bms-191011 and gamma-butyrobetaine

bms-191011 has been researched along with gamma-butyrobetaine* in 1 studies

Other Studies

1 other study(ies) available for bms-191011 and gamma-butyrobetaine

Article	Year
Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 A variety of water-soluble prodrugs of BMS-191011 was synthesized and evaluated for solution state stability and rate of conversion to BMS-191011 in rat and human plasma. The deoxycarnitine ester prodrug (11c) was selected for clinical evaluation based on its superior chemical stability, crystallinity and cleavage to BMS-191011 in human plasma. Topics: Animals; Betaine; Blood; Carnitine; Crystallization; Dose-Response Relationship, Drug; Drug Stability; Heterocyclic Compounds, 3-Ring; Humans; Neuroprotective Agents; Oxadiazoles; Potassium Channels; Prodrugs; Rats; Solubility; Stroke; Structure-Activity Relationship; Water	2003

Article

Year

Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.

Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

A variety of water-soluble prodrugs of BMS-191011 was synthesized and evaluated for solution state stability and rate of conversion to BMS-191011 in rat and human plasma. The deoxycarnitine ester prodrug (11c) was selected for clinical evaluation based on its superior chemical stability, crystallinity and cleavage to BMS-191011 in human plasma.

Topics: Animals; Betaine; Blood; Carnitine; Crystallization; Dose-Response Relationship, Drug; Drug Stability; Heterocyclic Compounds, 3-Ring; Humans; Neuroprotective Agents; Oxadiazoles; Potassium Channels; Prodrugs; Rats; Solubility; Stroke; Structure-Activity Relationship; Water

2003