bms345541 and olaparib

bms345541 has been researched along with olaparib* in 1 studies

Other Studies

1 other study(ies) available for bms345541 and olaparib

Article	Year
NF-κB and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells. Molecular cancer research : MCR, 2019, Volume: 17, Issue:3 NF-κB mediates acquired resistance in acute myeloid leukemia (AML) cells treated with DNA-damaging agents. Because DNA repair is the major molecular shift that alters sensitivity to DNA-damaging agents, we explored whether activation of the NF-κB pathway promotes AML cell survival by regulating DNA repair after chemotherapy. Our results showed that RELA, an important subunit of NF-κB, regulated DNA repair by binding to the promoter region of the Topics: Animals; DNA Damage; DNA Repair; Feedback, Physiological; Gene Knockdown Techniques; Heterografts; Humans; Imidazoles; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Promoter Regions, Genetic; Quinoxalines; Transcription Factor RelA	2019

Article

Year

NF-κB and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells.

Molecular cancer research : MCR, 2019, Volume: 17, Issue:3

NF-κB mediates acquired resistance in acute myeloid leukemia (AML) cells treated with DNA-damaging agents. Because DNA repair is the major molecular shift that alters sensitivity to DNA-damaging agents, we explored whether activation of the NF-κB pathway promotes AML cell survival by regulating DNA repair after chemotherapy. Our results showed that RELA, an important subunit of NF-κB, regulated DNA repair by binding to the promoter region of the

Topics: Animals; DNA Damage; DNA Repair; Feedback, Physiological; Gene Knockdown Techniques; Heterografts; Humans; Imidazoles; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Promoter Regions, Genetic; Quinoxalines; Transcription Factor RelA

2019