Page last updated: 2024-09-03

bmy 42393 and iloprost

bmy 42393 has been researched along with iloprost in 14 studies

Compound Research Comparison

Studies
(bmy 42393)
Trials
(bmy 42393)
Recent Studies (post-2010)
(bmy 42393)
Studies
(iloprost)
Trials
(iloprost)
Recent Studies (post-2010) (iloprost)
21012,150271462

Protein Interaction Comparison

ProteinTaxonomybmy 42393 (IC50)iloprost (IC50)
Prostacyclin receptorHomo sapiens (human)0.0112

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (64.29)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brassard, CL; Buchanan, JO; Federici, ME; Fleming, JS; Gamberdella, M; Meanwell, NA; Rosenfeld, MJ; Trehan, AK; Wright, JJ; Zavoico, GB1
Brassard, CL; Buchanan, JO; Gougoutas, JZ; Malley, MF; Martin, SW; Meanwell, NA; Romine, JL; Rosenfeld, MJ; Trehan, AK; Wright, JJ1
Brassard, CL; Buchanan, JO; Federici, ME; Fleming, JS; Gamberdella, M; Hartl, KS; Meanwell, NA; Rosenfeld, MJ; Wright, JJ; Zavoico, GB1
Hattori, K; Okitsu, O; Tabuchi, S; Taniguchi, K1
Asaki, T; Hamamoto, T; Kuwabara, K; Kuwano, K; Sugiyama, Y1
Asaki, T; Hamamoto, T; Kuwabara, K; Kuwano, K; Niwa, T; Sugiyama, Y1
Meanwell, NA1
Brassard, CL; Buchanan, JO; Federici, ME; Fleming, JS; Gamberdella, M; Hartl, KS; Meanwell, NA; Rosenfeld, MJ; Trehan, AK; Wright, JJ1
Wise, H2
Brassard, CL; Federici, ME; Meanwell, NA; Romine, J; Seiler, SM1
Chan, HW; Ho, JK; Jones, RL; Lam, WL; Qian, YM; Wise, H; Wong, HN; Yim, AP1
Chow, KB; Wise, H1
Chow, KB; Wise, H; Wong, YH1

Other Studies

14 other study(ies) available for bmy 42393 and iloprost

ArticleYear
Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives.
    Journal of medicinal chemistry, 1992, Sep-18, Volume: 35, Issue:19

    Topics: Adenosine Diphosphate; Cell Membrane; Humans; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship

1992
Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.
    Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24

    Topics: Acetates; Adenosine Diphosphate; Binding, Competitive; Crystallization; Epoprostenol; Humans; Hydrogen Bonding; Iloprost; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Epoprostenol; Receptors, Prostaglandin; Structure-Activity Relationship

1993
Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha to the oxazole ring.
    Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24

    Topics: Adenosine Diphosphate; Epoprostenol; Humans; Hydrogen Bonding; Molecular Structure; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Epoprostenol; Receptors, Prostaglandin; Structure-Activity Relationship

1993
A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic.
    Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24

    Topics: Administration, Oral; Animals; Area Under Curve; Epoprostenol; Fasting; Models, Molecular; Molecular Conformation; Oxazoles; Stereoisomerism; Structure-Activity Relationship

2003
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
    Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21

    Topics: Humans; Pyrazines; Receptors, Epoprostenol; Structure-Activity Relationship

2007
Structure-activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists.
    Bioorganic & medicinal chemistry letters, 2007, Dec-01, Volume: 17, Issue:23

    Topics: Heterocyclic Compounds; Humans; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazines; Receptors, Epoprostenol; Structure-Activity Relationship

2007
Synopsis of some recent tactical application of bioisosteres in drug design.
    Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8

    Topics: Cytochrome P-450 Enzyme System; Drug Design

2011
Non-prostanoid prostacyclin mimetics. 6. Derivatives of 2-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid modified beta-to the oxazole ring.
    Drug design and discovery, 1994, Volume: 11, Issue:1

    Topics: Cell Membrane; Humans; Iloprost; Oxazoles; Phenoxyacetates; Platelet Aggregation Inhibitors; Structure-Activity Relationship

1994
The inhibitory effects of non-prostanoid prostacyclin mimetics on rat neutrophil function.
    Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 54, Issue:5

    Topics: Acetates; Animals; Calcium; Cell Aggregation; Cyclic AMP; Drug Design; Epoprostenol; Glyburide; Iloprost; Imidazoles; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phenoxyacetates; Phosphodiesterase Inhibitors; Prostaglandins, Synthetic; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin

1996
[3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding.
    Prostaglandins, 1997, Volume: 53, Issue:1

    Topics: Acetates; Adenylyl Cyclases; Animals; Binding, Competitive; Cell Membrane; Cyclic AMP; Epoprostenol; GTP Phosphohydrolases; Humans; Iloprost; Imidazoles; Oxazoles; Phenoxyacetates; Platelet Aggregation Inhibitors; Protein Kinases; Rabbits; Rats

1997
Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:4

    Topics: Acetates; Aged; Cardiovascular Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Fatty Acids; Humans; Iloprost; Imidazoles; Indoles; Middle Aged; Muscle, Smooth, Vascular; Oxazoles; Phenoxyacetates; Platelet Aggregation Inhibitors; Prostaglandins, Synthetic; Pulmonary Artery; Receptors, Epoprostenol; Receptors, Prostaglandin; Structure-Activity Relationship; Vasoconstrictor Agents; Vasodilator Agents

1997
The effect of prostacyclin mimetics on neutrophil function.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Acetates; Animals; Cell Aggregation; Cyclic AMP; Epoprostenol; Iloprost; Imidazoles; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Peritoneal Cavity; Phenoxyacetates; Pyrrolidinones; Rats; Rolipram; Second Messenger Systems; Sulfonamides

1997
The effect of non-prostanoid prostacyclin mimetics on cyclic AMP production by neuronal SK-N-SH cells.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Acetates; Cell Line; Cyclic AMP; Epoprostenol; Humans; Iloprost; Imidazoles; Kinetics; Neuroblastoma; Neurons; Oxazoles; Phenoxyacetates

1997
Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics.
    British journal of pharmacology, 2001, Volume: 134, Issue:7

    Topics: Acetates; Adenylyl Cyclases; Alprostadil; Animals; Cell Survival; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Iloprost; Imidazoles; Inositol Phosphates; Oxazoles; Phenoxyacetates; Pyridines; Receptors, Epoprostenol; Receptors, Prostaglandin; Transfection; Tritium; Type C Phospholipases

2001