bortezomib and naphthalene

bortezomib has been researched along with naphthalene* in 1 studies

Other Studies

1 other study(ies) available for bortezomib and naphthalene

Article	Year
Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors. Bioorganic & medicinal chemistry, 2018, 03-01, Volume: 26, Issue:5 A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed. These PIs bearing 4-aromatic sulfonyl naphthalene-based scaffold and Leu-boronic moiety as covalent bonding group displayed far better activity than PI-8182 for inhibiting ChT-L in preliminary biological activity test. The results showed that 2a (IC Topics: Binding Sites; Boronic Acids; Bortezomib; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; MCF-7 Cells; Microsomes; Molecular Docking Simulation; Naphthalenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Structure-Activity Relationship	2018

Article

Year

Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors.

Bioorganic & medicinal chemistry, 2018, 03-01, Volume: 26, Issue:5

A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed. These PIs bearing 4-aromatic sulfonyl naphthalene-based scaffold and Leu-boronic moiety as covalent bonding group displayed far better activity than PI-8182 for inhibiting ChT-L in preliminary biological activity test. The results showed that 2a (IC

Topics: Binding Sites; Boronic Acids; Bortezomib; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; MCF-7 Cells; Microsomes; Molecular Docking Simulation; Naphthalenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Structure-Activity Relationship

2018