bis(7)-tacrine has been researched along with ebselen* in 1 studies
1 other study(ies) available for bis(7)-tacrine and ebselen
| Article | Year |
|---|---|
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
A series of tacrine-ebselen hybrids were synthesised and evaluated as possible multifunctional anti-Alzheimer's disease (AD) agents. Compound 6i, which is tacrine linked with 5,6-dimethoxybenzo[d][1,2]selenazol-3(2H)-one by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) and butylcholinesterase (BuChE) inhibitor, with IC50 values of 2.55 and 2.80 nM, respectively. Furthermore, this compound demonstrated similar hydrogen peroxide and peroxynitrite scavenging activity as ebselen by horseradish peroxidase assay and peroxynitrite scavenging activity assay, indicating that this hybrid is a good multifunctional drug candidate for the treatment of AD. Topics: Acetylcholinesterase; Animals; Azoles; Binding Sites; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Free Radical Scavengers; Horses; Humans; Hydrogen Peroxide; Isoindoles; Kinetics; Molecular Docking Simulation; Organoselenium Compounds; Peroxynitrous Acid; Protein Binding; Protein Structure, Tertiary; Tacrine | 2013 |