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bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate and tamoxifen

bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate has been researched along with tamoxifen in 11 studies

Compound Research Comparison

Studies
(bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate)
Trials
(bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate)
Recent Studies (post-2010)
(bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate)
Studies
(tamoxifen)
Trials
(tamoxifen)
Recent Studies (post-2010) (tamoxifen)
401220,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomybis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's8 (72.73)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belanger, A; Gauthier, S; Labrie, C; Labrie, F; Merand, Y; Poirier, D; Sanchez, R; Simard, J; Singh, SM1
Jeannin, E; Liu, JW; Picard, D1
Bélanger, A; Giguère, V; Labrie, C; Labrie, F; Simard, J; Tremblay, A; Tremblay, G1
Gajdos, C; Jordan, VC1
Candas, B; Couillard, S; Gutman, M; Labrie, C; Labrie, F; Roy, J1
Bai, Y; Giguére, V1
Briand, P; Jensen, J; Kitlen, JW; Labrie, F; Lykkesfeldt, AE1
Basrur, V; Rowan, BG; Shah, YM1
Al-Dhaheri, MH; Basrur, V; Pind, S; Rowan, BG; Shah, YM1
Griekspoor, A; Michalides, R; Neefjes, J; Rondaij, M; Verwoerd, D; Zwart, W1
Belleau, P; Calvo, E; Labrie, F; Luu-The, V; Martel, C1

Reviews

2 review(s) available for bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate and tamoxifen

ArticleYear
EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5

    Topics: Animals; Benzopyrans; Breast; Breast Neoplasms; Cholesterol; Endometrial Neoplasms; Endometrium; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Mammary Neoplasms, Experimental; Mice; Neoplasms, Hormone-Dependent; Osteoporosis; Piperidines; Propionates; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Transcription, Genetic; Triglycerides; Tumor Cells, Cultured

2001
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
    Clinical breast cancer, 2002, Volume: 2, Issue:4

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome

2002

Other Studies

9 other study(ies) available for bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate and tamoxifen

ArticleYear
Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Adenocarcinoma; Alkaline Phosphatase; Benzopyrans; Endometrial Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Neoplasm Proteins; Piperidines; Propionates; Raloxifene Hydrochloride; Tamoxifen; Toremifene; Tumor Cells, Cultured

1997
The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system.
    Biological chemistry, 1999, Volume: 380, Issue:11

    Topics: Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Humans; Indoles; Nafoxidine; Piperidines; Polyunsaturated Alkamides; Receptors, Estrogen; Saccharomyces cerevisiae; Sulfones; Tamoxifen; Two-Hybrid System Techniques

1999
Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice.
    International journal of cancer, 2002, May-10, Volume: 99, Issue:2

    Topics: Animals; Breast Neoplasms; Cell Division; Cell Size; Cinnamates; Endometrium; Epithelial Cells; Estrogen Antagonists; Estrone; Female; Humans; Kinetics; Mice; Mice, Nude; Neoplasm Transplantation; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Stilbenes; Tamoxifen; Toremifene; Tumor Cells, Cultured

2002
Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:4

    Topics: Acetyltransferases; Bacterial Proteins; Cells, Cultured; Dimerization; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; Histone Acetyltransferases; Humans; Luminescent Proteins; Mutation; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivator 3; Oncogene Proteins; Piperidines; Protein Isoforms; Protein Structure, Tertiary; Receptor, ErbB-2; Receptors, Estrogen; Recombinant Proteins; Signal Transduction; Tamoxifen; Trans-Activators; Transcription Factors

2003
Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:4

    Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Division; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Fulvestrant; Humans; Ligands; Membrane Proteins; Piperidines; Presenilin-2; Protein Binding; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Time Factors; Tumor Cells, Cultured

2003
Selective estrogen receptor modulator regulated proteins in endometrial cancer cells.
    Molecular and cellular endocrinology, 2004, Apr-30, Volume: 219, Issue:1-2

    Topics: Biomarkers; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Estradiol; Female; Heterogeneous-Nuclear Ribonucleoprotein Group F-H; HSP90 Heat-Shock Proteins; Humans; Keratins; Lactoferrin; Neoplasm Proteins; Phosphoproteins; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Ubiquitin-Conjugating Enzymes

2004
Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells.
    Steroids, 2006, Volume: 71, Issue:11-12

    Topics: Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Humans; Molecular Sequence Data; Neoplasm Proteins; Piperidines; Tamoxifen

2006
Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:5

    Topics: Bacterial Proteins; Cell Line, Tumor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fluorescence Resonance Energy Transfer; Fulvestrant; Humans; Luminescent Proteins; Models, Biological; Models, Chemical; Mutation; Piperidines; Tamoxifen; Transcriptional Activation

2007
Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland.
    Breast cancer research and treatment, 2012, Volume: 134, Issue:2

    Topics: Animals; Cluster Analysis; Estradiol; Estrogen Antagonists; Estrogens; Female; Fulvestrant; Gene Expression Regulation; Genes; Genes, Neoplasm; Mammary Glands, Animal; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Transcriptome

2012