bosentan anhydrous has been researched along with act-132577 in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Binkert, C; Bolli, MH; Boss, C; Buchmann, S; Bur, D; Clozel, M; Fischli, W; Hess, P; Iglarz, M; Meyer, S; Rein, J; Rey, M; Treiber, A; Weller, T | 1 |
| Bolli, MH; Boss, C; Gatfield, J | 1 |
| Äänismaa, P; de Kanter, R; Delahaye, S; Hess, P; Sidharta, P; Treher, M; Treiber, A | 1 |
| Alessandri, E; Brizzolara, R; Cutolo, M; Montagna, P; Pizzorni, C; Smith, V; Soldano, S; Sulli, A; Tavilla, PP; Villaggio, B | 1 |
1 review(s) available for bosentan anhydrous and act-132577
| Article | Year |
|---|---|
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.
Topics: Bosentan; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pyrimidines; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides | 2016 |
1 trial(s) available for bosentan anhydrous and act-132577
| Article | Year |
|---|---|
Macitentan does not interfere with hepatic bile salt transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bosentan; Cell Line; Cricetinae; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hepatocytes; Humans; Liver; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Pyrimidines; Rats; Sulfonamides; Symporters | 2014 |
2 other study(ies) available for bosentan anhydrous and act-132577
| Article | Year |
|---|---|
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Topics: Administration, Oral; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Pyrimidines; Rats; Rats, Inbred Dahl; Sulfonamides | 2012 |
Effects of macitentan and its active metabolite on cultured human systemic sclerosis and control skin fibroblasts.
Topics: Actins; Aged; Bosentan; Down-Regulation; Endothelin A Receptor Antagonists; Female; Fibroblasts; Humans; Male; Middle Aged; Pyrimidines; Scleroderma, Systemic; Skin; Sulfonamides | 2015 |