary arterial hypertension. The European respiratory journal, 2008, Volume: 31, Issue:2 Topics: Animals; Bosentan; Clinical Trials, Phase III as Topic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Prognosis; Pyridazines; Randomized Controlled Trials as Topic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Severity of Illness Index; Sulfonamides; Survival Rate; Thiophenes; Treatment Outcome	2008
[Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. La Revue de medecine interne, 2008, Volume: 29, Issue:4 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
[Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. Kardiologiia, 2007, Volume: 47, Issue:7 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Ventricular Dysfunction, Right	2007
Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2008, Volume: 8, Issue:3 Topics: Antihypertensive Agents; Bosentan; Clinical Trials, Phase III as Topic; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2008
Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? European heart journal, 2008, Volume: 29, Issue:16 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Phenylpropionates; Pulmonary Artery; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance; Walking	2008
Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. Drugs, 2008, Volume: 68, Issue:12 Topics: Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2008
[Specific drugs for the treatment of pulmonary arterial hypertension - current status]. Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133 Suppl 6 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostaglandins; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Thiophenes; Vasodilator Agents	2008
Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. Vascular health and risk management, 2008, Volume: 4, Issue:5 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Patient Compliance; Patient Satisfaction; Phenylpropionates; Pyridazines; Quality of Life; Receptors, Endothelin; Sulfonamides; Thiophenes; Treatment Outcome	2008
Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. IDrugs : the investigational drugs journal, 2009, Volume: 12, Issue:6 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Design; Endothelin Receptor Antagonists; Endothelins; Humans; Hypertension, Pulmonary; Isoxazoles; Patents as Topic; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2009
Endothelin receptor antagonists as disease modifiers in systemic sclerosis. Inflammation & allergy drug targets, 2011, Volume: 10, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Familial Primary Pulmonary Hypertension; Fibrosis; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2011
Endothelin receptor antagonists for the treatment of pulmonary arterial hypertension. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:10 Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Sulfonamides	2011
Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. Journal of clinical pharmacology, 2012, Volume: 52, Issue:12 Topics: Animals; Antihypertensive Agents; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Sulfonamides	2012
Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life sciences, 2012, Oct-15, Volume: 91, Issue:13-14 Topics: Administration, Oral; Animals; Antihypertensive Agents; Bosentan; Drug Design; Drug Monitoring; Endothelin Receptor Antagonists; Endothelin-1; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Sulfonamides	2012
The role of endothelin system in cardiovascular disease and the potential therapeutic perspectives of its inhibition. Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2 Topics: Animals; Atherosclerosis; Atrial Fibrillation; Bosentan; Cardiovascular Diseases; Coronary Artery Disease; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Hypertension, Pulmonary; Phenylpropionates; Predictive Value of Tests; Pyridazines; Receptors, Endothelin; Sulfonamides	2013
[Hepatotoxicity in patients treated with endothelin receptor antagonists: systematic review and meta-analysis of randomized clinical trials]. Medicina clinica, 2014, Apr-22, Volume: 142, Issue:8 Topics: Antihypertensive Agents; Biomarkers; Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Thiophenes; Transaminases	2014
Novelty in treatment of pulmonary fibrosis: pulmonary hypertension drugs and others. Cardiovascular & hematological agents in medicinal chemistry, 2013, Volume: 11, Issue:3 Topics: Antihypertensive Agents; Bosentan; Humans; Isoxazoles; Phenylpropionates; Phosphodiesterase Inhibitors; Pulmonary Fibrosis; Pyridazines; Sulfonamides; Thiophenes	2013
[Pharmacological treatment of pulmonary hypertension at a turning point]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2014, Volume: 143, Issue:4 Topics: Administration, Oral; Adult; Antihypertensive Agents; Bosentan; Carbolines; Endothelin Receptor Antagonists; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Infusions, Intravenous; Male; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Purines; Pyridazines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Vascular Resistance; Vasodilator Agents	2014
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. British journal of pharmacology, 2014, Volume: 171, Issue:24 Topics: Antineoplastic Agents; Aspartic Acid Endopeptidases; Benzazepines; Bosentan; Endothelin A Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelin-Converting Enzymes; Endothelins; Epigenesis, Genetic; Humans; Hypertension, Pulmonary; Metalloendopeptidases; Neoplasms; Peptide Fragments; Phenylpropionates; Pyridazines; Pyrimidines; Receptor, Endothelin B; Sulfonamides; Vasodilator Agents	2014
Pharmacokinetic and pharmacodynamic evaluation of macitentan , a novel endothelin receptor antagonist for the treatment of pulmonary arterial hypertension. Expert opinion on drug metabolism & toxicology, 2015, Volume: 11, Issue:3 Topics: Animals; Bosentan; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Pyrimidines; Sulfonamides	2015
Comparative safety and tolerability of endothelin receptor antagonists in pulmonary arterial hypertension. Drug safety, 2015, Volume: 38, Issue:5 Topics: Animals; Antihypertensive Agents; Bosentan; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Monitoring; Endothelin Receptor Antagonists; Heart Failure; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Pyrimidines; Risk; Sulfonamides	2015
Novel Strategies in the Treatment of Pulmonary Arterial Hypertension. Current drug targets, 2016, Volume: 17, Issue:7 Topics: Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Phenylpropionates; Prognosis; Pulmonary Circulation; Pyridazines; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome; Vascular Resistance	2016
Pulmonary vasodilator therapy in the failing Fontan circulation: rationale and efficacy. Cardiology in the young, 2015, Volume: 25, Issue:8 Topics: Bosentan; Cardiac Output; Endothelin Receptor Antagonists; Fontan Procedure; Heart Defects, Congenital; Heart Failure; Humans; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Postoperative Complications; Pulmonary Circulation; Pyridazines; Sildenafil Citrate; Sulfonamides; Vascular Resistance; Vasodilator Agents	2015
Drug Treatment of Idiopathic Pulmonary Fibrosis: Systematic Review and Network Meta-Analysis. Chest, 2016, Volume: 149, Issue:3 Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Azathioprine; Bayes Theorem; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; Etanercept; Free Radical Scavengers; Humans; Idiopathic Pulmonary Fibrosis; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Interferon-gamma; Phenylpropionates; Pyridazines; Pyridones; Pyrimidines; Recombinant Proteins; Sulfonamides; Vital Capacity; Warfarin	2016
Cost Effectiveness of Bosentan for Pulmonary Arterial Hypertension: A Systematic Review. Canadian respiratory journal, 2018, Volume: 2018 Topics: Antihypertensive Agents; Bosentan; Cost-Benefit Analysis; Endothelin Receptor Antagonists; Epoprostenol; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Sildenafil Citrate; Vasodilator Agents	2018
What is the position of pulmonary arterial hypertension-specific drug therapy in patients with Eisenmenger syndrome: A systematic review and meta-analysis. Medicine, 2019, Volume: 98, Issue:20 Topics: Antihypertensive Agents; Bosentan; Eisenmenger Complex; Endothelin Receptor Antagonists; Exercise Tolerance; Hemodynamics; Humans; Hypertension, Pulmonary; Oxygen; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Prostaglandins; Pyridazines; Pyrimidines; Sulfonamides	2019
Opportunities and challenges of pharmacotherapy for pulmonary arterial hypertension in children. Pediatric pulmonology, 2021, Volume: 56, Issue:3 Topics: Adolescent; Adult; Bosentan; Calcium Channel Blockers; Child; Child, Preschool; Epoprostenol; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Iloprost; Infant; Infant, Newborn; Phenotype; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Prognosis; Pulmonary Arterial Hypertension; Pyridazines; Pyrimidines; Receptors, Endothelin; Sildenafil Citrate; Sulfonamides; Tadalafil; Young Adult	2021
Comparative assessment of efficacy and safety of ambrisentan and bosentan in patients with pulmonary arterial hypertension: A meta-analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:2 Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Humans; Liver Function Tests; Network Meta-Analysis; Phenylpropionates; Pulmonary Arterial Hypertension; Pyridazines; Randomized Controlled Trials as Topic; Walk Test	2022

Trials

3 trial(s) available for bosentan anhydrous and lu 208075

Article	Year
Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest, 2009, Volume: 135, Issue:1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Child; Disease-Free Survival; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes; Transaminases; Treatment Outcome; Young Adult	2009
Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest, 2012, Volume: 141, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bosentan; Child; Double-Blind Method; Endothelin Receptor Antagonists; Ethnicity; Exercise Test; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Phenylpropionates; Prevalence; Prospective Studies; Pulmonary Wedge Pressure; Pyridazines; Sex Factors; Sulfonamides; Thiophenes; Treatment Outcome; United States; Walking; Young Adult	2012
Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil-Bosentan and Sildenafil-Ambrisentan Combination Therapies for Pulmonary Hypertension. Clinical and translational science, 2016, Volume: 9, Issue:1 Topics: Adult; Bosentan; Drug Therapy, Combination; Exercise; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Pyridazines; Sildenafil Citrate; Sulfonamides	2016

Other Studies

58 other study(ies) available for bosentan anhydrous and lu 208075

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Identification of clinically used drugs that activate pregnane X receptors. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Animals; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Interactions; Hep G2 Cells; Hepatocytes; Humans; Pharmaceutical Preparations; Pregnane X Receptor; Rats; Receptors, Steroid; Small Molecule Libraries; Species Specificity; Structure-Activity Relationship; Xenobiotics	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists. Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13 Topics: Animals; Aorta; Endothelin Receptor Antagonists; Molecular Structure; Phenylpropionates; Pyridazines; Pyrimidines; Rabbits; Structure-Activity Relationship	2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. Scandinavian journal of clinical and laboratory investigation, 2008, Volume: 68, Issue:4 Topics: Animals; Bosentan; Cytochrome P-450 Enzyme System; Endothelin Receptor Antagonists; Gene Expression Regulation, Enzymologic; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Immunohistochemistry; Intramolecular Oxidoreductases; Lung; Male; Organ Size; Phenylpropionates; Pulmonary Artery; Pyridazines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides	2008
Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2009, Volume: 7, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Costs and Cost Analysis; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Placebos; Purines; Pyridazines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes; Treatment Outcome	2009
Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease. British journal of haematology, 2009, Volume: 147, Issue:5 Topics: Adult; Anemia, Sickle Cell; Antihypertensive Agents; Bosentan; Cardiac Catheterization; Drug Evaluation; Drug Therapy, Combination; Endothelin Receptor Antagonists; Exercise Test; Humans; Hypertension, Pulmonary; Middle Aged; Phenylpropionates; Piperazines; Purines; Pyridazines; Retrospective Studies; Sildenafil Citrate; Sulfonamides; Sulfones; Treatment Outcome	2009
[Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. Revue des maladies respiratoires, 2010, Volume: 27, Issue:2 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Europe; Evidence-Based Medicine; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Practice Guidelines as Topic; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. Applied health economics and health policy, 2010, Volume: 8, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bosentan; Canada; Cost Control; Drug Costs; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Piperazines; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Thiophenes	2010
Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:6 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Bosentan; Cell Culture Techniques; Cells, Cultured; Endothelin Receptor Antagonists; Enkephalin, D-Penicillamine (2,5)-; Estradiol; Female; Hepatocytes; Humans; Isoxazoles; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenylpropionates; Pyridazines; Pyrimidines; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes; Young Adult	2010
Survival after the initiation of combination therapy in patients with pulmonary arterial hypertension: an Australian collaborative report. Internal medicine journal, 2011, Volume: 41, Issue:3 Topics: Adult; Aged; Australia; Bosentan; Cooperative Behavior; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Piperazines; Prospective Studies; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Survival Rate; Young Adult	2011
Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro. European journal of pharmacology, 2011, Jun-25, Volume: 660, Issue:2-3 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bosentan; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Endothelin A Receptor Antagonists; Enzymes; Gene Expression Regulation, Enzymologic; Humans; Inactivation, Metabolic; Pharmaceutical Preparations; Phenylpropionates; Pyridazines; Sulfonamides	2011
Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice. Arthritis research & therapy, 2011, Jun-20, Volume: 13, Issue:3 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Bosentan; Disease Models, Animal; Edema; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Nociception; Phenylpropionates; Pyridazines; Secondary Prevention; Sulfonamides	2011
[Treatment of idiopathic pulmonary arterial hypertension]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2011, Jul-01, Volume: 131, Issue:13-14 Topics: Adult; Airway Resistance; Antihypertensive Agents; Bosentan; Epoprostenol; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Iloprost; Lung Transplantation; Lung Volume Measurements; Male; Middle Aged; Oxygen Consumption; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Treatment Outcome; Vasodilator Agents	2011
Adult congenital heart disease and pulmonary arterial hypertension: the Texas Adult Congenital Heart Program experience. Postgraduate medicine, 2011, Volume: 123, Issue:6 Topics: Adult; Algorithms; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Epoprostenol; Familial Primary Pulmonary Hypertension; Heart Defects, Congenital; Hospitals, Pediatric; Humans; Hypertension, Pulmonary; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Prevalence; Pyridazines; Sulfonamides; Texas; Transition to Adult Care	2011
Clinical safety, pharmacokinetics, and efficacy of ambrisentan therapy in children with pulmonary arterial hypertension. Pediatric pulmonology, 2013, Volume: 48, Issue:1 Topics: Adolescent; Antihypertensive Agents; Bosentan; Child; Child, Preschool; Cohort Studies; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Male; Phenylpropionates; Pyridazines; Retrospective Studies; Sulfonamides	2013
Hemodynamic stability after transitioning between endothelin receptor antagonists in patients with pulmonary arterial hypertension. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Administration, Oral; Aged; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Middle Aged; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Retrospective Studies; Sulfonamides; Thiophenes; Treatment Outcome; Vascular Resistance	2013
Safety and efficacy evaluation of ambrisentan in pulmonary hypertension. Expert opinion on drug safety, 2012, Volume: 11, Issue:6 Topics: Animals; Antihypertensive Agents; Bosentan; Disease Progression; Drug Interactions; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Phenylpropionates; Pyridazines; Receptor, Endothelin B; Sulfonamides	2012
Transitioning between endothelin receptor blockers: monitoring to ensure a smooth transition. The Canadian journal of cardiology, 2013, Volume: 29, Issue:6 Topics: Bosentan; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pulmonary Wedge Pressure; Pyridazines; Sulfonamides; Thiophenes; Vascular Resistance	2013
Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. PloS one, 2012, Volume: 7, Issue:10 Topics: Animals; Bosentan; Calcium; CHO Cells; Clinical Trials, Phase III as Topic; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Inositol Phosphates; Myocytes, Smooth Muscle; Phenylpropionates; Pulmonary Artery; Pyridazines; Pyrimidines; Receptors, Endothelin; Sulfonamides	2012
Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells. Biochemical pharmacology, 2013, Jan-15, Volume: 85, Issue:2 Topics: Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bosentan; Carbolines; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Interactions; Endothelin A Receptor Antagonists; Gene Expression Regulation; Genes, Reporter; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Peroxisome-Targeting Signal 1 Receptor; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Piperazines; Pregnane X Receptor; Promoter Regions, Genetic; Purines; Pyridazines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Proteins; RNA, Messenger; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil	2013
Oral vasodilator therapy in patients with moderate to severe portopulmonary hypertension as a bridge to liver transplantation. European journal of gastroenterology & hepatology, 2013, Volume: 25, Issue:4 Topics: Administration, Oral; Adult; Antihypertensive Agents; Bosentan; Combined Modality Therapy; Exercise Test; Female; Humans; Hypertension, Portal; Hypertension, Pulmonary; Liver Transplantation; Male; Middle Aged; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Pyridazines; Sulfonamides; Vasodilator Agents	2013
Inflammatory responses of airway smooth muscle cells and effects of endothelin receptor antagonism. American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:1 Topics: Airway Remodeling; Bosentan; Chemokines; Endothelin Receptor Antagonists; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypertension, Pulmonary; Inflammation; Matrix Metalloproteinase 13; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Phenylpropionates; Pulmonary Disease, Chronic Obstructive; Pyridazines; Receptors, Endothelin; RNA Stability; RNA, Messenger; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha	2013
Endothelin receptor antagonists attenuate the inflammatory response of human pulmonary vascular smooth muscle cells to bacterial endotoxin. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:2 Topics: Anti-Inflammatory Agents; Bosentan; Cells, Cultured; Cytokines; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Humans; Inflammation; Interleukin-8; Lipopolysaccharide Receptors; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oligopeptides; Phenylpropionates; Piperidines; Pulmonary Artery; Pyridazines; RNA, Messenger; Salmonella; Sulfonamides	2013
Idiopathic pulmonary arterial hypertension. Seminars in respiratory and critical care medicine, 2013, Volume: 34, Issue:5 Topics: Aminorex; Antihypertensive Agents; Appetite Depressants; Bosentan; Dasatinib; Epoprostenol; Familial Primary Pulmonary Hypertension; Fenfluramine; Genetic Predisposition to Disease; Humans; Hypertension, Pulmonary; Iloprost; Phenylpropionates; Piperazines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridazines; Pyrimidines; Risk Factors; Sildenafil Citrate; Sulfonamides; Sulfones; Thiazoles; Vasodilator Agents	2013
Pulmonary hypertension complicating connective tissue disease. Seminars in respiratory and critical care medicine, 2013, Volume: 34, Issue:5 Topics: Antihypertensive Agents; Bosentan; Connective Tissue Diseases; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Lung Diseases, Interstitial; Lung Transplantation; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Prognosis; Pyridazines; Scleroderma, Systemic; Sulfonamides	2013
Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension. Journal of pharmaceutical and biomedical analysis, 2014, Volume: 89 Topics: Bosentan; Carbolines; Child; Child, Preschool; Chromatography, Liquid; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Infant; Male; Phenylpropionates; Piperazines; Purines; Pyridazines; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Tandem Mass Spectrometry	2014
Bladder endothelin-1 receptor binding of bosentan and ambrisentan. Journal of pharmacological sciences, 2014, Volume: 124, Issue:1 Topics: Animals; Antihypertensive Agents; Binding Sites; Bosentan; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin-1; Male; Phenylpropionates; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfonamides; Urinary Bladder	2014
Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes. PloS one, 2014, Volume: 9, Issue:1 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Bile Acids and Salts; Bosentan; Endothelin Receptor Antagonists; Female; Hepatocytes; Humans; Isoxazoles; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Phenylpropionates; Pyridazines; Pyrimidines; Receptors, Endothelin; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides; Symporters; Taurocholic Acid; Thiophenes	2014
Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:3 Topics: Animals; Bosentan; Cerebral Cortex; Dioxoles; Endothelin A Receptor Antagonists; Endothelin-1; Kidney; Lung; Male; Myocardium; Phenylpropionates; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfonamides; Urinary Bladder	2014
Autoimmune hepatitis in a patient with pulmonary arterial hypertension treated with endothelin receptor antagonists. Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:7 Topics: Biopsy; Bosentan; Diagnosis, Differential; Drug Therapy, Combination; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Hepatitis, Autoimmune; Humans; Middle Aged; Phenylpropionates; Pyridazines; Sulfonamides; Tomography, X-Ray Computed; Ultrasonography, Doppler, Duplex	2014
Clinical and molecular study of 4 cases of pulmonary hypertension associated with sarcoidosis. Archivos de bronconeumologia, 2015, Volume: 51, Issue:4 Topics: Bone Morphogenetic Protein Receptors, Type II; Bosentan; Disease Progression; Epoprostenol; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Kv1.5 Potassium Channel; Male; Middle Aged; Mutation; Phenylpropionates; Point Mutation; Pyridazines; Respiratory Function Tests; RNA, Messenger; Sarcoidosis; Sildenafil Citrate; Sulfonamides; Tadalafil; Treatment Outcome	2015
Lack of a clinically significant interaction of grapefruit juice with ambrisentan and bosentan in healthy adults. International journal of clinical pharmacology and therapeutics, 2014, Volume: 52, Issue:11 Topics: Adult; Bosentan; Citrus paradisi; Female; Food-Drug Interactions; Fruit and Vegetable Juices; Humans; Male; Phenylpropionates; Pyridazines; Sulfonamides	2014
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists. The Journal of pharmacology and experimental therapeutics, 2015, Volume: 352, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Epithelial Cells; Hepatocytes; Humans; Isoxazoles; Mitochondria; Molecular Structure; Oxygen Consumption; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes	2015
Desmethyl bosentan displays a similar in vitro interaction profile as bosentan. Pulmonary pharmacology & therapeutics, 2015, Volume: 30 Topics: Animals; Bosentan; Cell Line; Drug Interactions; Endothelin Receptor Antagonists; HEK293 Cells; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Protein 2; Phenylpropionates; Pyridazines; Sulfonamides; Swine	2015
Medical treatment for an adult patient with eisenmenger syndrome. A case report. International heart journal, 2015, Volume: 56 Suppl Topics: Adult; Antihypertensive Agents; Bosentan; Down Syndrome; Eisenmenger Complex; Endothelin Receptor Antagonists; Heart Septal Defects, Ventricular; Humans; Hypertension, Pulmonary; Male; Phenylpropionates; Pyridazines; Sulfonamides	2015
Endothelin receptor B protects granulocyte macrophage colony-stimulating factor mRNA from degradation. The Journal of pharmacology and experimental therapeutics, 2015, Volume: 353, Issue:3 Topics: Antihypertensive Agents; Bosentan; Cells, Cultured; Chemokine CXCL2; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Matrix Metalloproteinase 12; Muscle, Smooth; Oligopeptides; Phenylpropionates; Piperidines; Pyridazines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha	2015
Dual phosphodiesterase type 5 inhibitor therapy for refractory pulmonary arterial hypertension: a pilot study. BMC pulmonary medicine, 2015, May-14, Volume: 15 Topics: Adult; Antihypertensive Agents; Bosentan; Cardiac Catheterization; Drug Therapy, Combination; Endothelin Receptor Antagonists; Epoprostenol; Exercise Test; Female; Humans; Hypertension, Pulmonary; Middle Aged; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Pilot Projects; Prostaglandins; Pulmonary Wedge Pressure; Pyridazines; Retrospective Studies; Sildenafil Citrate; Sulfonamides; Tadalafil; Treatment Outcome; Vascular Resistance; Young Adult	2015
Secure Combination Therapy With Low-Dose Bosentan and Ambrisentan to Treat Portopulmonary Hypertension Minimizing Each Adverse Effect. International heart journal, 2015, Volume: 56, Issue:4 Topics: Antihypertensive Agents; Bosentan; Combined Modality Therapy; Diagnosis, Differential; Dose-Response Relationship, Drug; Echocardiography; Hemodynamics; Humans; Hypertension, Portal; Hypertension, Pulmonary; Liver Cirrhosis; Male; Middle Aged; Phenylpropionates; Pyridazines; Sulfonamides; Treatment Outcome	2015
Use of Pulmonary Hypertension Medications in Patients with Tetralogy of Fallot with Pulmonary Atresia and Multiple Aortopulmonary Collaterals. Pediatric cardiology, 2016, Volume: 37, Issue:2 Topics: Abnormalities, Multiple; Adolescent; Antihypertensive Agents; Bosentan; Catheterization; Child; Child, Preschool; District of Columbia; Echocardiography; Female; Hemodynamics; Hospitals, Pediatric; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Lung; Male; Phenylpropionates; Pulmonary Artery; Pulmonary Atresia; Pyridazines; Retrospective Studies; Sildenafil Citrate; Sulfonamides; Tertiary Care Centers; Tetralogy of Fallot; Young Adult	2016
Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension. Analytical chemistry, 2015, Dec-15, Volume: 87, Issue:24 Topics: Bosentan; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Hypertension, Pulmonary; Limit of Detection; Phenylpropionates; Pyridazines; Reproducibility of Results; Sildenafil Citrate; Sulfonamides; Tadalafil; Tandem Mass Spectrometry	2015
First data from Latvian chronic thromboembolic pulmonary hypertension registry. European journal of internal medicine, 2016, Volume: 32 Topics: Adult; Age Distribution; Aged; Anticoagulants; Bosentan; Chronic Disease; Female; Humans; Hypertension, Pulmonary; Incidence; Latvia; Male; Middle Aged; Phenylpropionates; Prevalence; Pulmonary Embolism; Pyrazoles; Pyridazines; Pyridones; Registries; Rivaroxaban; Sex Distribution; Sildenafil Citrate; Sulfonamides; Vasodilator Agents; Warfarin; Young Adult	2016
Initial dual oral combination therapy in pulmonary arterial hypertension. The European respiratory journal, 2016, Volume: 47, Issue:6 Topics: Adult; Aged; Antihypertensive Agents; Bosentan; Diethylpropion; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Middle Aged; Patient Safety; Phenylpropionates; Pyridazines; Retrospective Studies; Severity of Illness Index; Sildenafil Citrate; Sulfonamides; Tadalafil; Time Factors; Treatment Outcome	2016
Endothelin receptor blockers reduce shunting and angiogenesis in cirrhotic rats. European journal of clinical investigation, 2016, Volume: 46, Issue:6 Topics: Animals; Bosentan; Collateral Circulation; Cyclooxygenase 2; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Hypertension, Portal; Liver Cirrhosis; Male; Neovascularization, Pathologic; Nitric Oxide Synthase Type II; Phenylpropionates; Phosphoproteins; Portal Pressure; Proto-Oncogene Proteins c-akt; Pyridazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2016
Simultaneous Determination of Bosentan, Glimepiride, HYBOS and M1 in Rat Plasma by UPLC-MS-MS and its Application to Pharmacokinetic Study. Journal of chromatographic science, 2016, Volume: 54, Issue:7 Topics: Administration, Oral; Animals; Bosentan; Chromatography, High Pressure Liquid; Hydroxylation; Male; Observer Variation; Phenylpropionates; Protein Denaturation; Pyridazines; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Sulfonylurea Compounds; Tandem Mass Spectrometry	2016
Functional estimation of endothelin-1 receptor antagonism by bosentan, macitentan and ambrisentan in human pulmonary and radial arteries in vitro. European journal of pharmacology, 2017, Jun-05, Volume: 804 Topics: Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Phenylpropionates; Pulmonary Artery; Pyridazines; Pyrimidines; Radial Artery; Receptor, Endothelin A; Sulfonamides; Tissue Survival; Vasoconstriction	2017
Plasma Drug Concentrations in Patients with Pulmonary Arterial Hypertension on Combination Treatment. Respiration; international review of thoracic diseases, 2017, Volume: 94, Issue:1 Topics: Adult; Aged; Bosentan; Case-Control Studies; Drug Interactions; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Pyridazines; Pyrimidines; Sildenafil Citrate; Sulfonamides; Tadalafil	2017
German Guideline for Idiopathic Pulmonary Fibrosis - Update on Pharmacological Therapies 2017. Pneumologie (Stuttgart, Germany), 2018, Volume: 72, Issue:2 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Antacids; Bosentan; Clinical Trials as Topic; Evidence-Based Medicine; Female; Gastroesophageal Reflux; Guideline Adherence; Humans; Idiopathic Pulmonary Fibrosis; Imatinib Mesylate; Indoles; Male; Middle Aged; Phenylpropionates; Pyridazines; Pyridones; Pyrimidines; Sildenafil Citrate; Sulfonamides	2018
Safety and feasibility audit of a home-based drug-transitioning approach for patients with pulmonary arterial hypertension: an observational study. European journal of cardiovascular nursing, 2018, Volume: 17, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Pyridazines; Pyrimidines; Retrospective Studies; Sulfonamides; Treatment Outcome	2018
Transition from Ambrisentan to Bosentan in Pulmonary Arterial Hypertension: A Single-Center Prospective Study. Canadian respiratory journal, 2018, Volume: 2018 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bosentan; Cardiac Catheterization; Drug Substitution; Echocardiography; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Prospective Studies; Pyridazines; Walk Test; Young Adult	2018
Choice of Initial Oral Therapy for Pulmonary Arterial Hypertension: Age and Long-Term Survival. American journal of respiratory and critical care medicine, 2018, 10-15, Volume: 198, Issue:8 Topics: Administration, Oral; Age Factors; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Pyridazines; Pyrimidines; Retrospective Studies; Sildenafil Citrate; Sulfonamides; Tadalafil	2018
The Key Laboratory of Pulmonary Vascular Medicine, Chinese Academy of Medical Sciences (KLPVM-CAMS). European heart journal, 2019, 12-21, Volume: 40, Issue:48 Topics: Academies and Institutes; Administration, Inhalation; Angioplasty, Balloon; Antihypertensive Agents; Asian People; Bone Morphogenetic Protein Receptors, Type II; Bosentan; Calcium Channel Blockers; Cardiology; Cooperative Behavior; Endothelin Receptor Antagonists; Female; Growth Differentiation Factor 2; Guidelines as Topic; Humans; Iloprost; Mutation; Phenylpropionates; Pulmonary Arterial Hypertension; Pulmonary Embolism; Pulmonary Medicine; Pyridazines; Takayasu Arteritis; Vasodilator Agents	2019
Chronic lung disease-associated PH: PAH-approved drugs and established universal healthcare insurance in Japan. Respiratory investigation, 2020, Volume: 58, Issue:4 Topics: Bosentan; Humans; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Insurance Coverage; Japan; Phenylpropionates; Prevalence; Prognosis; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Pyridazines; Pyrimidines; Sildenafil Citrate; Sulfonamides; Treatment Outcome; Universal Health Insurance	2020
Comparison of the protective effects of selective endothelin-a receptor antagonist, ambrisentan, and dual endothelin-A/B receptor antagonist, bosentan, in experimental renal ischemia reperfusion injury. Bratislavske lekarske listy, 2020, Volume: 121, Issue:8 Topics: Animals; Bosentan; Endothelin Receptor Antagonists; Endothelins; Female; Phenylpropionates; Pyridazines; Rats; Receptor, Endothelin A; Reperfusion Injury; Sulfonamides	2020
The Clinical Efficacy of Endothelin Receptor Antagonists in Patients with Pulmonary Arterial Hypertension. International heart journal, 2020, Volume: 61, Issue:4 Topics: Administration, Oral; Adult; Aged; Bosentan; Case-Control Studies; Endothelin Receptor Antagonists; Female; Hemodynamics; Humans; Japan; Male; Middle Aged; Phenylpropionates; Phosphodiesterase 5 Inhibitors; Placebos; Prostaglandins I; Pulmonary Arterial Hypertension; Pulmonary Wedge Pressure; Pyridazines; Pyrimidines; Retrospective Studies; Sulfonamides; Treatment Outcome; Vascular Resistance	2020
Pharmacological counseling in hepatotoxicity induced by macitentan and selexipag: a case report. Journal of medical case reports, 2022, Oct-18, Volume: 16, Issue:1 Topics: Bosentan; Counseling; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Middle Aged; Pulmonary Arterial Hypertension; Receptors, Epoprostenol; Transaminases	2022
Prescribing of endothelin receptor antagonists and riociguat in women of childbearing age in a large German claims database study. Reproductive toxicology (Elmsford, N.Y.), 2023, Volume: 119 Topics: Animals; Bosentan; Cross-Sectional Studies; Endothelin Receptor Antagonists; Female; Hypertension, Pulmonary	2023