blister and benzyloxycarbonylleucyl-leucyl-leucine-aldehyde

blister has been researched along with benzyloxycarbonylleucyl-leucyl-leucine-aldehyde* in 1 studies

Other Studies

1 other study(ies) available for blister and benzyloxycarbonylleucyl-leucyl-leucine-aldehyde

Article	Year
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (New York, N.Y.), 2003, Mar-14, Volume: 299, Issue:5613 Completion of cell division during cytokinesis requires temporally and spatially regulated communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell membrane. We identified a specific inhibitor of nonmuscle myosin II, blebbistatin, that inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Using blebbistatin and other drugs, we showed that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis. Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components. Topics: Anaphase; Aurora Kinases; Cell Division; Cell Movement; Contractile Proteins; Cyclin-Dependent Kinases; DNA Replication; Enzyme Inhibitors; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Kinesins; Leupeptins; Microtubules; Mitosis; Myosin Type II; Nocodazole; Protein Serine-Threonine Kinases; Staurosporine; Ubiquitin	2003

Article

Year

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.

Science (New York, N.Y.), 2003, Mar-14, Volume: 299, Issue:5613

Completion of cell division during cytokinesis requires temporally and spatially regulated communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell membrane. We identified a specific inhibitor of nonmuscle myosin II, blebbistatin, that inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Using blebbistatin and other drugs, we showed that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis. Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components.

Topics: Anaphase; Aurora Kinases; Cell Division; Cell Movement; Contractile Proteins; Cyclin-Dependent Kinases; DNA Replication; Enzyme Inhibitors; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Kinesins; Leupeptins; Microtubules; Mitosis; Myosin Type II; Nocodazole; Protein Serine-Threonine Kinases; Staurosporine; Ubiquitin

2003