blepharismin and arbekacin

blepharismin has been researched along with arbekacin* in 1 studies

Other Studies

1 other study(ies) available for blepharismin and arbekacin

Article	Year
Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus. FEMS microbiology letters, 1997, Oct-01, Volume: 155, Issue:1 A ciliated protozoan, Blepharisma japonicum, produces a photosensitive red pigment, blepharismin (BLR). This study showed that the pigment inhibits the growth of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) resistant to arbekacin (ABK), which is the most effective aminoglycoside antibiotic against MRSA and used world wide. Although the minimum inhibitory concentration (MIC) of BLR to the ABK-resistant MRSA strain was 6.25 micrograms/ml in dark, it was decreased to 1.25 micrograms/ml by irradiation with white light of 65 W/m2 for 30 min, suggesting that the antibacterial activity of BLR is photoactivated. Our findings suggested that the antibacterial activity of BLR in dark is due to inhibition of protein synthesis. In addition, we found that BLR is bactericidal and enhances synergistically the antibacterial activity of ABK. Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Ciliophora; Dibekacin; Drug Synergism; Methicillin Resistance; Perylene; Photochemistry; Pigments, Biological; Staphylococcus aureus	1997

Article

Year

Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus.

FEMS microbiology letters, 1997, Oct-01, Volume: 155, Issue:1

A ciliated protozoan, Blepharisma japonicum, produces a photosensitive red pigment, blepharismin (BLR). This study showed that the pigment inhibits the growth of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) resistant to arbekacin (ABK), which is the most effective aminoglycoside antibiotic against MRSA and used world wide. Although the minimum inhibitory concentration (MIC) of BLR to the ABK-resistant MRSA strain was 6.25 micrograms/ml in dark, it was decreased to 1.25 micrograms/ml by irradiation with white light of 65 W/m2 for 30 min, suggesting that the antibacterial activity of BLR is photoactivated. Our findings suggested that the antibacterial activity of BLR in dark is due to inhibition of protein synthesis. In addition, we found that BLR is bactericidal and enhances synergistically the antibacterial activity of ABK.

Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Ciliophora; Dibekacin; Drug Synergism; Methicillin Resistance; Perylene; Photochemistry; Pigments, Biological; Staphylococcus aureus

1997