bimatoprost and prednisolone-acetate

To report a case of herpes simplex virus reactivation after starting bimatoprost treatment for glaucoma.. Interventional case report.. A 66-year-old woman had a herpes simplex keratouveitis reactivation that occurred within 1 month after starting bimatoprost. The herpes simplex had been inactive for more than 10 years.. Bimatoprost and prednisolone acetate 0.12% were discontinued; oral acyclovir, ofloxacin, and betaxolol 0.25% were initiated. Two weeks later, prednisolone acetate 1% was added. The reactivation resolved, and 1 month later, the best corrected visual acuity improved to 20/40.. Caution should be used in prescribing bimatoprost for patients with a history of herpes simplex virus keratitis.

Topics: Acyclovir; Aged; Amides; Anti-Infective Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Antiviral Agents; Betaxolol; Bimatoprost; Cloprostenol; Drug Therapy, Combination; Female; Glaucoma; Herpesvirus 1, Human; Humans; Intraocular Pressure; Keratitis, Herpetic; Lipids; Ofloxacin; Prednisolone; Virus Activation; Visual Acuity