bm-42304 has been researched along with 2-tetradecylglycidic-acid* in 1 studies
1 other study(ies) available for bm-42304 and 2-tetradecylglycidic-acid
| Article | Year |
|---|---|
A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304).
Using two different assay systems to distinguish between overt and inner forms of carnitine palmitoyl transferase (CPT, EC 2.3.1.21) of intact guinea-pig liver mitochondria, we have shown that the hypoglycemic agent 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) inhibits the activity of carnitine-acylcarnitine translocase of liver mitochondria. The results offer an explanation for the inhibitory effect of the compound on ketogenesis with oleate but not with octanoate in the perfused guinea-pig liver, previously reported by us (Biochem. Pharmacol. 32, 3405-3412, 1983). Topics: Acyltransferases; Animals; Biological Transport; Carnitine; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; Cinnamates; Epoxy Compounds; Fatty Acids; Guinea Pigs; Hypoglycemic Agents; Intracellular Membranes; Kinetics; Male; Malonyl Coenzyme A; Mitochondria, Liver; Palmitoylcarnitine; Transferases | 1985 |