biotin has been researched along with beta-hydroxyisovaleric acid in 36 studies
| Studies (biotin) | Trials (biotin) | Recent Studies (post-2010) (biotin) | Studies (beta-hydroxyisovaleric acid) | Trials (beta-hydroxyisovaleric acid) | Recent Studies (post-2010) (beta-hydroxyisovaleric acid) |
|---|---|---|---|---|---|
| 14,847 | 95 | 3,882 | 442 | 134 | 278 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (19.44) | 18.7374 |
| 1990's | 10 (27.78) | 18.2507 |
| 2000's | 14 (38.89) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Mock, DM; Mock, NI | 1 |
| Jackson, H; Lankford, GL; Mock, DM; Mock, NI; Weintraub, ST | 1 |
| Holme, E; Jacobson, CE; Kristiansson, B | 1 |
| Mock, DM; Mock, NI; Weintraub, S | 1 |
| Baker, H; Baswell, DL; Holman, RT; Mock, DM; Sweetman, L | 1 |
| Erasmus, C; Mienie, LJ; Reinecke, CJ; Wadman, SK | 1 |
| Bartlett, K; Leonard, JV; Ng, H | 1 |
| Sweetman, L | 1 |
| Berry, SA; Nyhan, WL; Thuy, LP; Tuchman, M | 1 |
| Baumgartner, ER; Lehnert, W; Niederhoff, H; Suormala, T | 1 |
| Bishop, WP; Malik, MI; Mock, DM; Mock, NI; Stumbo, PJ | 1 |
| Mock, DM; Mock, NI; Stadler, DD; Stratton, SL | 1 |
| Mock, DM; Stadler, DD | 1 |
| Dyken, ME; Mock, DM | 1 |
| Engelbrecht, V; Gärtner, J; Lenard, HG; Lohmeier, K; Schürmann, M; Wendel, U | 1 |
| Lombard, KA; Mock, DM; Mock, NI; Nelson, RP | 1 |
| Mock, DM | 1 |
| Helm, RM; Mock, DM; Mock, NI; Simpson, P | 1 |
| Mock, DM; Mock, NI; Quirk, JG | 1 |
| Boylan, J; Cannon, MJ; Cederbaum, S; Cress, S; Jennings, ML; Mardach, R; Mock, DM; Roth, S; Wolf, B; Zempleni, J | 1 |
| Carnell, N; Henrich, CL; Mock, DM; Mock, NI | 1 |
| Aoki, Y; Baumgartner, ER; Duran, M; Muhle, H; Santer, R; Stephani, U; Suormala, T; Suzuki, Y; Yang, X | 1 |
| Almashanu, S; Baumgartner, ER; Baumgartner, MR; Dantas, MF; Fowler, B; Friebel, D; Gebhardt, B; Giunta, C; Hoffmann, GF; Suormala, T; Valle, D | 1 |
| Mock, DM; Sealey, WM; Stratton, SL; Teague, AM | 1 |
| Fukui, T; Kumasaka, K | 1 |
| Ebara, S; Fukui, T; Oguchi, K; Watanabe, T | 1 |
| Bogusiewicz, A; Mock, DM; Mock, MM; Mock, NI; Stratton, SL; Wells, AM | 1 |
| Ferreira, G; Weiss, WP; Willett, LB | 1 |
| López-Rosas, I; Rodríguez-Fuentes, N; Román-Cisneros, G; Velázquez-Arellano, A | 1 |
| Ebara, S; Fukui, T; Kimura, S; Nagai, Y; Taniguchi, A; Watanabe, T | 1 |
| Barshop, BA; Gangoiti, J; Nyhan, WL; Willis, M | 1 |
| Boysen, G; Horvath, TD; Matthews, NI; Mock, DM; Stratton, SL | 1 |
| Bogusiewicz, A; Boysen, G; Dawson, AM; Henrich, CL; Horvath, TD; Matthews, NI; Mock, DM; Moran, JH; Owen, SN; Spencer, HJ; Stratton, SL | 1 |
| Caudill, MA; Gayle, A; Jiang, X; Lucas, LK; Malysheva, O; Perry, CA; West, AA; Yan, J | 1 |
| Nakamura, T; Shibata, K; Tsuji, A | 1 |
| Deng, Z; He, H; Hong, Q; Liu, S; Luo, X; Zhang, Y; Zheng, X | 1 |
2 review(s) available for biotin and beta-hydroxyisovaleric acid
| Article | Year |
|---|---|
Biotin status: which are valid indicators and how do we know?
Topics: Animals; Biotin; Female; Humans; Nutritional Status; Pregnancy; Valerates | 1999 |
[Biotin (vitamin H)].
Topics: Biological Assay; Biomarkers; Biotin; Biotinidase; Biotinidase Deficiency; Dermatitis, Atopic; Epilepsies, Partial; Humans; Reference Values; Specimen Handling; Valerates | 2004 |
3 trial(s) available for biotin and beta-hydroxyisovaleric acid
| Article | Year |
|---|---|
Marginal biotin deficiency during normal pregnancy.
Topics: Adult; Biotin; Deficiency Diseases; Female; Humans; Pregnancy; Pregnancy Complications; Valerates | 2002 |
Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans.
Topics: Adult; Analysis of Variance; Biomarkers; Biotin; Cross-Over Studies; Deficiency Diseases; Female; Humans; Lymphocytes; Male; Methylmalonyl-CoA Decarboxylase; Nutrition Assessment; Nutritional Status; Sensitivity and Specificity; Valerates | 2006 |
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
Topics: Adult; Biomarkers; Biotin; Carbon-Carbon Ligases; Carnitine; Choline; Chromatography, Liquid; Diet; Dietary Supplements; Female; Humans; Lactation; Leucine; Milk, Human; New York; Patient Compliance; Pregnancy; Tandem Mass Spectrometry; Valerates; Young Adult | 2014 |
31 other study(ies) available for biotin and beta-hydroxyisovaleric acid
| Article | Year |
|---|---|
Biotin deficiency in rats: disturbances of leucine metabolism are detectable early.
Topics: Animals; Biotin; Gas Chromatography-Mass Spectrometry; Leucine; Male; Rats; Rats, Inbred Strains; Valerates | 1992 |
Quantification of urinary 3-hydroxyisovaleric acid using deuterated 3-hydroxyisovaleric acid as internal standard.
Topics: Animals; Biotin; Deuterium; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Rats; Reference Standards; Valerates | 1989 |
Biotin-responsive multiple carboxylase deficiency in an 8-year-old boy with normal serum biotinidase and fibroblast holocarboxylase-synthetase activities.
Topics: Amidohydrolases; Biotin; Biotinidase; Carbon-Nitrogen Ligases; Child; Fibroblasts; Glycine; Humans; Kinetics; Ligases; Male; Multiple Carboxylase Deficiency; Valerates | 1988 |
Abnormal organic aciduria in biotin deficiency: the rat is similar to the human.
Topics: Animals; Biotin; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glycine; Male; Random Allocation; Rats; Rats, Inbred Strains; Valerates | 1988 |
Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment.
Topics: Alopecia; Biotin; Citrates; Diagnosis, Differential; Erythema; Fatty Acids, Essential; Female; Glycine; Humans; Infant; Isomerism; Lactates; Lactic Acid; Male; Nervous System Diseases; Parenteral Nutrition; Valerates; Zinc | 1985 |
Organic aciduria in late-onset biotin-responsive multiple carboxylase deficiency.
Topics: Biotin; Carbon-Carbon Ligases; Carboxy-Lyases; Female; Humans; Infant; Lactates; Lactic Acid; Ligases; Methylmalonyl-CoA Decarboxylase; Pyruvate Carboxylase Deficiency Disease; Valerates | 1985 |
A combined defect of three mitochondrial carboxylases presenting as biotin-responsive 3-methylcrotonyl glycinuria and 3-hydroxyisovaleric aciduria.
Topics: Acidosis; Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Biotin; Butyrates; Carbon Dioxide; Carboxy-Lyases; Child, Preschool; Crotonates; Female; Fibroblasts; Glycine; Humans; Hydroxy Acids; Ligases; Mitochondria; Propionates; Pyruvate Carboxylase Deficiency Disease; Valerates | 1980 |
Two forms of biotin-responsive multiple carboxylase deficiency.
Topics: Acute Disease; Biotin; Carbon-Carbon Ligases; Chronic Disease; Fibroblasts; Humans; Hydroxy Acids; Infant; Lactates; Lactic Acid; Ligases; Lymphocytes; Pyruvate Carboxylase Deficiency Disease; Valerates | 1981 |
Partial methylcrotonyl-coenzyme A carboxylase deficiency in an infant with failure to thrive, gastrointestinal dysfunction, and hypertonia.
Topics: Biotin; Carbon-Carbon Ligases; Failure to Thrive; Gastrointestinal Diseases; Glycine; Humans; Infant; Ligases; Male; Metabolism, Inborn Errors; Muscle Hypertonia; Valerates | 1993 |
Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency: long-term outcome in a case with neonatal onset.
Topics: Age of Onset; Biotin; Carbon-Carbon Ligases; Developmental Disabilities; Diet, Protein-Restricted; Epilepsy, Generalized; Humans; Infant, Newborn; Ligases; Male; Metabolism, Inborn Errors; Patient Compliance; Valerates | 1996 |
Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency.
Topics: Adult; Analysis of Variance; Avidin; Biotin; Chromatography, High Pressure Liquid; Egg White; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Valerates | 1997 |
Biotin status assessed longitudinally in pregnant women.
Topics: Adult; Analysis of Variance; Biotin; Biotransformation; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Longitudinal Studies; Pregnancy; Retrospective Studies; Valerates | 1997 |
Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy.
Topics: Adult; Biotin; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Gas Chromatography-Mass Spectrometry; Humans; Nutritional Status; Pregnancy; Reference Values; Valerates | 1997 |
Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Biotin; Epilepsy; Female; Humans; Male; Middle Aged; Time Factors; Valerates | 1997 |
Cerebral metabolic changes in biotinidase deficiency.
Topics: Amidohydrolases; Biotin; Biotinidase; Brain; Electroencephalography; Humans; Infant; Lactic Acid; Magnetic Resonance Imaging; Male; Pyruvic Acid; Seizures; Valerates | 1997 |
Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy.
Topics: Anticonvulsants; Biotin; Carbamazepine; Child; Female; Humans; Male; Phenobarbital; Phenytoin; Valerates | 1998 |
Certain immune markers are not good indicators of mild to moderate biotin deficiency in rats.
Topics: Animals; Biomarkers; Biotin; Carbon-Carbon Ligases; Cell Division; Cells, Cultured; Cytokines; Haemophilus Vaccines; Immunoglobulin G; Interferon-gamma; Interleukin-4; Killer Cells, Natural; Leukocytes, Mononuclear; Liver; Lymphocyte Activation; Lymphocyte Subsets; Lymphocytes; Male; Rats; Rats, Sprague-Dawley; Spleen; Thymus Gland; Valerates | 2001 |
Biotin dependency due to a defect in biotin transport.
Topics: Amidohydrolases; Biological Transport; Biotin; Biotinidase; Carbon-Carbon Ligases; Carboxy-Lyases; Carrier Proteins; Cell Line, Transformed; Child, Preschool; Female; Humans; Lactic Acid; Leukocytes, Mononuclear; Male; Membrane Glycoproteins; Methylmalonyl-CoA Decarboxylase; Pyruvate Carboxylase; Substance Withdrawal Syndrome; Symporters; Valerates | 2002 |
Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge.
Topics: Adult; Biotin; Diet; Dose-Response Relationship, Drug; Egg White; Female; Humans; Leucine; Male; Time Factors; Valerates | 2002 |
Partial response to biotin therapy in a patient with holocarboxylase synthetase deficiency: clinical, biochemical, and molecular genetic aspects.
Topics: Age of Onset; Biotin; Carbon-Carbon Ligases; Carbon-Nitrogen Ligases; Child; DNA Mutational Analysis; Female; Genes, Recessive; Holocarboxylase Synthetase Deficiency; Humans; Methylmalonyl-CoA Decarboxylase; Mutation; Phenotype; Pyruvate Carboxylase; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing; Valerates | 2003 |
Isolated 3-methylcrotonyl-CoA carboxylase deficiency: evidence for an allele-specific dominant negative effect and responsiveness to biotin therapy.
Topics: Alleles; Base Sequence; Biotin; Carbon-Carbon Ligases; DNA Mutational Analysis; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Genetic Vectors; Germany; Glycine; Greece; Humans; Infant, Newborn; Male; Mitochondrial Diseases; Molecular Sequence Data; Mutation; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Transfection; Valerates | 2004 |
Smoking accelerates biotin catabolism in women.
Topics: Adult; Avidin; Biomarkers; Biotin; Carbon-Carbon Ligases; Case-Control Studies; Chromatography, High Pressure Liquid; Cohort Studies; Creatinine; Female; Humans; Male; Middle Aged; Sex Factors; Smoking; Valerates | 2004 |
Measurement of 3-hydroxyisovaleric acid in urine of biotin-deficient infants and mice by HPLC.
Topics: Animals; Biomarkers; Biotin; Chromatography, High Pressure Liquid; Deficiency Diseases; Humans; Infant; Male; Mice; Mice, Inbred ICR; Regression Analysis; Valerates | 2005 |
Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin.
Topics: Animals; Biotin; Cattle; Dairying; Diet; Dietary Supplements; Fatty Acids, Volatile; Female; Lactation; Milk; Rumen; Time Factors; Valerates | 2007 |
Biotin deficiency affects both synthesis and degradation of pyruvate carboxylase in rat primary hepatocyte cultures.
Topics: Animals; Biotin; Biotinylation; Hepatocytes; Lymphocytes; Male; Methylmalonyl-CoA Decarboxylase; Pyruvate Carboxylase; Rats; Rats, Wistar; Valerates | 2007 |
Effects of biotin deficiency on embryonic development in mice.
Topics: Animals; Biotin; Chromatography, High Pressure Liquid; Congenital Abnormalities; Embryonic Development; Energy Metabolism; Female; Fetus; Gestational Age; Male; Mice; Mice, Inbred ICR; Nutritional Requirements; Pregnancy; Pregnancy Outcome; Pregnancy, Animal; Random Allocation; Valerates | 2009 |
Positive newborn screen in the biochemically normal infant of a mother with treated holocarboxylase synthetase deficiency.
Topics: Adult; Biotin; Carnitine; False Positive Reactions; Female; Holocarboxylase Synthetase Deficiency; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Neonatal Screening; Pregnancy; Pregnancy Complications; Valerates | 2009 |
Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS.
Topics: Adult; Biomarkers; Biotin; Biotinidase Deficiency; Calibration; Chromatography, Liquid; Creatinine; Egg White; Female; Humans; Male; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Valerates | 2011 |
Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.
Topics: Adult; Biotin; Carnitine; Cohort Studies; Female; Humans; Leucine; Male; Valerates | 2011 |
Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes.
Topics: Animals; Biotin; Body Weight; Cell Count; Chromosome Aberrations; Diet; Eating; Estradiol; Estrous Cycle; Female; Liver; Mice; Mice, Inbred ICR; Oocytes; Organ Size; Ovary; Spindle Apparatus; Uterus; Valerates | 2015 |
Delayed Biotin Therapy in a Child with Atypical Profound Biotinidase Deficiency: Late Arrival of the Truth and a Lesson Worth Thinking.
Topics: Biotin; Biotinidase; Biotinidase Deficiency; Humans; Valerates | 2023 |