boron and arginyl-glycyl-aspartic-acid

boron has been researched along with arginyl-glycyl-aspartic-acid* in 1 studies

Other Studies

1 other study(ies) available for boron and arginyl-glycyl-aspartic-acid

Article	Year
Targeting liposomes to tumor endothelial cells for neutron capture therapy. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2004, Volume: 61, Issue:5 The aim of our work is to target (10)B to the tumor vasculature for neutron capture therapy (NCT). Alpha (v)-integrin specific RGD-peptides were coupled to liposomes that encapsulated dodecahydrododecaborate. These RGD-liposomes strongly associated with human umbilical vein endothelial cells (HUVEC) expressing this integrin and were internalized. Proliferating HUVEC proved sensitive to treatment with gamma-irradiation resulting in decreased cell viability and pronounced inhibition of DNA-synthesis with increasing dose. Irradiation of RGD-(10)B-liposome incubated HUVEC with neutrons strongly inhibited endothelial cell viability. These results suggest that efficient NCT can be achieved by targeting (10)B-liposomes to angiogenic endothelium in tumors. Topics: Boron; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA, Neoplasm; Endothelium, Vascular; Gamma Rays; Humans; Isotopes; Liposomes; Neoplasms; Neovascularization, Pathologic; Oligopeptides	2004

Article

Year

Targeting liposomes to tumor endothelial cells for neutron capture therapy.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2004, Volume: 61, Issue:5

The aim of our work is to target (10)B to the tumor vasculature for neutron capture therapy (NCT). Alpha (v)-integrin specific RGD-peptides were coupled to liposomes that encapsulated dodecahydrododecaborate. These RGD-liposomes strongly associated with human umbilical vein endothelial cells (HUVEC) expressing this integrin and were internalized. Proliferating HUVEC proved sensitive to treatment with gamma-irradiation resulting in decreased cell viability and pronounced inhibition of DNA-synthesis with increasing dose. Irradiation of RGD-(10)B-liposome incubated HUVEC with neutrons strongly inhibited endothelial cell viability. These results suggest that efficient NCT can be achieved by targeting (10)B-liposomes to angiogenic endothelium in tumors.

Topics: Boron; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA, Neoplasm; Endothelium, Vascular; Gamma Rays; Humans; Isotopes; Liposomes; Neoplasms; Neovascularization, Pathologic; Oligopeptides

2004