Compounds > bosentan anhydrous
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bosentan anhydrous and bq 123

bosentan anhydrous has been researched along with bq 123 in 79 studies

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's34 (43.04)18.2507
2000's34 (43.04)29.6817
2010's11 (13.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ1
Binkert, C; Bolli, MH; Boss, C; Buchmann, S; Bur, D; Clozel, M; Fischli, W; Hess, P; Iglarz, M; Meyer, S; Rein, J; Rey, M; Treiber, A; Weller, T1
Cruciani, G; Goracci, L; Lepri, S; Valeri, A1
Featherstone, RL; Uhlig, S; von Bethmann, AN; Wendel, A1
Lal, H; Williams, KI; Woodward, B1
Baylis, C; Qiu, C; Samsell, L1
Hino, A; Johns, LM; Kim, CJ; Macdonald, RL; Thisted, RA; Weir, BK1
Clozel, M; Hogie, M; Löffler, BM; Richard, V; Thuillez, C2
Rockey, DC1
Brain, SD; Lawrence, E1
Clozel, JP; Clozel, M; Hess, P; Véniant, M1
Lüscher, TF; Oemar, BS; Seo, B; Siebenmann, R; von Segesser, L1
Bauer, C; Diekmann, F; Distler, A; Gretz, N; Hocher, B; Koppenhagen, K; Rohmeiss, P; Schiller, S; Vogt, V; Zart, R1
Breu, V; Clozel, JP; Clozel, M; Dagassan, PH; Kiowski, W; Künzli, A; Turina, M; Vogt, P1
Götz, KH; Hamann, M; Krämer, BK; Kurtz, A; Scholz, H1
Bauer, C; Diekmann, F; Distler, A; Fakhury, M; Gretz, N; Hocher, B; Koppenhagen, K; Metz, D; Neumayer, HH; Rohmeiss, P; Vogt, V; Zart, R1
Franco-Cereceda, A; Holm, P1
Gater, PR; Renzetti, LM; Wasserman, MA1
van den Buuse, M; Webber, KM1
Doucet, J; Gonzalez, W; Michel, JB1
Becker, K; Brodde, OE; Erdbrügger, W; Heinroth-Hoffmann, I; Michel, MC1
Bugge, E; Ytrehus, K1
Leskinen, H; Ruskoaho, H; Vuolteenaho, O1
Wesson, DE1
Bornkessel, B1
Akima, T; Hanada, K; Kawai, N; Nishikibe, M; Ohta, H; Suzuki, J1
Cheng, XM; Flynn, MA; Haleen, SJ; Reynolds, EE; Welch, KM1
Higuchi, H; Hirokawa, M; Hokari, R; Ishii, H; Kimura, H; Miura, S; Nakatsumi, RC; Saito, H; Serizawa, H; Shigematsu, T; Tsuzuki, Y1
D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Tonussi, CR1
Bell, PR; London, NJ; Masood, I; Olojugba, DH; Pemberton, M; Porter, KE1
D'Orléans-Juste, P; De-Melo, JD; Rae, GA; Tonussi, CR1
Keiser, HR; Oriji, GK1
Anadol, AZ; Bayram, O; Dursun, A; Ercan, S1
Colucci, WS; Sam, F1
Horowitz, JD; Oliver, JR; Zhang, Y2
Henriques, MM; Rae, GA; Sampaio, AL1
Nguyen, TD; Thorin, E; Véquaud, P1
Lau, WA; Pennefather, JN; Salamoussa, A; Ventura, S1
Hill, BJ; Katwa, LC; Sturek, M; Wamhoff, BR1
Chen, YF; Oparil, S1
Brodde, OE; Dhein, S; Giessler, C; Silber, RE; Wangemann, T; Zerkowski, HR1
Blandin, V; Breittmayer, JP; Frelin, C; Vigne, P1
Anderson, TJ; Dumont, AS; Kidd, W; Kieser, TM; Lovren, F; Maitland, A; Mather, KJ; McNeill, JH; Stewart, DJ; Triggle, CR; Verma, S1
Abraham, WT; Lamba, S; Suresh, DP1
Anderson, TJ; Dumont, AS; Lovren, F; McNeill, JH; Sutherland, GR; Triggle, CR; Verma, S1
Anderson, TJ; Dumont, AS; McNeill, JH; Stewart, DJ; Verma, S; Yao, L1
Lüscher, TF; Noll, G; Ruschitzka, FT; Spieker, LE1
Ishiguro, S; Kawase, J; Miyamoto, A; Nakamura, Y; Nishio, A1
Baylis, C; Harvey, J; Riggleman, A1
Barton, M; Glodny, B1
Bertel, O; Brunner-Larocca, HP; Kiowski, W; Oechslin, E; Schalcher, C; Suetsch, G1
Anderson, TJ; Badiwala, M; Dumont, AS; Fedak, PW; Ko, L; Lovren, F; Maitland, A; Rao, V; Triggle, CR; Verma, S1
Fedak, PW; Ko, L; Li, RK; Li, SH; Maitland, A; Mickle, DA; Pomroy, NC; Rao, V; Verma, S; Weisel, RD1
Bardou, M; Dumas, JP; Dumas, M; Goirand, F; Guerard, P; Rochette, L1
Mäkinen, M; Piuhola, J; Ruskoaho, H; Szokodi, I1
Lüscher, TF; Spieker, LE1
Bell, SP; Chen, Z; LeWinter, MM; Noguchi, T; Nyland, L1
Capuano, V; Coulombe, A; Deroubaix, E; Ferron, L; Renaud, JF; Ruchon, Y1
D'Orléans-Juste, P; Frighetto, M; Henriques, MG; Piovezan, AP; Rae, GA; Souza, GE1
Goto, K1
Fujimori, A; Miyata, K; Noguchi, Y; Ohtake, A; Sasamata, M; Sato, S; Sudoh, K; Ukai, M; Yuyama, H1
Teerlink, JR1
Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR1
Brás-Silva, C; Correia-Pinto, J; Faria, B; Henriques-Coelho, T; Leite-Moreira, AF; Lourenço, AP; Roncon-Albuquerque, R; Wieland, J1
Berger, Y; Bernasconi, CC; Juillerat-Jeanneret, L1
Cohen, H; Frishman, L; Harats, D; Peled, M; Shaish, A; Tal, R1
Barja-Fidalgo, C; Conte, Fde P; Cunha, FQ; Henriques, Md; Penido, C; Rae, GA; Verri, WA1
Dhalla, NS; Rehsia, NS1
Chen, P; Chen, Y; Droma, Y; Hanaoka, M; Kubo, K; Voelkel, NF1
Bengtsson, M; Kalani, M; Papadogeorgos, NO1
Cavasin, MA; Chapo, J; Peng, Y; Pitts, K; Plato, CF; Sandoval, J; Semus, H1
Chen, P; Chen, Y; Keishi, K; Masayuki, H; Peng, H; Yunden, D1
Atilla, P; Bolay, H; Cakar, AN; Dalkara, T; Emre-Aydıngöz, S; Erdem, SR; Tuncer, M1
Goraca, A; Kleniewska, P; Kolodziejczyk, M; Kowalczyk, A; Skibska, B1
Andrade, EL; Forner, S; Martini, AC; Rae, GA1
Bağrıaçık, EÜ; Dileköz, E; Ercan, S; Karaca, EE; Kul, O; Or, M; Öztürk Fincan, GS; Uzun, F1
Bernard, FC; Dixon, JB; Doan, TN; McKinney, JM; Willett, NJ1

Reviews

10 review(s) available for bosentan anhydrous and bq 123

ArticleYear
[Endothelial receptor antagonists].
    Medizinische Monatsschrift fur Pharmazeuten, 1997, Volume: 20, Issue:7

    Topics: Animals; Antihypertensive Agents; Bosentan; Cardiovascular Diseases; Endothelin Receptor Antagonists; Humans; Peptides, Cyclic; Receptors, Endothelin; Sulfonamides

1997
Endothelin-1 in heart failure: does it play a role?
    Cardiologia (Rome, Italy), 1998, Volume: 43, Issue:9

    Topics: Animals; Bosentan; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Heart Failure; Hemodynamics; Humans; Mice; Myocardial Infarction; Myocardium; Peptides, Cyclic; Rats; Receptors, Endothelin; Stroke Volume; Sulfonamides; Time Factors

1998
Endothelial dysfunction in the pulmonary vascular bed.
    The American journal of the medical sciences, 2000, Volume: 320, Issue:4

    Topics: Animals; Antihypertensive Agents; Atrasentan; Bosentan; Controlled Clinical Trials as Topic; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Epoprostenol; Heart Failure; Humans; Hypertension, Pulmonary; Hypoxia; Lung Diseases, Obstructive; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Circulation; Pyrrolidines; Receptors, Endothelin; RNA, Messenger; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation

2000
New developments in heart failure: role of endothelin and the use of endothelin receptor antagonists.
    Journal of cardiac failure, 2000, Volume: 6, Issue:4

    Topics: Bosentan; Carboxylic Acids; Chronic Disease; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Humans; Indans; Peptides, Cyclic; Prognosis; Pyridines; Pyrimidines; Receptors, Endothelin; Sulfonamides; Treatment Outcome

2000
Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:6

    Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Forecasting; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Myocardial Contraction; Peptides, Cyclic; Phenylpropionates; Predictive Value of Tests; Prognosis; Pyrimidines; Sulfonamides; Time Factors; Vascular Resistance; Vasoconstriction; Ventricular Function, Left

2001
Will endothelin receptor antagonists have a role in heart failure?
    The Medical clinics of North America, 2003, Volume: 87, Issue:2

    Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome

2003
[Prospects for endothelin-related drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Animals; Aspartic Acid Endopeptidases; Bosentan; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Hemodynamics; Humans; Metalloendopeptidases; Organophosphonates; Peptides, Cyclic; Quinazolines; Receptors, Endothelin; Sulfonamides; Sulfonylurea Compounds; Tetracyclines; Tetrazoles

2004
Endothelins: pathophysiology and treatment implications in chronic heart failure.
    Current heart failure reports, 2005, Volume: 2, Issue:4

    Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Peptides, Cyclic; Receptors, Endothelin; Sulfonamides; Treatment Outcome; Vasoconstriction

2005
Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure.
    Heart failure reviews, 2010, Volume: 15, Issue:1

    Topics: Angiotensin II; Animals; Antidiuretic Agents; Antihypertensive Agents; Benzazepines; Biomarkers; Bosentan; Catecholamines; Drug Therapy, Combination; Endothelin-1; Heart Failure; Humans; Peptides, Cyclic; Renin-Angiotensin System; Sulfonamides; Sympathetic Nervous System; Tolvaptan; Treatment Outcome; Vasopressins

2010
The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.
    Archivum immunologiae et therapiae experimentalis, 2015, Volume: 63, Issue:1

    Topics: Animals; Bosentan; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Humans; Inflammation; Lipopolysaccharides; NF-kappa B; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Reactive Oxygen Species; Sepsis; Signal Transduction; Sulfonamides; Superoxides; Tetrazoles

2015

Trials

2 trial(s) available for bosentan anhydrous and bq 123

ArticleYear
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004
Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes.
    Vascular health and risk management, 2009, Volume: 5

    Topics: Aged; Angioplasty, Balloon, Coronary; Bosentan; Coronary Artery Disease; Coronary Circulation; Diabetes Mellitus, Type 2; Endothelin A Receptor Antagonists; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Peptides, Cyclic; Receptor, Endothelin A; Stents; Sulfonamides; Treatment Outcome

2009

Other Studies

67 other study(ies) available for bosentan anhydrous and bq 123

ArticleYear
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
    Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17

    Topics: Administration, Oral; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Pyrimidines; Rats; Rats, Inbred Dahl; Sulfonamides

2012
Metabolism study and biological evaluation of bosentan derivatives.
    European journal of medicinal chemistry, 2016, Oct-04, Volume: 121

    Topics: Animals; Bosentan; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP2C9; Endothelin Receptor Antagonists; Models, Molecular; Protein Conformation; Receptors, Endothelin; Sulfonamides

2016
Pharmacologic characterization of endothelin receptor responses in the isolated perfused rat lung.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:5 Pt 1

    Topics: Analysis of Variance; Animals; Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Epoprostenol; Female; In Vitro Techniques; Lung; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Endothelin; Respiratory Mechanics; Sulfonamides; Thromboxanes; Time Factors; Vascular Resistance

1995
Actions of endothelins and sarafotoxin 6c in the rat isolated perfused lung.
    British journal of pharmacology, 1995, Volume: 115, Issue:4

    Topics: Animals; Bosentan; Bronchoconstriction; Coloring Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Evans Blue; In Vitro Techniques; Indomethacin; Lung; Male; Organ Size; Peptides, Cyclic; Perfusion; Pulmonary Wedge Pressure; Rats; Rats, Wistar; Sulfonamides; Vasoconstrictor Agents; Viper Venoms

1995
Actions of endogenous endothelin on glomerular hemodynamics in the rat.
    The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2

    Topics: Animals; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelins; Glomerular Filtration Rate; Hemodynamics; Kidney Glomerulus; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides

1995
Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys.
    Journal of neurosurgery, 1995, Volume: 83, Issue:3

    Topics: Analysis of Variance; Animals; Blood Flow Velocity; Bosentan; Carotid Artery, Internal; Cerebral Angiography; Cerebral Arteries; Double-Blind Method; Drug Administration Schedule; Drug Evaluation, Preclinical; Endothelins; Ischemic Attack, Transient; Macaca fascicularis; Peptides, Cyclic; Prospective Studies; Random Allocation; Subarachnoid Hemorrhage; Sulfonamides; Ultrasonography, Doppler, Transcranial; Vasodilation

1995
In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats.
    Circulation, 1995, Feb-01, Volume: 91, Issue:3

    Topics: Animals; Arginine; Blood Pressure; Bosentan; Endothelins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Peptides, Cyclic; Phenylephrine; Rats; Rats, Wistar; Sulfonamides

1995
Characterization of endothelin receptors mediating rat hepatic stellate cell contraction.
    Biochemical and biophysical research communications, 1995, Feb-15, Volume: 207, Issue:2

    Topics: Animals; Bosentan; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Least-Squares Analysis; Liver; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides; Vasoconstrictor Agents; Viper Venoms

1995
Effect of BQ-123 and Ro 47-0203 (bosentan) on endothelin-induced vasoconstriction in the rat skin.
    European journal of pharmacology, 1994, Jul-21, Volume: 260, Issue:1

    Topics: Animals; Bosentan; Endothelin Receptor Antagonists; Endothelins; Injections, Intradermal; Male; Peptides, Cyclic; Phenylephrine; Rats; Rats, Wistar; Regional Blood Flow; Skin; Sulfonamides; Vasoconstriction; Vasopressins

1994
Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs.
    Life sciences, 1994, Volume: 55, Issue:6

    Topics: Animals; Arginine; Blood Pressure; Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Peptides, Cyclic; Sulfonamides

1994
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.
    Circulation, 1994, Volume: 89, Issue:3

    Topics: Animals; Azepines; Bosentan; Coronary Vessels; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Female; Humans; Indoles; Male; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Swine; Viper Venoms

1994
Distribution of endothelin receptor subtypes in the rat kidney. Renal and haemodynamic effects of the mixed (A/B) endothelin receptor antagonist bosentan.
    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1995, Volume: 33, Issue:8

    Topics: Aging; Animals; Autoradiography; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelins; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Kidney; Male; Peptide Fragments; Peptides, Cyclic; Protein Binding; Rats; Rats, Inbred WKY; Receptors, Endothelin; Renal Circulation; Sodium; Sulfonamides; Urination; Vascular Resistance

1995
[Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats].
    Archives des maladies du coeur et des vaisseaux, 1995, Volume: 88, Issue:8

    Topics: Animals; Arginine; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelins; Male; Nitric Oxide; Nitroarginine; Peptides, Cyclic; Phenylephrine; Rats; Rats, Wistar; Sulfonamides; Vasoconstriction

1995
Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:1

    Topics: Acetylcholine; Adult; Bosentan; Coronary Artery Disease; Endothelin Receptor Antagonists; Humans; Middle Aged; Peptides, Cyclic; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Up-Regulation; Vasoconstrictor Agents; Viper Venoms

1996
Effects of endothelins on renin secretion from rat kidneys.
    Acta physiologica Scandinavica, 1995, Volume: 155, Issue:2

    Topics: Animals; Bosentan; Calcium; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Isoproterenol; Kidney; Male; Peptides, Cyclic; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Renin; Signal Transduction; Sulfonamides; Viper Venoms

1995
Function and expression of endothelin receptor subtypes in the kidneys of spontaneously hypertensive rats.
    Cardiovascular research, 1996, Volume: 31, Issue:4

    Topics: Animals; Autoradiography; Blood Pressure; Blotting, Northern; Bosentan; Endothelin Receptor Antagonists; Glomerular Filtration Rate; Hypertension; In Situ Hybridization; Kidney; Kidney Glomerulus; Male; Muscle, Smooth, Vascular; Peptides, Cyclic; Protein Binding; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Endothelin; Renal Circulation; RNA, Messenger; Sulfonamides; Up-Regulation

1996
Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins.
    The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:2

    Topics: Adult; Aged; Arm; Arteries; Bosentan; Coronary Vessels; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Female; Humans; Isometric Contraction; Male; Nitric Oxide; Peptides, Cyclic; Pulmonary Artery; Receptors, Endothelin; Saphenous Vein; Sulfonamides; Thoracic Arteries; Tissue Distribution; Vasoconstriction; Vasoconstrictor Agents; Veins; Viper Venoms

1996
Effects of Ro 47-0203 on endothelin-1 and sarafotoxin S6c-induced contractions of human bronchus and guinea-pig trachea.
    European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3

    Topics: Adult; Aged; Animals; Bosentan; Bronchi; Drug Interactions; Endothelin-1; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Endothelin; Sulfonamides; Trachea; Viper Venoms

1996
Intrastriatal injection of endothelin evokes dopaminergic turning behaviour in rats through activation of the ETB receptor.
    Brain research, 1996, Jun-17, Volume: 724, Issue:2

    Topics: Animals; Bosentan; Dopamine; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Injections; Male; Neostriatum; Oligopeptides; Oxidopamine; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Stereotyped Behavior; Sulfonamides; Sympatholytics

1996
Endothelin antagonists in salt-dependent hypertension associated with renal insufficiency.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:5

    Topics: Animals; Blood Pressure; Bosentan; Desoxycorticosterone; Endothelins; Glomerular Filtration Rate; Hypertension; Peptides, Cyclic; Rats; Rats, Wistar; Renal Circulation; Renal Insufficiency; Sodium Chloride; Sulfonamides

1996
Endothelin-induced inositol phosphate formation in rat kidney. Studies on receptor subtypes, G-proteins and regulation during ontogenesis.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:5

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Female; GTP-Binding Proteins; Inositol Phosphates; Kidney Cortex; Male; Peptide Fragments; Peptides, Cyclic; Pertussis Toxin; Rats; Rats, Inbred WKY; Receptors, Endothelin; Sulfonamides; Virulence Factors, Bordetella

1996
Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart.
    Cardiovascular research, 1996, Volume: 32, Issue:5

    Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Benzophenanthridines; Bosentan; Coronary Circulation; Decanoic Acids; Endothelin Receptor Antagonists; Endothelins; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Peptides, Cyclic; Perfusion; Phenanthridines; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides

1996
Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release.
    Circulation research, 1997, Volume: 80, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Function, Right; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Volume; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Hormones; Imidazoles; Losartan; Male; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Peptides, Cyclic; Plasma Substitutes; Pressure; Protein Precursors; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles

1997
Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.
    The Journal of clinical investigation, 1997, May-01, Volume: 99, Issue:9

    Topics: Acidosis, Renal Tubular; Ammonium Sulfate; Animals; Bicarbonates; Bosentan; Diet; Endothelin Receptor Antagonists; Endothelin-1; Extracellular Space; Female; Kidney Tubules, Distal; Male; Peptides, Cyclic; Protons; Rats; Rats, Wistar; Sulfonamides

1997
Hemodynamic effect of endothelin antagonists in dogs with myocardial infarction.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Antihypertensive Agents; Bosentan; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Male; Myocardial Infarction; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Renin-Angiotensin System; Structure-Activity Relationship; Sulfonamides

1998
Endothelin B receptors on human endothelial and smooth-muscle cells show equivalent binding pharmacology.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:1

    Topics: Binding, Competitive; Bosentan; Cells, Cultured; Endothelin Receptor Antagonists; Endothelium, Vascular; Humans; Immunohistochemistry; Indicators and Reagents; Muscle, Smooth, Vascular; Oligopeptides; Peptides, Cyclic; Radioligand Assay; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides

1998
Endothelins promote egg albumin-induced intestinal anaphylaxis in rats.
    Gastroenterology, 1998, Volume: 115, Issue:2

    Topics: Albumins; Anaphylaxis; Animals; Bosentan; Cell Line; Chickens; Eggs; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Histamine; Intestinal Mucosa; Intestines; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Sulfonamides

1998
Effects of endothelin-1 on capsaicin-induced nociception in mice.
    European journal of pharmacology, 1998, Jun-12, Volume: 351, Issue:1

    Topics: Analgesia; Animals; Bosentan; Capsaicin; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hindlimb; Hyperalgesia; Male; Mice; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Serotonin; Sulfonamides; Viper Venoms

1998
Endothelin-B receptors mediate intimal hyperplasia in an organ culture of human saphenous vein.
    Journal of vascular surgery, 1998, Volume: 28, Issue:4

    Topics: Bosentan; Endothelin Receptor Antagonists; Humans; Hyperplasia; Oligopeptides; Organ Culture Techniques; Peptides, Cyclic; Piperidines; Receptor, Endothelin B; Receptors, Endothelin; Saphenous Vein; Sulfonamides; Tunica Intima

1998
Articular nociception induced by endothelin-1, carrageenan and LPS in naive and previously inflamed knee-joints in the rat: inhibition by endothelin receptor antagonists.
    Pain, 1998, Volume: 77, Issue:3

    Topics: Animals; Antihypertensive Agents; Arthritis, Reactive; Bosentan; Carrageenan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Excipients; Knee Joint; Lipopolysaccharides; Male; Nociceptors; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Sulfonamides; Vasoconstrictor Agents; Viper Venoms

1998
Role of nitric oxide in cyclosporine A-induced hypertension.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:5

    Topics: Animals; Aorta; Arginine; Blood Pressure; Bosentan; Cyclic GMP; Cyclosporine; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; Immunosuppressive Agents; Male; Nitrates; Nitrites; Olive Oil; Penicillamine; Peptides, Cyclic; Plant Oils; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstriction

1998
Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 59, Issue:4

    Topics: Animals; Bosentan; Dinoprostone; Endothelin Receptor Antagonists; Endothelins; Female; Glycopeptides; Histocytochemistry; Intestinal Mucosa; Intestines; Ischemia; Leukotriene C4; Male; Peptides, Cyclic; Rats; Reperfusion Injury; Sulfonamides

1998
Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist.
    Cardiovascular research, 1998, Volume: 39, Issue:3

    Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Male; Myocardial Contraction; Myocardial Ischemia; Peptides, Cyclic; Perfusion; Rats; Rats, Inbred Strains; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Regional Blood Flow; Sulfonamides; Vasoconstriction; Ventricular Function, Left

1998
Role of endothelins on lymphocyte accumulation in allergic pleurisy.
    Journal of leukocyte biology, 2000, Volume: 67, Issue:2

    Topics: Animals; Bosentan; CD4-Positive T-Lymphocytes; Chemotaxis, Leukocyte; Endothelin Receptor Antagonists; Endothelin-1; Humans; Interferon-gamma; Interleukin-4; Interleukin-5; Ionomycin; Lymphocyte Subsets; Male; Mice; Mice, Inbred C57BL; Monensin; Oligopeptides; Ovalbumin; Peptides, Cyclic; Piperidines; Pleurisy; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Respiratory Hypersensitivity; Sulfonamides; Tetradecanoylphorbol Acetate

2000
Effects of endothelin receptor antagonists and nitric oxide on myogenic tone and alpha-adrenergic-dependent contractions of rabbit resistance arteries.
    Cardiovascular research, 1999, Aug-15, Volume: 43, Issue:3

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Arteries; Nitric Oxide Synthase; Nitroarginine; Oxymetazoline; Peptides, Cyclic; Phenylephrine; Rabbits; Sulfonamides; Vasoconstriction

1999
The contractile effects of endothelins on the smooth muscle of the rat prostate gland.
    European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2

    Topics: Animals; Bosentan; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Prostate; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Vasoconstrictor Agents; Viper Venoms

2000
Enhanced endothelin(A) receptor-mediated calcium mobilization and contraction in organ cultured porcine coronary arteries.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Animals; Antihypertensive Agents; Bosentan; Calcium; Coronary Vessels; Cryopreservation; Endothelin Receptor Antagonists; Endothelin-1; Isometric Contraction; Kinetics; Muscle, Smooth, Vascular; Oligopeptides; Organ Culture Techniques; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Swine; Vasoconstrictor Agents; Viper Venoms

2000
Differential pattern of endothelin-1-induced inotropic effects in right atria and left ventricles of the human heart.
    Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5

    Topics: Analysis of Variance; Antihypertensive Agents; Bosentan; Colforsin; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Atria; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Oligopeptides; Peptides, Cyclic; Piperidines; Sulfonamides

2000
Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid.
    Molecular pharmacology, 2000, Volume: 58, Issue:6

    Topics: Allosteric Regulation; Animals; Aorta; Benzoic Acid; Biological Transport; Bosentan; Bromobenzoates; Calcium; Cells, Cultured; Chromatography, Gel; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Iodine Radioisotopes; Peptides, Cyclic; Rats; Receptor, Endothelin A; Receptors, Endothelin; Recombinant Proteins; Salicylates; Salicylic Acid; Solubility; Sulfonamides; Vasodilation

2000
Endothelin receptor blockade improves endothelial function in human internal mammary arteries.
    Cardiovascular research, 2001, Volume: 49, Issue:1

    Topics: Acetylcholine; Aged; Antihypertensive Agents; Blood Vessel Prosthesis; Bosentan; Coronary Artery Bypass; Culture Techniques; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Humans; Mammary Arteries; Middle Aged; Oligopeptides; Peptides, Cyclic; Piperidines; Sulfonamides; Vasodilation; Vasodilator Agents

2001
Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits.
    Journal of neurosurgery, 2001, Volume: 94, Issue:2

    Topics: Aged; Antihypertensive Agents; Bosentan; Cerebral Revascularization; Culture Techniques; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Oligopeptides; Peptides, Cyclic; Piperidines; Sulfonamides; Vasodilation

2001
Endothelin antagonism uncovers insulin-mediated vasorelaxation in vitro and in vivo.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Bosentan; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hypoxanthines; In Vitro Techniques; Insulin; Male; Norepinephrine; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Time Factors; Vasodilation; Vasodilator Agents

2001
Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Antihypertensive Agents; Bosentan; Bradykinin; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Glycopeptides; Organ Culture Techniques; Peptides, Cyclic; Receptors, Endothelin; Sulfonamides; Vasodilation

2001
Endothelin mediates some of the renal actions of acutely administered angiotensin II.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:1

    Topics: Angiotensin II; Animals; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelins; Kidney; Kidney Function Tests; Male; Peptides, Cyclic; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides

2001
Endothelin receptor blockade and nitric oxide bioactivity.
    Cardiovascular research, 2001, Volume: 52, Issue:1

    Topics: Acetylcholine; Bosentan; Coronary Artery Bypass; Coronary Disease; Endothelin Receptor Antagonists; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Mammary Arteries; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Receptors, Endothelin; Sulfonamides; Vasodilation; Vasodilator Agents

2001
Rationale and perspective of endothelin-1 antagonism in acute heart failure.
    Journal of cardiovascular pharmacology, 2001, Volume: 38 Suppl 2

    Topics: Acute Disease; Animals; Antihypertensive Agents; Bosentan; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Humans; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides

2001
Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins.
    The Annals of thoracic surgery, 2002, Volume: 73, Issue:4

    Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Bosentan; Coronary Artery Bypass; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Humans; In Vitro Techniques; Middle Aged; Nitroprusside; Peptides, Cyclic; Saphenous Vein; Sulfonamides; Vasoconstriction; Vasodilation; Vasodilator Agents

2002
Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism.
    The Journal of thoracic and cardiovascular surgery, 2002, Volume: 123, Issue:6

    Topics: Antihypertensive Agents; Bosentan; Cells, Cultured; Diabetic Angiopathies; Endothelin Receptor Antagonists; Endothelin-1; Humans; Myocardial Reperfusion Injury; Peptides, Cyclic; Sulfonamides

2002
ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels.
    Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:1

    Topics: Animals; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Hypoxia; Indoles; Lung; Male; Maleimides; Nitric Oxide Synthase; Oligopeptides; Peptides, Cyclic; Piperidines; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides; Vasoconstriction

2003
Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bosentan; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; In Vitro Techniques; Male; Mice; Myocardial Contraction; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Tetrazoles

2003
Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:4

    Topics: Amiloride; Animals; Bosentan; Cardiac Output, Low; Echocardiography; Endothelin Receptor Antagonists; Energy Metabolism; Heart Function Tests; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Oxygen Consumption; Peptides, Cyclic; Rats; Rats, Inbred Dahl; Receptor, Endothelin A; Receptor, Endothelin B; Sodium-Hydrogen Exchangers; Sulfonamides

2003
Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.
    Circulation research, 2003, Dec-12, Volume: 93, Issue:12

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Bosentan; Butadienes; Calcium Channels, T-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Constriction, Pathologic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Gene Expression; Losartan; Male; Membrane Potentials; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nickel; Nitriles; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Endothelin; RNA, Messenger; Signal Transduction; Sulfonamides

2003
The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:2

    Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Bosentan; Endothelin Receptor Antagonists; Endothelins; Heart; Hypoxia; Male; Myocardial Ischemia; Peptides, Cyclic; Radioimmunoassay; Rats; Sulfonamides

2004
Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice.
    British journal of pharmacology, 2004, Volume: 141, Issue:4

    Topics: Animals; Antigens; Bosentan; Dose-Response Relationship, Drug; Endothelins; Hyperalgesia; Hypersensitivity; Indicators and Reagents; Male; Mice; Oligopeptides; Ovalbumin; p-Methoxy-N-methylphenethylamine; Pain; Peptides, Cyclic; Piperidines; Sulfonamides; Viper Venoms

2004
Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Administration, Oral; Animals; Atrasentan; Binding, Competitive; Biological Availability; Blood Pressure; Bosentan; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Injections, Intravenous; Muscle, Smooth, Vascular; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrimidines; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Viper Venoms

2004
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold Temperature; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-1; Endothelins; Grooming; Hyperalgesia; Indomethacin; Male; Maxillary Nerve; Nerve Compression Syndromes; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Trigeminal Neuralgia

2006
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4

    Topics: Angiotensinogen; Animals; Antihypertensive Agents; Bosentan; Cytochrome P-450 CYP11B2; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Myocardial Contraction; Natriuretic Peptide, Brain; Neurotransmitter Agents; Peptides, Cyclic; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Ventricular Function; Ventricular Remodeling

2006
Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Alkylating Agents; Antineoplastic Agents; Apoptosis; Bosentan; Cell Line, Tumor; Cell Survival; Dacarbazine; Drug Delivery Systems; Drug Synergism; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Fas Ligand Protein; Genetic Variation; Humans; Melanoma; Membrane Glycoproteins; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin B; RNA, Messenger; Sulfonamides; Tumor Necrosis Factors

2006
Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:5

    Topics: Animals; Aorta; beta-Galactosidase; Bosentan; Cattle; Endothelial Cells; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Luciferases; Lung; Mice; Mice, Transgenic; Oligopeptides; Peptides, Cyclic; Piperidines; RNA, Messenger; Sulfonamides; Tissue Distribution

2006
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.
    Journal of leukocyte biology, 2008, Volume: 84, Issue:3

    Topics: Animals; Antihypertensive Agents; Arthritis; Bosentan; Cell Movement; Chemokine CXCL1; Chemokines; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunologic Factors; Inflammation Mediators; Knee Joint; Leukocytes; Leukotriene B4; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Oligopeptides; Peptides, Cyclic; Piperidines; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Synovial Fluid; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents; Viper Venoms; Zymosan

2008
Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats.
    The European respiratory journal, 2010, Volume: 35, Issue:4

    Topics: Animals; Antihypertensive Agents; Blotting, Western; Bosentan; Caspase 3; Endothelin A Receptor Antagonists; Endothelin-1; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxidative Stress; Peptides, Cyclic; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Smoking; Sulfonamides

2010
Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats.
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:6

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Hemodynamics; Hepatic Stellate Cells; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Oligopeptides; Peptides, Cyclic; Piperidines; Portal Pressure; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Sulfonamides

2010
[The mechanism and pulmonary-protective effects of endothelin-1 receptor antagonist in chronic obstructive pulmonary diseases rat model].
    Zhonghua nei ke za zhi, 2010, Volume: 49, Issue:5

    Topics: Animals; Antihypertensive Agents; Apoptosis; Bosentan; Caspase 3; Endothelin A Receptor Antagonists; Interleukin-1beta; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Peptides, Cyclic; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha

2010
Cyclosporine A-induced acute hepatotoxicity in guinea pigs is associated with endothelin-mediated decrease in local hepatic blood flow.
    Life sciences, 2011, Apr-25, Volume: 88, Issue:17-18

    Topics: Animals; Bosentan; Cyclosporine; Dose-Response Relationship, Drug; Endothelins; Female; Glycerol; Guinea Pigs; Liver; Liver Circulation; Male; Peptides, Cyclic; Sulfonamides

2011
Neuropathic pain induced by spinal cord injury: Role of endothelin ETA and ETB receptors.
    Neuroscience letters, 2016, 03-23, Volume: 617

    Topics: Animals; Bosentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Gray Matter; Hyperalgesia; Male; Motor Activity; Neuralgia; Peptides, Cyclic; Physical Stimulation; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Sulfonamides; Touch; White Matter

2016
The effect of endothelin receptor antagonists in the endotoxin-induced uveitis rabbit model
    Cutaneous and ocular toxicology, 2018, Volume: 37, Issue:2

    Topics: Animals; Aqueous Humor; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Eye; Eye Proteins; Intravitreal Injections; Leukocyte Count; Lipopolysaccharides; Male; Peptides, Cyclic; Rabbits; Sulfonamides; Uveitis

2018
Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat knee.
    Acta biomaterialia, 2019, 07-15, Volume: 93

    Topics: Animals; Biocompatible Materials; Bosentan; Drug Carriers; Drug Liberation; Endothelin-1; Fluorescent Dyes; Injections, Intra-Articular; Kinetics; Knee Joint; Lymphatic Vessels; Male; Optical Imaging; Osteoarthritis; Peptides, Cyclic; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Synovial Fluid; Tissue Distribution

2019