bombesin--leu(13)-psi-ch2nh-leu(14)- and ranatensin

bombesin--leu(13)-psi-ch2nh-leu(14)- has been researched along with ranatensin* in 1 studies

Other Studies

1 other study(ies) available for bombesin--leu(13)-psi-ch2nh-leu(14)- and ranatensin

Article	Year
Stimulatory effects of bombesin-like peptides on hypothalamic arcuate neurons in rat brain slices. Brain research bulletin, 1994, Volume: 35, Issue:3 The effects of bombesin, gastrin-releasing peptide, neuromedin C, ranatensin, and neuromedin B on hypothalamic arcuate neurons were tested in this study using extracellular single-unit recording in fresh brain tissue slices. Adult ovariectomized Sprague-Dawley rats were used for preparation of brain slices. All bombesin-like peptides in pmol ranges exhibited potent stimulatory effects on the firing of arcuate neurons, i.e., gastrin-releasing peptide stimulated 90.9% (n = 22), bombesin 78.0% (n = 41), neuromedin C 63.2% (n = 19), ranatensin 58.0% (n = 22), and neuromedin B 50.0% (n = 6) of arcuate neurons tested. Pretreatments with either [Leu13-psi(CH2NH)-Leu14]-bombesin or [D-Phe6,Des-Met14]-bombesin6-14 ethylamide, two bombesin antagonists, significantly blocked most of the actions of bombesin-like peptides tested. The present results further support the notion that bombesin-like peptides may play a significant role in the arcuate nucleus. Topics: Animals; Arcuate Nucleus of Hypothalamus; Bombesin; Female; Follow-Up Studies; Gastrin-Releasing Peptide; In Vitro Techniques; Neurokinin B; Neurons; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical	1994

Article

Year

Stimulatory effects of bombesin-like peptides on hypothalamic arcuate neurons in rat brain slices.

Brain research bulletin, 1994, Volume: 35, Issue:3

The effects of bombesin, gastrin-releasing peptide, neuromedin C, ranatensin, and neuromedin B on hypothalamic arcuate neurons were tested in this study using extracellular single-unit recording in fresh brain tissue slices. Adult ovariectomized Sprague-Dawley rats were used for preparation of brain slices. All bombesin-like peptides in pmol ranges exhibited potent stimulatory effects on the firing of arcuate neurons, i.e., gastrin-releasing peptide stimulated 90.9% (n = 22), bombesin 78.0% (n = 41), neuromedin C 63.2% (n = 19), ranatensin 58.0% (n = 22), and neuromedin B 50.0% (n = 6) of arcuate neurons tested. Pretreatments with either [Leu13-psi(CH2NH)-Leu14]-bombesin or [D-Phe6,Des-Met14]-bombesin6-14 ethylamide, two bombesin antagonists, significantly blocked most of the actions of bombesin-like peptides tested. The present results further support the notion that bombesin-like peptides may play a significant role in the arcuate nucleus.

Topics: Animals; Arcuate Nucleus of Hypothalamus; Bombesin; Female; Follow-Up Studies; Gastrin-Releasing Peptide; In Vitro Techniques; Neurokinin B; Neurons; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

1994