birb 796 has been researched along with 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea in 7 studies
| Studies (birb 796) | Trials (birb 796) | Recent Studies (post-2010) (birb 796) | Studies (1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea) | Trials (1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea) | Recent Studies (post-2010) (1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea) |
|---|---|---|---|---|---|
| 137 | 5 | 80 | 13 | 0 | 1 |
| Protein | Taxonomy | birb 796 (IC50) | 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea (IC50) |
|---|---|---|---|
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 0.7943 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Churchill, L; Cirillo, PF; Gilmore, T; Graham, AG; Grob, PM; Hickey, ER; Moss, N; Pargellis, C; Pav, S; Regan, J; Tong, L | 1 |
| Breitfelder, S; Cirillo, P; Gilmore, T; Graham, AG; Hickey, E; Klaus, B; Madwed, J; Moriak, M; Moss, N; Pargellis, C; Pav, S; Proto, A; Regan, J; Swinamer, A; Tong, L; Torcellini, C | 1 |
| Cirillo, PF; Gilmore, T; Hickey, ER; Moss, N; Pargellis, CA; Peet, GW; Proto, A; Regan, J; Swinamer, A | 1 |
| Fuschetto, NG; Ingraham, RH; Kroe, RR; Landro, LD; Pargellis, CA; Peet, GW; Proto, A; Regan, J; Roy, T | 1 |
| Gray, NS; Liu, Y | 1 |
| Getlik, M; Grütter, C; Klüter, S; Naqvi, T; Pawar, V; Rabiller, M; Rauh, D; Simard, JR | 1 |
| Leeson, PD; Young, RJ | 1 |
1 review(s) available for birb 796 and 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea
| Article | Year |
|---|---|
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.
Topics: Animals; Chemical Phenomena; Drug Discovery; Humans; Hydrophobic and Hydrophilic Interactions | 2018 |
6 other study(ies) available for birb 796 and 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea
| Article | Year |
|---|---|
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Topics: Allosteric Site; Amino Acid Motifs; Cell Line; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Mitogen-Activated Protein Kinases; Models, Molecular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Conformation; Pyrazoles; Substrate Specificity; Time Factors | 2002 |
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Enzyme Inhibitors; Female; Fluorescence; Humans; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Models, Molecular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyrazoles; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Urea | 2002 |
The kinetics of binding to p38MAP kinase by analogues of BIRB 796.
Topics: Autoimmune Diseases; Drug Design; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Kinetics; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Structure-Activity Relationship | 2003 |
Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.
Topics: Algorithms; Allosteric Site; Animals; Binding Sites; Calorimetry, Differential Scanning; Enzyme Inhibitors; Fluorescence; Heating; Humans; Mice; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Protein Binding; Protein Denaturation; Protein Folding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Urea | 2003 |
Rational design of inhibitors that bind to inactive kinase conformations.
Topics: Binding Sites; Drug Design; Humans; Models, Molecular; Phosphotransferases; Protein Kinase Inhibitors; Protein Structure, Tertiary | 2006 |
Displacement assay for the detection of stabilizers of inactive kinase conformations.
Topics: Crystallography, X-Ray; Drug Design; Mitogen-Activated Protein Kinase 9; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Protein Conformation; Protein Kinase Inhibitors; Pyrazoles; Structure-Activity Relationship; Urea | 2010 |