bms-187745 and spirohexaline

Clinically useful antibiotics, β-lactams and vancomycin, are known to inhibit bacterial cell wall peptidoglycan synthesis. Methicillin-resistant Staphylococcus aureus (MRSA) has a unique cell wall structure consisting of peptidoglycan and wall teichoic acid. In recent years, new anti-infectious agents (spirohexaline, tripropeptin C, DMPI, CDFI, cyslabdan, 1835F03, and BPH-652) targeting MRSA cell wall biosynthesis have been discovered using unique screening methods. These agents were found to inhibit important enzymes involved in cell wall biosynthesis such as undecaprenyl pyrophosphate (UPP) synthase, FemA, flippase, or UPP phosphatase. In this review, the discovery, the mechanism of action, and the future of these anti-infectious agents are described.

Topics: Acetylcysteine; Alkyl and Aryl Transferases; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Wall; Diterpenes; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mycotoxins; Organothiophosphorus Compounds; Peptidoglycan; Spiro Compounds; Teichoic Acids; Vancomycin; Virulence Factors; Xanthophylls