boc-tyr(s03)-nle-gly-trp-nle-asp-2-phenylethyl-ester has been researched along with 2-aminoethoxydiphenyl-borate* in 1 studies
1 other study(ies) available for boc-tyr(s03)-nle-gly-trp-nle-asp-2-phenylethyl-ester and 2-aminoethoxydiphenyl-borate
| Article | Year |
|---|---|
Cholecystokinin analog JMV-180-induced intracellular calcium oscillations are mediated by inositol 1,4,5-trisphosphate in rat pancreatic acini.
To investigate whether inositol 1,4,5-trisphosphate (IP3) is involved in secretory response of pancreatic acini to cholecystokinin (CCK) analog Boc-Tyr (SO3H)-Nle-Gly-Trp-Nle-Asp-2-phenylethylester.2NH3 (JMV-180).. Dynamics of cytosolic Ca2+ concentration, [Ca2+]c, was recorded by ratiometry of Fura-2 in pancreatic acini.. In perfused preparations of isolated rat pancreatic acinar cells, 2-aminoethoxydiphenylborate (2APB), a new membrane permeant inhibitory modulator of IP3-mediated calcium release from internal stores, inhibited JMV-180-induced [Ca2+]c spikes, and 2APB at 100 mumol.L-1 resulted in an immediate, complete inhibition of the spikes.. Recurrent [Ca2+]c spikes induced by continuous stimulation with JMV-180 are initiated via IP3-mediated Ca2+ release from internal Ca2+ stores. Topics: Animals; Boron Compounds; Calcium Channels; Calcium Signaling; Cell Separation; Female; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sincalide | 2000 |