bms-833923 and cyclopamine

bms-833923 has been researched along with cyclopamine* in 2 studies

Other Studies

2 other study(ies) available for bms-833923 and cyclopamine

Article	Year
Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone. Development (Cambridge, England), 2017, 04-01, Volume: 144, Issue:7 Topics: Animal Fins; Animals; Basement Membrane; Benzamides; Bone Regeneration; Calcification, Physiologic; Cell Communication; Cell Movement; Cell Proliferation; Epidermal Cells; Green Fluorescent Proteins; Hedgehog Proteins; Osteoblasts; Quinazolines; Regeneration; Signal Transduction; Smoothened Receptor; Stem Cells; Time Factors; Transcription, Genetic; Veratrum Alkaloids; Zebrafish; Zebrafish Proteins	2017
Hedgehog pathway as a potential treatment target in human cholangiocarcinoma. Journal of hepato-biliary-pancreatic sciences, 2014, Volume: 21, Issue:8 Innovative treatment concepts targeting essential signaling pathways may offer new chances for patients suffering from cholangiocarcinoma (CCC). For that, we performed a systematic molecular genetic analysis concerning the Hedgehog activity in human CCC samples and analyzed the effect of Hh inhibition on CCC cells in vitro and in vivo.. Activation of the Hh pathway was analyzed in 50 human CCC samples using quantitative polymerase chain reaction (qPCR). The efficacy of Hh inhibition using cyclopamine and BMS-833923 was evaluated in vitro. In addition, the effect of BMS-833923, alone or in combination with gemcitabine, was analyzed in vivo in a murine subcutaneous xenograft model.. Expression analysis revealed a significant activation of the Hh-signaling pathway in nearly 50% of CCCs. Hh inhibition resulted in a significant decrease in cell proliferation of CCC cells. Moreover, a distinct inhibition of tumor growth could be seen as a result of a combined therapy with BMS-833923 and gemcitabine in CCC xenografts.. The results of our study suggest that the Hh pathway plays a relevant role at least in a subset of human CCC. Inhibition of this pathway may represent a possible treatment option for CCC patients in which the Hh pathway is activated. Topics: Adult; Aged; Aged, 80 and over; Animals; Benzamides; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cells, Cultured; Cholangiocarcinoma; Female; Gene Expression; Gentamicins; Hedgehog Proteins; Heterografts; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Oncogene Proteins; Patched Receptors; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Trans-Activators; Veratrum Alkaloids; Zinc Finger Protein GLI1	2014

Article

Year

Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone.

Development (Cambridge, England), 2017, 04-01, Volume: 144, Issue:7

Topics: Animal Fins; Animals; Basement Membrane; Benzamides; Bone Regeneration; Calcification, Physiologic; Cell Communication; Cell Movement; Cell Proliferation; Epidermal Cells; Green Fluorescent Proteins; Hedgehog Proteins; Osteoblasts; Quinazolines; Regeneration; Signal Transduction; Smoothened Receptor; Stem Cells; Time Factors; Transcription, Genetic; Veratrum Alkaloids; Zebrafish; Zebrafish Proteins

2017

Hedgehog pathway as a potential treatment target in human cholangiocarcinoma.

Journal of hepato-biliary-pancreatic sciences, 2014, Volume: 21, Issue:8

Innovative treatment concepts targeting essential signaling pathways may offer new chances for patients suffering from cholangiocarcinoma (CCC). For that, we performed a systematic molecular genetic analysis concerning the Hedgehog activity in human CCC samples and analyzed the effect of Hh inhibition on CCC cells in vitro and in vivo.. Activation of the Hh pathway was analyzed in 50 human CCC samples using quantitative polymerase chain reaction (qPCR). The efficacy of Hh inhibition using cyclopamine and BMS-833923 was evaluated in vitro. In addition, the effect of BMS-833923, alone or in combination with gemcitabine, was analyzed in vivo in a murine subcutaneous xenograft model.. Expression analysis revealed a significant activation of the Hh-signaling pathway in nearly 50% of CCCs. Hh inhibition resulted in a significant decrease in cell proliferation of CCC cells. Moreover, a distinct inhibition of tumor growth could be seen as a result of a combined therapy with BMS-833923 and gemcitabine in CCC xenografts.. The results of our study suggest that the Hh pathway plays a relevant role at least in a subset of human CCC. Inhibition of this pathway may represent a possible treatment option for CCC patients in which the Hh pathway is activated.

Topics: Adult; Aged; Aged, 80 and over; Animals; Benzamides; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cells, Cultured; Cholangiocarcinoma; Female; Gene Expression; Gentamicins; Hedgehog Proteins; Heterografts; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Oncogene Proteins; Patched Receptors; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Trans-Activators; Veratrum Alkaloids; Zinc Finger Protein GLI1

2014