bms-536924 and picropodophyllin

bms-536924 has been researched along with picropodophyllin* in 1 studies

Other Studies

1 other study(ies) available for bms-536924 and picropodophyllin

Article	Year
Medicinal chemistry approaches to target the kinase activity of IGF-1R. IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:6 Various drug discovery approaches have been explored in recent years to modulate the function of insulin-like growth factor-1 receptor (IGF-1R). This article focuses on the contributions of low-molecular-mass inhibitors in the modulation of IGF-1R kinase activity, and provides an update on recent reviews for this type of agent. Different classes of compounds have been demonstrated to be capable of modulating the kinase activity of IGF-1R in ways that were not possible previously. Preclinical data with some of these inhibitors support the potential application of IGF-1R-targeted therapeutic strategies in the treatment of human cancers. Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzimidazoles; Drug Evaluation, Preclinical; Humans; Neoplasms, Experimental; Podophyllotoxin; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridones; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Tyrphostins	2006

Article

Year

Medicinal chemistry approaches to target the kinase activity of IGF-1R.

IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:6

Various drug discovery approaches have been explored in recent years to modulate the function of insulin-like growth factor-1 receptor (IGF-1R). This article focuses on the contributions of low-molecular-mass inhibitors in the modulation of IGF-1R kinase activity, and provides an update on recent reviews for this type of agent. Different classes of compounds have been demonstrated to be capable of modulating the kinase activity of IGF-1R in ways that were not possible previously. Preclinical data with some of these inhibitors support the potential application of IGF-1R-targeted therapeutic strategies in the treatment of human cancers.

Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Benzimidazoles; Drug Evaluation, Preclinical; Humans; Neoplasms, Experimental; Podophyllotoxin; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridones; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Tyrphostins

2006