Page last updated: 2024-09-04

birb 796 and s 1033

birb 796 has been researched along with s 1033 in 5 studies

Compound Research Comparison

Studies
(birb 796)
Trials
(birb 796)
Recent Studies (post-2010)
(birb 796)
Studies
(s 1033)
Trials
(s 1033)
Recent Studies (post-2010) (s 1033)
1375801,4071471,074

Protein Interaction Comparison

ProteinTaxonomybirb 796 (IC50)s 1033 (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)4.7
Solute carrier family 22 member 3Homo sapiens (human)0.5
Tyrosine-protein kinase ABL1Homo sapiens (human)0.34
Low-density lipoprotein receptorHomo sapiens (human)9.8
FibronectinHomo sapiens (human)0.12
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)1.1
Tyrosine-protein kinase LckHomo sapiens (human)0.1082
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.677
Tyrosine-protein kinase LynHomo sapiens (human)1.281
Cytochrome P450 3A4Homo sapiens (human)0.58
Macrophage colony-stimulating factor 1 receptorMus musculus (house mouse)0.534
Platelet-derived growth factor receptor betaHomo sapiens (human)0.052
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.1115
Breakpoint cluster region proteinHomo sapiens (human)0.0575
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.01
Solute carrier family 2, facilitated glucose transporter member 4Mus musculus (house mouse)0.042
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.0905
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0368
Ephrin type-A receptor 2Homo sapiens (human)0.033
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)9.548
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)4.7
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.0371
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2879
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)4.7
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)4.7
Discoidin domain-containing receptor 2Homo sapiens (human)0.0289
Proprotein convertase subtilisin/kexin type 9Homo sapiens (human)9.8
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2.5

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Engel, J; Grütter, C; Nguyen, HD; Phan, T; Rauh, D; Richters, A; Simard, JR1
Ding, K; Li, Y; Lu, X; Ren, X1
Appelmann, I; Brümmendorf, TH; Kharabi Masouleh, B; Patterson, JB; Preisinger, C; Salimi, A; Samali, A; Schemionek, M; Vieri, M1

Reviews

1 review(s) available for birb 796 and s 1033

ArticleYear
Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.
    Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8

    Topics: Amino Acid Sequence; Animals; Discoidin Domain Receptors; Drug Discovery; Humans; Inflammation; Ligands; Models, Molecular; Molecular Sequence Data; Neoplasms; Protein Conformation; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Small Molecule Libraries

2015

Other Studies

4 other study(ies) available for birb 796 and s 1033

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Identification of type II and III DDR2 inhibitors.
    Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10

    Topics: Discoidin Domain Receptors; Drug Design; Fluorescence; High-Throughput Screening Assays; Ligands; Protein Kinase Inhibitors; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Structure-Activity Relationship

2014
Targeting of BCR-ABL1 and IRE1α induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia.
    Carcinogenesis, 2021, 02-25, Volume: 42, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzopyrans; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Endoribonucleases; Fusion Proteins, bcr-abl; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice, Transgenic; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrimidines; Synthetic Lethal Mutations; X-Box Binding Protein 1

2021