bisnortilidine has been researched along with nortilidine in 10 studies
| Studies (bisnortilidine) | Trials (bisnortilidine) | Recent Studies (post-2010) (bisnortilidine) | Studies (nortilidine) | Trials (nortilidine) | Recent Studies (post-2010) (nortilidine) |
|---|---|---|---|---|---|
| 11 | 4 | 5 | 17 | 7 | 6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hengy, H; Thomann, P; Vollmer, KO | 1 |
| Brennscheidt, U; Heintz, B; Jähnchen, E; Seiler, KU; Trenk, D | 1 |
| Hajda, JP; Jähnchen, E; Oie, S; Trenk, D | 1 |
| Kuepper, U; Madea, B; Musshoff, F; Trafkowski, J | 1 |
| Dettmeyer, R; Madea, B; Thierauf, A; Wollersen, H | 1 |
| Binscheck, T; Grobosch, T; Köhler, C | 1 |
| Mikus, G; Riedel, KD; Weiss, J; Wustrow, I | 1 |
| Grün, B; Merkel, U; Mikus, G; Riedel, KD; Weiss, J | 1 |
| Blank, A; Burhenne, J; Eichbaum, C; Markert, C; Mathes, K; Mikus, G | 1 |
| Blank, A; Burhenne, J; Emrich, O; Meid, AD; Merbach, M; Mikus, G; Stammler, G; Wolfert, C | 1 |
4 trial(s) available for bisnortilidine and nortilidine
| Article | Year |
|---|---|
Pharmacokinetics of tilidine in terminal renal failure.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prodrugs; Renal Dialysis; Tilidine | 2001 |
Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Cross-Over Studies; Humans; Injections, Intravenous; Male; Models, Biological; Prodrugs; Tilidine; Time Factors | 2002 |
Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Genotype; Half-Life; Humans; Male; Middle Aged; Naloxone; Polymorphism, Genetic; Prodrugs; Ritonavir; Tilidine; Time Factors; Young Adult | 2012 |
Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine.
Topics: Adult; Alkynes; Analgesics, Opioid; Benzoxazines; Beverages; Chromatography, Liquid; Citrus paradisi; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP3A; Female; Half-Life; Humans; Male; Middle Aged; Tandem Mass Spectrometry; Tilidine; Young Adult | 2015 |
6 other study(ies) available for bisnortilidine and nortilidine
| Article | Year |
|---|---|
Pharmacokinetics of tilidine and metabolites in man.
Topics: Administration, Oral; Adult; Chromatography, Gas; Cyclohexanecarboxylic Acids; Half-Life; Humans; Injections, Intravenous; Male; Tilidine | 1989 |
An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Humans; Morphine Derivatives; Palliative Care; Patient Compliance; Spectrometry, Mass, Electrospray Ionization; Tilidine | 2006 |
Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Central Nervous System Depressants; Coronary Vessel Anomalies; Female; Forensic Pathology; Humans; Myocardium; Pyrethrins; Tilidine; Trimipramine | 2007 |
Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS.
Topics: Automation; Chromatography, Liquid; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tilidine | 2011 |
In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Tilidine | 2012 |
[Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism].
Topics: Adult; Aged; Aged, 80 and over; Chronic Pain; Delayed-Action Preparations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Quality of Life; Tilidine | 2017 |