boron and thymosin-beta(4)

Anionic boron clusters are man-made, inorganic compounds with potential applications in therapeutic peptides modification to improve their biological activity and pharmacokinetics, e.g., by enabling complexation with serum albumin. However, the conjugation of anionic boron clusters and peptides remains poorly understood. Here, we report a solid-state, thermal reaction to selectively conjugate carboxylic groups in the peptide thymosin β4 (Tβ4) with cyclic oxonium derivatives of anionic boron clusters (dodecaborate anion [B

Topics: Anions; Boron; Cell Line; Coordination Complexes; Half-Life; Humans; Hydrogen-Ion Concentration; Hydrolysis; Myocytes, Cardiac; Serum Albumin; Thymosin