bis(3--5-)-cyclic-diguanylic-acid and benzothiazole

bis(3--5-)-cyclic-diguanylic-acid has been researched along with benzothiazole* in 1 studies

Other Studies

1 other study(ies) available for bis(3--5-)-cyclic-diguanylic-acid and benzothiazole

Article	Year
Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors. Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15 The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be associated with a sessile biofilm lifestyle of pathogens. A promising antibiofilm strategy involving the induction of c-di-GMP to form dysfunctional G-quadruplexes, thereby blocking the c-di-GMP-mediated biofilm regulatory pathway, was proposed in this study. In this new strategy, a series of novel c-di-GMP G-quadruplex inducers were designed and synthesized for development of therapeutic biofilm inhibitors. Compound Topics: Anti-Bacterial Agents; Benzothiazoles; Biofilms; Cyclic GMP; Dose-Response Relationship, Drug; Drug Design; G-Quadruplexes; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Quinolines; Structure-Activity Relationship	2021

Article

Year

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.

Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15

The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be associated with a sessile biofilm lifestyle of pathogens. A promising antibiofilm strategy involving the induction of c-di-GMP to form dysfunctional G-quadruplexes, thereby blocking the c-di-GMP-mediated biofilm regulatory pathway, was proposed in this study. In this new strategy, a series of novel c-di-GMP G-quadruplex inducers were designed and synthesized for development of therapeutic biofilm inhibitors. Compound

Topics: Anti-Bacterial Agents; Benzothiazoles; Biofilms; Cyclic GMP; Dose-Response Relationship, Drug; Drug Design; G-Quadruplexes; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Quinolines; Structure-Activity Relationship

2021