Compounds > bindarit
Page last updated: 2024-08-25

bindarit and indazoles

bindarit has been researched along with indazoles in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (11.76)18.2507
2000's10 (19.61)29.6817
2010's25 (49.02)24.3611
2020's10 (19.61)2.80

Authors

AuthorsStudies
Cheng, CY; Cioli, V; Guglielmotti, A; Luparini, MR; Saso, L; Silvestrini, B; Zwain, I1
Catanese, B; Ciarniello, MG; Cioli, V; Durando, L; Fava, L; Guglielmotti, A; Luparini, MR; Martinelli, B; Silvestrini, B1
Cheng, CY; Guglielmotti, A; Saso, L; Silvestrini, B; Zwain, I1
Benedetti, G; Bertani, T; Corna, D; Donadelli, R; Guglielmotti, A; Morigi, M; Pinza, M; Remuzzi, G; Zoja, C1
Braghiroli, L; Casini, ML; Grippa, E; Mattei, E; Mazzanti, G; Panzironi, C; Saso, L; Silvestrini, B; Valentini, G1
Bernasconi, S; Coletta, I; Fioretti, F; Guglielmotti, A; Mantovani, A; Milanese, C; Pinza, M; Polentarutti, N; Romano, M; Sironi, M; Sozzani, S; Vecchi, A; Vigini, C1
Appel, G; Radhakrishnan, J; Valeri, A; Zimmerman, R1
Aquilini, L; Coletta, I; D'Onofrio, E; Guglielmotti, A; Milanese, C; Pinza, M1
Bhatia, M; Chevali, L; Guglielmotti, A; Ramnath, RD1
Bravo, AI; Gazzaniga, S; Guglielmotti, A; Mantovani, A; Maschi, F; Mordoh, J; van Rooijen, N; Vecchi, A; Wainstok, R1
Bhatia, M; Guglielmotti, A; Ng, SW; Ramnath, RD1
Biondi, G; Fabbri, M; Guglielmotti, A; Locati, M; Mangano, G; Mantovani, A; Mirolo, M; Sironi, M; Vecchi, A1
Basta, F; Bhatia, M; Bovi, G; de Joannon, AC; Guglielmotti, A; Landolfi, C; Ramnath, RD1
Biondi, G; Grassia, G; Guglielmotti, A; Ialenti, A; Maddaluno, M; Maffia, P; Mangano, G1
Apicella, C; Guglielmotti, A; Mahalingam, S; Mangano, G; Rolph, MS; Rulli, NE; Suhrbier, A; Zaid, A1
Chade, AR; Daghini, E; Guglielmotti, A; Krier, JD; Lavi, R; Lerman, A; Lerman, LO; Zhu, XY1
Chen, JP; Ding, XL; Qiang, H; Wei, Q; Zhang, H; Zhang, HF; Zhou, GX; Zhu, XJ1
Baker, AH; Biondi, G; Colombo, A; Di Lauro, MV; Gordon, P; Grassia, G; Guglielmotti, A; Ialenti, A; Kennedy, S; Maddaluno, M; Maffia, P1
Biondi, G; Ble, A; Bombardieri, S; Di Loreto, G; Guglielmotti, A; Mosca, M; Remuzzi, G; Ruggenenti, P1
Anantapreecha, S; Guglielmotti, A; Mahalingam, S; Rolph, MS; Rulli, NE; Srikiatkhachorn, A1
Biondi, G; Guglielmotti, A; Mora, E; Sassone-Corsi, P1
Saccani, S1
Biondi, G; De Martino, D; Di Dato, V; Garrone, B; Guglielmotti, A; Liguori, L; Mangano, G; Marino, N; Navas, L; Spano, D; Vastolo, V; Zollo, M1
André, S; Bleich, D; Gabius, HJ; Huet, G; Kaltner, H; Kopitz, J; Ledeen, RW; Wu, G1
Cone, R; Ge, S; Guglielmotti, A; Keating, C; Pachter, JS; Paul, D; Shrestha, B1
Guglielmotti, A; Mangano, G; Musilli, C; Paccosi, S; Parenti, A1
Cicala, C; De Filippis, D; Di Lauro, MV; Grassia, G; Guglielmotti, A; Ialenti, A; Iuvone, T; Maddaluno, M; Maffia, P; Maione, F; Mascolo, N; Parisi, A1
Calissano, P; Ciotti, M; Di Matteo, A; Florenzano, F; Guglielmotti, A; Mercanti, D; Pachter, J; Passeri, PP; Possenti, R; Severini, C; Zona, C1
Davis, JM; Guglielmotti, A; McClellan, JL; Murphy, EA; Steiner, JL1
Chen, W; Foo, SS; Forwood, MR; Herrero, LJ; Hueston, L; Lulla, A; Mahalingam, S; Merits, A; Sims, NA; Taylor, A; Walsh, NC1
Buelli, S; Corna, D; Guglielmotti, A; Locatelli, M; Morigi, M; Perico, N; Pezzotta, A; Remuzzi, A; Remuzzi, G; Rottoli, D; Zanchi, C; Zoja, C1
Jiang, C; Li, J; Lian, M; Ma, C; Shen, T; Shi, J; Wang, N; Wei, L; Yu, X; Zhang, C; Zhao, X; Zhu, D1
Basavarajaiah, S; Calabresi, M; Colombo, A; Guglielmotti, A; Lettieri, C; Limbruno, U; Picchi, A; Pierucci, D; Prati, F; Sciahbasi, A; Valgimigli, M1
Allegra, M; Bozzi, Y; Caleo, M; Cerri, C; Genovesi, S; Guglielmotti, A; Perry, VH; Pistillo, F; Püntener, U1
Di Gennaro, P; Giachi, M; Guglielmotti, A; Paccosi, S; Parenti, A1
Chu, CR; Giori, NJ; Goodman, SB; Lepus, CM; Lingampalli, N; Oliviero, F; Punzi, L; Raghu, H; Robinson, WH; Sokolove, JB; Wang, Q; Wong, HH1
Furugen, A; Futagi, Y; Iseki, K; Kobayashi, M; Narumi, K1
Gao, C; Gao, H; Liu, S; Liu, W; Xing, D1
Frank, JA; Luo, J; Wang, H; Xu, M; Zhang, K1
Altschuler, F; Aranda, ML; Chianelli, MS; Dieguez, HH; Dorfman, D; González Fleitas, MF; Guerrieri, D; Keller Sarmiento, MI; Piñero, G; Rosenstein, RE; Sande, PH1
Alisi, MA; Angelucci, C; Assfalg, M; Caltagirone, C; Coletta, I; Dainese, E; Dufrusine, B; Maccarrone, M; Oddi, S; Polenzani, L; Sabatucci, A; Scipioni, L; Tortolani, D; Totaro, A1
Huang, X; Li, H; Li, L; Lou, W; Zhu, Y1
Li, X; Liu, F; Liu, J; Peng, C; Tang, Y; Xiang, T; Yin, L; Yuan, Y; Zhou, X1
Chen, J; Guan, M; Huang, X; Kuang, S; Lin, Z; Qin, W; Shen, Z; Xu, HHK; Zhang, M1
Lai, Q; Li, W; Lou, J; Peng, C; Teng, Z; Xu, C; Yin, L; Zhang, C; Zhou, X1
Chi, ZF; Kang, AL; Liu, YX; Nie, LH; Niu, CY; Wang, P; Wang, Q; Wei, D; Zhang, H; Zhang, LM; Zhao, M; Zhao, ZA; Zhao, ZG1
Furugen, A; Iseki, K; Kobayashi, M; Nadai, T; Narumi, K; Saito, Y1
Berta, T; Brown, FN; Campbell, K; Goto, J; Iwasawa, E; Kahn, F; Ladle, DR; Lee, SH; Mangano, FT; Shula, C1
Bai, XC; Hu, HL; Lai, PL; Wang, XJ; Yang, JC; Yuan, SG; Zhou, RP1
Cai, C; Kilari, S; Misra, S; Singh, AK1
Chao, W; Gu, CJ; Hadas, E; Kelschenbach, J; Kim, BH; Potash, MJ; Volsky, DJ1

Reviews

2 review(s) available for bindarit and indazoles

ArticleYear
Advances in the treatment of lupus nephritis.
    Annual review of medicine, 2001, Volume: 52

    Topics: Abatacept; Antigens, CD; Antigens, Differentiation; CTLA-4 Antigen; Cyclosporins; Humans; Immunoconjugates; Immunoglobulins, Intravenous; Immunosuppressive Agents; Indazoles; Linseed Oil; Lupus Nephritis; Morbidity; Mycophenolic Acid; Oligonucleotides; Plasmapheresis; Propionates; Treatment Outcome

2001
Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].
    Annals of the New York Academy of Sciences, 2012, Volume: 1253

    Topics: Animals; Anoikis; Cell Communication; G(M1) Ganglioside; Galectins; Glycoproteins; Humans; Indazoles; Mice; Models, Immunological; Morpholines; Neoplasms; Propionates; Signal Transduction; T-Lymphocytes

2012

Trials

2 trial(s) available for bindarit and indazoles

ArticleYear
Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis.
    American journal of nephrology, 2011, Volume: 34, Issue:4

    Topics: Acute Disease; Adult; Chemokine CCL2; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Indazoles; Kidney Diseases; Lupus Nephritis; Male; Middle Aged; Placebos; Propionates; Prospective Studies; Proteinuria; Remission Induction

2011
A double-blind randomised study to evaluate the efficacy and safety of bindarit in preventing coronary stent restenosis.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2016, Dec-10, Volume: 12, Issue:11

    Topics: Adolescent; Adult; Aged; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Double-Blind Method; Drug-Eluting Stents; Female; Humans; Indazoles; Male; Middle Aged; Percutaneous Coronary Intervention; Propionates; Treatment Outcome; Young Adult

2016

Other Studies

47 other study(ies) available for bindarit and indazoles

ArticleYear
Abnormal glycosylation of hemopexin in arthritic rats can be blocked by bindarit.
    The Journal of rheumatology, 1992, Volume: 19, Issue:12

    Topics: Acute-Phase Reaction; Amino Acid Sequence; Animals; Arthritis, Experimental; Blood Proteins; Chromatography, High Pressure Liquid; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Freund's Adjuvant; Glycosylation; Hemopexin; Immunoblotting; Indazoles; Molecular Sequence Data; Propionates; Rats; Rats, Sprague-Dawley; Staining and Labeling

1992
A new protein antidenaturant agent, bindarit, reduces secondary phase of adjuvant arthritis in rats.
    The Journal of rheumatology, 1992, Volume: 19, Issue:11

    Topics: Animals; Arthritis, Experimental; Blood Sedimentation; Cattle; Cytokines; Female; Hot Temperature; Indazoles; Indomethacin; Lipoxygenase; Male; Mice; Propionates; Prostaglandin-Endoperoxide Synthases; Protein Denaturation; Rats; Serum Albumin

1992
Chronic inflammatory response in the rat can be blocked by bindarit.
    Biochemistry and molecular biology international, 1993, Volume: 29, Issue:4

    Topics: Acute-Phase Proteins; alpha-Macroglobulins; Animals; Arthritis, Experimental; Clusterin; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Indazoles; Indomethacin; Male; Molecular Chaperones; Propionates; Proteins; Radioimmunoassay; Rats; Saposins; Serum Albumin

1993
Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease.
    Kidney international, 1998, Volume: 53, Issue:3

    Topics: Animals; Antibodies, Antinuclear; Blood Urea Nitrogen; Chemokine CCL2; Female; Humans; Indazoles; Inflammation Mediators; Kidney; Lupus Nephritis; Methylprednisolone; Mice; Mice, Inbred NZB; Propionates; Proteinuria; Rats

1998
Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: a new hypothesis for the mechanism of action of fish oil in rheumatic diseases.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Administration, Oral; Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Blood Proteins; Cattle; Charcoal; Chemical Fractionation; Dialysis; Fatty Acids; Fetal Blood; Fish Oils; Hot Temperature; Humans; Indazoles; Propionates; Protein Denaturation; Rats; Rats, Wistar; Rheumatic Diseases; Salts; Serum Albumin; Sodium Chloride; Tromethamine

1999
A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1.
    European cytokine network, 1999, Volume: 10, Issue:3

    Topics: Animals; Cell Line; Chemokine CCL2; Chemokines; Cytokines; Female; Humans; Indazoles; Mice; Monocytes; Propionates

1999
Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-alpha production.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:5

    Topics: Animals; Arthritis, Experimental; Cell Line; Chemokine CCL2; Cytokines; Hindlimb; Humans; Immunity; Indazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Osteoblasts; Ovalbumin; Propionates; Radiography; Rats; Tumor Necrosis Factor-alpha

2002
Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:6

    Topics: Acute Disease; Animals; Ceruletide; Chemokine CCL2; Disease Models, Animal; Indazoles; Inflammation; Mice; Necrosis; Pancreas; Pancreatitis; Propionates

2005
Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.
    The Journal of investigative dermatology, 2007, Volume: 127, Issue:8

    Topics: Animals; Cell Line, Tumor; Chemokine CCL2; Clodronic Acid; Humans; Indazoles; Liposomes; Macrophages; Male; Melanoma, Experimental; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Transplantation, Heterologous

2007
Role of MCP-1 in endotoxemia and sepsis.
    International immunopharmacology, 2008, Volume: 8, Issue:6

    Topics: Animals; Calmodulin; Chemokine CCL2; Endotoxemia; Indazoles; Lipopolysaccharides; Liver; Lung; Mice; Peritonitis; Peroxidase; Propionates; Sepsis

2008
Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.
    European cytokine network, 2008, Volume: 19, Issue:3

    Topics: Anti-Inflammatory Agents; Cells, Cultured; Chemokine CCL2; Chemokine CCL7; Chemokine CCL8; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Humans; Indazoles; Monocyte Chemoattractant Proteins; Monocytes; Propionates; Reverse Transcriptase Polymerase Chain Reaction

2008
Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:10

    Topics: Animals; Cells, Cultured; Chemokine CCL2; Colitis; Disease Progression; Epithelial Cells; Female; Humans; Indazoles; Interferon-gamma; Mice; Mice, Inbred BALB C; Propionates; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

2008
The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice.
    Cardiovascular research, 2009, Dec-01, Volume: 84, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Carotid Arteries; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Female; Hyperlipidemias; Indazoles; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Propionates; Rats; Rats, Wistar

2009
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins.
    Arthritis and rheumatism, 2009, Volume: 60, Issue:8

    Topics: Alphavirus; Alphavirus Infections; Animals; Antirheumatic Agents; Arthritis, Experimental; Cell Line; Disease Models, Animal; Down-Regulation; Humans; Indazoles; Macrophages; Mice; Mice, Inbred C57BL; Monocyte Chemoattractant Proteins; Muscle, Skeletal; Myositis; Propionates; RNA, Messenger

2009
The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension.
    Journal of hypertension, 2009, Volume: 27, Issue:10

    Topics: Animals; Chemokine CCL2; Disease Models, Animal; Fibrosis; Hypertension, Renovascular; Indazoles; Kidney Tubules; NADPH Oxidases; Nephritis; NF-kappa B; Propionates; Receptors, CCR2; Renal Artery Obstruction; Renal Circulation; Sus scrofa; Up-Regulation; Urothelium

2009
Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2010, Volume: 9, Issue:2

    Topics: Acute Disease; Amylases; Animals; Chemokine CCL2; Immunohistochemistry; Indazoles; Male; Pancreas; Pancreatitis; Propionates; Rats; Rats, Sprague-Dawley; RNA, Messenger

2010
Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:11

    Topics: Administration, Oral; Animals; Cell Proliferation; Coronary Stenosis; Coronary Vessels; Indazoles; Male; Models, Animal; Monocyte Chemoattractant Proteins; Muscle, Smooth, Vascular; Neointima; Propionates; Stents; Swine; Treatment Outcome

2011
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis.
    The Journal of infectious diseases, 2011, Oct-01, Volume: 204, Issue:7

    Topics: Alphavirus Infections; Animals; Arthritis, Infectious; Chemokine CCL2; Chikungunya Fever; Chikungunya virus; Humans; Indazoles; Interferon-gamma; Mice; Mice, Inbred C57BL; Models, Animal; Myositis; Propionates; Tumor Necrosis Factor-alpha; Viral Load

2011
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
    Cell cycle (Georgetown, Tex.), 2012, Jan-01, Volume: 11, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Base Sequence; Cells, Cultured; Chemokine CCL2; Down-Regulation; I-kappa B Proteins; Indazoles; Interleukin-12 Subunit p40; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Molecular Sequence Data; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; Propionates; Signal Transduction; Transcription Factor RelA

2012
All p65-containing dimers are not equal.
    Cell cycle (Georgetown, Tex.), 2012, Feb-15, Volume: 11, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Indazoles; NF-kappa B; Propionates

2012
Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models.
    Clinical & experimental metastasis, 2012, Volume: 29, Issue:6

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CCL2; Female; Humans; Indazoles; Macrophages; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; NF-kappa B; Propionates; Prostatic Neoplasms; Signal Transduction

2012
The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis.
    Journal of neuroinflammation, 2012, Jul-12, Volume: 9

    Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chemokine CCL2; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental; Female; Indazoles; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Propionates; Spinal Cord

2012
The monocyte chemotactic protein synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling.
    Pharmacological research, 2012, Volume: 66, Issue:6

    Topics: Blotting, Western; Cell Culture Techniques; Cell Line; Cell Proliferation; Chemokine CCL2; Extracellular Matrix; Humans; Indazoles; Mesangial Cells; Propionates; Reverse Transcriptase Polymerase Chain Reaction

2012
Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Actins; Animals; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cell Movement; Cell Proliferation; Coronary Vessels; Gene Expression; Humans; Indazoles; Microfilament Proteins; Monocyte Chemoattractant Proteins; Myocytes, Smooth Muscle; Myosin Heavy Chains; Neointima; Propionates; Rats

2012
Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid-β-induced toxicity.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 38, Issue:2

    Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Cell Survival; Cerebral Cortex; Chemokine CCL2; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Indazoles; Neuroglia; Neurons; Neuroprotective Agents; Peptide Fragments; Pregnancy; Propionates; Rats; Rats, Wistar

2014
Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer.
    Cytokine, 2014, Volume: 66, Issue:1

    Topics: Animals; Antigens, Polyomavirus Transforming; Biomarkers; Body Weight; Carcinogenesis; Chemokine CCL2; Disease Models, Animal; Feeding Behavior; Female; Gene Expression Regulation; Indazoles; Inflammation Mediators; Interleukin-6; Macrophages; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Mice, Transgenic; Organ Size; Propionates; RNA, Messenger; Spleen; Tumor Burden; Tumor Necrosis Factor-alpha

2014
Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection.
    Journal of virology, 2015, Volume: 89, Issue:1

    Topics: Adult; Aged; Animals; Bone Density Conservation Agents; Bone Resorption; Chemokine CCL2; Chikungunya Fever; Disease Models, Animal; Female; Humans; Indazoles; Male; Mice, Inbred C57BL; Middle Aged; Propionates

2015
Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic kidney disease.
    Nephron, 2015, Volume: 129, Issue:1

    Topics: Animals; Chemokine CCL2; Disease Models, Animal; In Vitro Techniques; Indazoles; Macrophages; Male; Monocytes; Podocytes; Polycystic Kidney, Autosomal Dominant; Propionates; Proteinuria; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; RNA, Messenger

2015
15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Sep-01, Volume: 309, Issue:5

    Topics: Animals; Arachidonate 15-Lipoxygenase; Blood Platelets; Cells, Cultured; Chemokine CCL2; Cytokines; Humans; Hydroxyeicosatetraenoic Acids; Hypertension, Pulmonary; Hypoxia; Indazoles; Lipoxygenase Inhibitors; Male; Masoprocol; Platelet Activation; Propionates; Pulmonary Artery; Random Allocation; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Signal Transduction; Thrombosis; Vascular Resistance

2015
The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-30, Volume: 36, Issue:13

    Topics: Animals; Antibodies; Benzoxazines; Chemokine CCL2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Inflammation; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Piperidines; Propionates; Receptors, CCR2; RNA, Messenger; Signal Transduction; Up-Regulation

2016
The chemokine (C-C motif) ligand protein synthesis inhibitor bindarit prevents cytoskeletal rearrangement and contraction of human mesangial cells.
    Cytokine, 2016, Volume: 85

    Topics: Actins; Angiotensin II; Anti-Inflammatory Agents; Cells, Cultured; Chemokines; Cytoskeleton; Endothelin-1; Glomerular Mesangium; Humans; Indazoles; Ligands; Mesangial Cells; Propionates; Protein Synthesis Inhibitors; Transforming Growth Factor beta; Up-Regulation

2016
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:5

    Topics: Animals; Cartilage, Articular; Chemokine CCL2; Chemokine CCL5; Chemokines; Chemotaxis; Fibroblasts; Gene Expression; Humans; Indazoles; Leukocyte Count; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Osteoarthritis; Propionates; Receptors, CCR2; Receptors, CCR5; RNA, Messenger; Signal Transduction; Synovial Fluid

2017
Identification of a selective inhibitor of human monocarboxylate transporter 4.
    Biochemical and biophysical research communications, 2018, 01-01, Volume: 495, Issue:1

    Topics: Animals; Biological Transport; Cells, Cultured; Drug Discovery; Female; Fibric Acids; Humans; Indazoles; Isobutyrates; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oocytes; Propionates; Protein Isoforms; Xenopus laevis

2018
Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer.
    Archivum immunologiae et therapiae experimentalis, 2018, Volume: 66, Issue:3

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinogenesis; Cell Line, Tumor; Chemokine CCL2; Disease Models, Animal; Humans; I-kappa B Kinase; Indazoles; Inflammation; Male; Mice; Mice, Nude; Myeloid Cells; Neoplasms, Experimental; Propionates; Signal Transduction; Tumor Burden

2018
Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain.
    Journal of neuroinflammation, 2018, Jul-05, Volume: 15, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Benzoxazines; Brain; Caspase 3; Cells, Cultured; Central Nervous System Depressants; Chemokine CCL2; Disease Models, Animal; Encephalitis; Ethanol; Gene Expression Regulation, Developmental; Indazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Propionates; Receptors, CCR2; Signal Transduction; Spiro Compounds

2018
Critical Role of Monocyte Recruitment in Optic Nerve Damage Induced by Experimental Optic Neuritis.
    Molecular neurobiology, 2019, Volume: 56, Issue:11

    Topics: Animals; Blood-Brain Barrier; Chemokine CCL2; Indazoles; Lipopolysaccharides; Male; Monocytes; Optic Nerve; Optic Neuritis; Permeability; Propionates; Rats, Wistar; Recombinant Proteins; Tissue Plasminogen Activator

2019
The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells.
    Scientific reports, 2019, 10-22, Volume: 9, Issue:1

    Topics: Active Transport, Cell Nucleus; Anti-Inflammatory Agents; Cell Line; Cell Nucleus; Chemokine CCL2; Fatty Acid-Binding Proteins; Humans; Immunologic Factors; Indazoles; Interleukin-8; Lipopolysaccharides; Models, Biological; Monocytes; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Propionates; Protein Binding; Up-Regulation

2019
Upregulated C-C Motif Chemokine Ligand 2 Promotes Ischemic Stroke via Chemokine Signaling Pathway.
    Annals of vascular surgery, 2020, Volume: 68

    Topics: Animals; Brain; Chemokine CCL2; Disease Models, Animal; Humans; Indazoles; Infarction, Middle Cerebral Artery; Locomotion; Male; Neuroprotective Agents; Propionates; Protein Interaction Maps; Rats, Sprague-Dawley; Signal Transduction; Transcriptome; Up-Regulation

2020
Biomimetic oral targeted delivery of bindarit for immunotherapy of atherosclerosis.
    Biomaterials science, 2020, Jul-07, Volume: 8, Issue:13

    Topics: Administration, Oral; Animals; Biocompatible Materials; Biomimetics; Carbocyanines; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Drug Delivery Systems; Immunotherapy; Indazoles; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; Propionates; RAW 264.7 Cells

2020
Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.
    Cellular & molecular immunology, 2021, Volume: 18, Issue:9

    Topics: Chemokine CCL2; Diabetes Mellitus; Humans; Indazoles; Macrophages; Monocytes; Periodontitis; Propionates

2021
Prevention of Obesity Related Diseases through Laminarin-induced targeted delivery of Bindarit.
    Theranostics, 2020, Volume: 10, Issue:21

    Topics: Adipose Tissue; Animals; Atherosclerosis; Computer Simulation; Diet, High-Fat; Fatty Liver; Glucans; Humans; Indazoles; Inflammation; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Monocytes; Nanoparticles; Obesity; Plaque, Atherosclerotic; Propionates

2020
Transcriptome Analysis Revealed Inflammation Is Involved in the Impairment of Human Umbilical Vein Endothelial Cells Induced by Post-hemorrhagic Shock Mesenteric Lymph.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Gene Expression Profiling; Gene Regulatory Networks; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Inflammation; Lymph; Lymphatic System; Male; Mesentery; Propionates; Rats, Wistar; Shock, Hemorrhagic; Signal Transduction; Transcriptome

2020
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; MCF-7 Cells; Monocarboxylic Acid Transporters; Muscle Proteins; Propionates; Receptors, Estrogen; Tamoxifen

2021
The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 03-02, Volume: 42, Issue:9

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Disease Models, Animal; Female; Humans; Hydrocephalus; Indazoles; Mice; Microglia; Pregnancy; Propionates

2022
Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF-κB Signaling Pathway.
    Orthopaedic surgery, 2022, Volume: 14, Issue:6

    Topics: Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Differentiation; Chemokine CCL2; Chemokine CCL7; Cytokines; Female; Humans; I-kappa B Kinase; Indazoles; Mice; NF-kappa B; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Propionates; RNA, Messenger; Signal Transduction; X-Ray Microtomography

2022
Bindarit encapsulated nanoparticles prevent venous neointimal hyperplasia and restenosis in a murine angioplasty model.
    Translational research : the journal of laboratory and clinical medicine, 2022, Volume: 248

    Topics: Angioplasty; Animals; Arteriovenous Fistula; Chromatography, Liquid; Constriction, Pathologic; Disease Models, Animal; Hyperplasia; Indazoles; Mice; Nanoparticles; Neointima; Propionates; Renal Dialysis; Tandem Mass Spectrometry

2022
CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice.
    Scientific reports, 2023, 04-21, Volume: 13, Issue:1

    Topics: AIDS Dementia Complex; Animals; Chemokine CCL2; Cognition; Disease Models, Animal; HIV Infections; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Receptors, CCR2

2023