bms345541 has been researched along with 3-5-bis(2-fluorobenzylidene)piperidin-4-one* in 2 studies
2 other study(ies) available for bms345541 and 3-5-bis(2-fluorobenzylidene)piperidin-4-one
| Article | Year |
|---|---|
Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; Humans; I-kappa B Kinase; Mice, Nude; Molecular Docking Simulation; Neoplasms; NF-kappa B; Phosphorylation; Piperidones; Signal Transduction | 2018 |
Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer.
The nuclear factor-kappa B (NF-κB) signaling pathway has been targeted for the therapy of various cancers, including lung cancer. EF24 was considered as a potent inhibitor of NF-κB signaling pathway. In this study, a series of asymmetric EF24 analogues were synthesized and evaluated for their anti-cancer activity against three lung cancer cell lines (A549, LLC, H1650). Most of the compounds exhibited good anti-tumor activity. Among them, compound 81 showed greater cytotoxicity than EF24. Compound 81 also possessed a potent anti-migration and anti-proliferative ability against A549 cells in a concentration-dependent manner. Moreover, compound 81 induced lung cancer cells death by inhibiting NF-κB signaling pathway, and activated the JNK-mitochondrial apoptotic pathway by increasing reactive oxygen species (ROS) generation resulting in apoptosis. In summary, compound 81 is a valuable candidate for anti-lung cancer therapy. Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Drug Design; Humans; Lung; Lung Neoplasms; Mitochondria; NF-kappa B; Piperidones; Reactive Oxygen Species; Signal Transduction | 2017 |