bosentan anhydrous has been researched along with antipyrine in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| McCulloch, J; Patel, TR | 1 |
| Breu, V; Graham, DI; McAuley, MA; McCulloch, J | 1 |
| Blanchard, N; Coassolo, P; Hewitt, NJ; Jones, H; Lavé, T; Silber, P | 1 |
10 other study(ies) available for bosentan anhydrous and antipyrine
| Article | Year |
|---|---|
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Failure of an endothelin antagonist to modify hypoperfusion after transient global ischaemia in the rat.
Topics: Animals; Antipyrine; Autoradiography; Blood Pressure; Bosentan; Brain Ischemia; Carbon Radioisotopes; Carotid Artery Diseases; Cerebrovascular Circulation; Endothelins; Hemorrhage; Hypotension; Male; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors | 1996 |
The effects of bosentan on cerebral blood flow and histopathology following middle cerebral artery occlusion in the rat.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Autoradiography; Bosentan; Brain Ischemia; Carbon Radioisotopes; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Endothelin Receptor Antagonists; Isotope Labeling; Laser-Doppler Flowmetry; Male; Rats; Rats, Sprague-Dawley; Sulfonamides | 1996 |
Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations.
Topics: Antipyrine; Bosentan; Cell Culture Techniques; Cryopreservation; Hepatocytes; Humans; Kinetics; Metabolic Clearance Rate; Models, Biological; Monte Carlo Method; Oxazepam; Pharmaceutical Preparations; Protein Binding; Reproducibility of Results; Serum; Sulfonamides | 2006 |