bisabolangelone and isoimperatorin

bisabolangelone has been researched along with isoimperatorin* in 2 studies

Other Studies

2 other study(ies) available for bisabolangelone and isoimperatorin

Article	Year
[Chemical constituents of antibacterial activity fraction of Angelica polymorpha]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008, Volume: 31, Issue:8 To study chemical constituents of antibacterial activity fraction of Angelica polymorpha.. Compounds were isolated by repeatedly silica gel column chromatography and recrystallization. Their structures were identified by physical and chemical evidences and spectral methods.. Seven compounds were obtained from the antibacterial activity fraction, their structures were elucidated as: bisabolangelone(I), isoimperatorin (II), oxypeucedanine(III), isooxypeucedanine(IV), oxypeucedanin hydrate(V), bergapten(VI), pabulenol(VII).. Bisabolangelone(I) is obtained from this plant for the first time. Compound (II)-(VII) belong to linear furanocourmarins. Topics: 5-Methoxypsoralen; Angelica; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Coumarins; Ficusin; Furocoumarins; Methoxsalen; Plant Roots; Plants, Medicinal; Sesquiterpenes	2008
Inhibitors of 5alpha -reductase type I in LNCaP cells from the roots of Angelica koreana. Planta medica, 2002, Volume: 68, Issue:2 A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5alpha-reductase type I inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5alpha-reductase type I in LNCaP cells with an IC50 value of 0.1 microg/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 microg/ml). Bisabolangelone also inhibited the activity of 5alpha-reductase type I in LNCaP cells (IC50 = 11.6 microg/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5 alpha-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5alpha-reductase assay systems used in the present study. Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Angelica; Coumarins; Finasteride; Furocoumarins; Humans; Male; Medicine, East Asian Traditional; Plant Extracts; Plant Roots; Sesquiterpenes; Testosterone; Tumor Cells, Cultured	2002

Article

Year

[Chemical constituents of antibacterial activity fraction of Angelica polymorpha].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008, Volume: 31, Issue:8

To study chemical constituents of antibacterial activity fraction of Angelica polymorpha.. Compounds were isolated by repeatedly silica gel column chromatography and recrystallization. Their structures were identified by physical and chemical evidences and spectral methods.. Seven compounds were obtained from the antibacterial activity fraction, their structures were elucidated as: bisabolangelone(I), isoimperatorin (II), oxypeucedanine(III), isooxypeucedanine(IV), oxypeucedanin hydrate(V), bergapten(VI), pabulenol(VII).. Bisabolangelone(I) is obtained from this plant for the first time. Compound (II)-(VII) belong to linear furanocourmarins.

Topics: 5-Methoxypsoralen; Angelica; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Coumarins; Ficusin; Furocoumarins; Methoxsalen; Plant Roots; Plants, Medicinal; Sesquiterpenes

2008

Inhibitors of 5alpha -reductase type I in LNCaP cells from the roots of Angelica koreana.

Planta medica, 2002, Volume: 68, Issue:2

A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5alpha-reductase type I inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5alpha-reductase type I in LNCaP cells with an IC50 value of 0.1 microg/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 microg/ml). Bisabolangelone also inhibited the activity of 5alpha-reductase type I in LNCaP cells (IC50 = 11.6 microg/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5 alpha-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5alpha-reductase assay systems used in the present study.

Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Angelica; Coumarins; Finasteride; Furocoumarins; Humans; Male; Medicine, East Asian Traditional; Plant Extracts; Plant Roots; Sesquiterpenes; Testosterone; Tumor Cells, Cultured

2002