boron and azulene

boron has been researched along with azulene* in 2 studies

Other Studies

2 other study(ies) available for boron and azulene

Article	Year
Prospecting in Hückel-space: from hinokitiol to non-benzenoid organic electronics. Chemical record (New York, N.Y.), 2014, Volume: 14, Issue:1 Topics: Azulenes; Boron; Cations; Cyclopropanes; Electrons; Quantum Theory; Tropolone	2014
Synthesis of carboranes containing an azulene framework and in vitro evaluation as boron carriers. Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18 3-(o-Carboranylhydroxymethyl)-7-isopropylazulene sodium carboxylate (1) and 3-(o-carboranylmethyl)-7-isopropylazulene sodium sulfonate (2) were synthesized from the palladium-catalyzed addition reaction of 1-carboranyltributylstannane (4) to azulene aldehydes (3 and 9). Although the water solubility of 1 was of the order of 10(-6) M, that of 2 was of the order of 10(-3) M and was enough for clinical use. The cytotoxicity of 1 (IC50) toward B-16 melanoma cells was of the order of 10(-5) M, whereas that of 2 was of the order of 10(-4) M. This value was close to that of BPA (approximately 9 x 10(-3) M) which is utilized for clinical use. The boron uptake by B-16 cells was 0.17 microgram of B/10(6) cells for 1 and 0.25 microgram of B/10(6) cells for 2. It is clear that compound 2 accumulates in B-16 melanoma cells with a significantly high level although it is highly water soluble and its cytotoxicity is significantly low. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azulenes; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Survival; Cycloheptanes; Cyclopentanes; Drug Carriers; Drug Screening Assays, Antitumor; Melanoma, Experimental; Mice	1997

Article

Year

Prospecting in Hückel-space: from hinokitiol to non-benzenoid organic electronics.

Chemical record (New York, N.Y.), 2014, Volume: 14, Issue:1

Topics: Azulenes; Boron; Cations; Cyclopropanes; Electrons; Quantum Theory; Tropolone

2014

Synthesis of carboranes containing an azulene framework and in vitro evaluation as boron carriers.

Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18

3-(o-Carboranylhydroxymethyl)-7-isopropylazulene sodium carboxylate (1) and 3-(o-carboranylmethyl)-7-isopropylazulene sodium sulfonate (2) were synthesized from the palladium-catalyzed addition reaction of 1-carboranyltributylstannane (4) to azulene aldehydes (3 and 9). Although the water solubility of 1 was of the order of 10(-6) M, that of 2 was of the order of 10(-3) M and was enough for clinical use. The cytotoxicity of 1 (IC50) toward B-16 melanoma cells was of the order of 10(-5) M, whereas that of 2 was of the order of 10(-4) M. This value was close to that of BPA (approximately 9 x 10(-3) M) which is utilized for clinical use. The boron uptake by B-16 cells was 0.17 microgram of B/10(6) cells for 1 and 0.25 microgram of B/10(6) cells for 2. It is clear that compound 2 accumulates in B-16 melanoma cells with a significantly high level although it is highly water soluble and its cytotoxicity is significantly low.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azulenes; Boron; Boron Compounds; Boron Neutron Capture Therapy; Cell Survival; Cycloheptanes; Cyclopentanes; Drug Carriers; Drug Screening Assays, Antitumor; Melanoma, Experimental; Mice

1997