bismuth-subgallate and bismuth-tripotassium-dicitrate

The absorption of bismuth from five 205Bi-labelled pharmaceutically used bismuth compounds was studied in man. From single oral doses of all compounds under investigation only less than 0.1% bismuth was absorbed and excreted with the urine. A significantly higher absorption was observed from the colloidal bismuth subcitrate (0.042% of the dose) and the basic bismuth gallate (0.038%) than from the basic bismuth salicylate, nitrate, and aluminate (0.005-0.002%). No retention of bismuth in the whole body was found from the single dose experiment. The biologic fast-term half-lives of absorbed bismuth were calculated to be 0.12 and 1.5 days.

Topics: Adult; Aluminum; Anti-Ulcer Agents; Biological Availability; Bismuth; Female; Gallic Acid; Humans; Intestinal Absorption; Male; Middle Aged; Nitrates; Organometallic Compounds; Peptic Ulcer; Radioisotopes

The minimum inhibitory concentrations of five bismuth salts (bismuth subcitrate, bismuth subgallate, bismuth subnitrate, bismuth subsalicylate and tripotassium dicitrato bismuthate, a water soluble compound of bismuth subcitrate) were assayed against 48 strains of Campylobacter pylori employing the agar dilution method. Tripotassium dicitrato bismuthate was most effective (MIC50 8 mg/l), the other bismuth salts exhibited somewhat lower inhibitory activities. It is concluded that bismuth salts are suitable agents for inhibiting growth of Campylobacter pylori.

Topics: Antacids; Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Campylobacter; Gallic Acid; Humans; Molecular Structure; Organometallic Compounds; Salicylates