Compounds > birb 796
Page last updated: 2024-09-04

birb 796 and zd 6474

birb 796 has been researched along with zd 6474 in 6 studies

Compound Research Comparison

Studies
(birb 796)		Trials
(birb 796)		Recent Studies (post-2010)
(birb 796)		Studies
(zd 6474)		Trials
(zd 6474)		Recent Studies (post-2010) (zd 6474)
13758062388413

Protein Interaction Comparison

ProteinTaxonomybirb 796 (IC50)zd 6474 (IC50)
Tyrosine-protein kinase ABL1Homo sapiens (human)0.1185
Epidermal growth factor receptorHomo sapiens (human)0.5373
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)1.6
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.7738
Platelet-derived growth factor receptor betaHomo sapiens (human)0.7885
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.343
Fibroblast growth factor receptor 1Homo sapiens (human)2.7925
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0769
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.5812
Kinesin-1 heavy chainHomo sapiens (human)0.4
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.1464
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.5425
Angiopoietin-1 receptorHomo sapiens (human)1.5335
Macrophage-stimulating protein receptorHomo sapiens (human)3.37
Coiled-coil domain-containing protein 6Homo sapiens (human)0.02
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.2

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Russu, WA; Shallal, HM1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

6 other study(ies) available for birb 796 and zd 6474

ArticleYear
A small molecule-kinase interaction map for clinical kinase inhibitors.
    Nature biotechnology, 2005, Volume: 23, Issue:3

    Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines

2005
A quantitative analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2008, Volume: 26, Issue:1

    Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship

2008
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship

2011
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013