bimakalim has been researched along with dihydropyridines in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.55) | 18.7374 |
| 1990's | 47 (71.21) | 18.2507 |
| 2000's | 15 (22.73) | 29.6817 |
| 2010's | 1 (1.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Auch-Schwelk, W; Bossaller, C; Catadelgirmen, G; Ennker, J; Fleck, E; Graf, K; Gräfe, M | 1 |
| Auchampach, JA; Gross, GJ; Maruyama, M; Pieper, GM; Warltier, DC | 1 |
| Auchampach, JA; Gross, GJ; Grover, GJ | 1 |
| Baas, NR; van der Giessen, WJ; van Woerkens, LJ; Verdouw, PD | 1 |
| Armstrong, JM; Barras, M; Hicks, PE; Lawson, K; Martin, DJ; Zazzi-Sudriez, E | 1 |
| Hertel, RF | 1 |
| Findlay, I | 3 |
| Ecault, E; Faivre, JF; Findlay, I; Sauviat, MP | 1 |
| Bertrand, JP; Gautier, P; Guiraudou, P | 1 |
| Diekmann, HW; Duncker, DJ; Gho, BC; Sassen, LM; Verdouw, PD | 1 |
| Haeusler, G | 1 |
| Findlay, I; Sauviat, MP | 1 |
| Franke, C; Hatt, H; Quasthoff, S; Richter-Turtur, M | 1 |
| Faivre, JF; Findlay, I | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Spittelmeister, W; Spuler, A | 1 |
| Bergmann, R; Gericke, R | 1 |
| Doussau, MP; Gautier, P; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Doussau, MP; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Coraboeuf, E; Deroubaix, E; Findlay, I; Guiraudou, P | 1 |
| De Peyer, JE; Gericke, R; Häusler, G; Lues, I | 1 |
| Buchner-Moell, D; Lahiri, A; Raftery, E; Senior, R | 1 |
| Auchampach, JA; Gross, GJ | 2 |
| Faurschou, P; Franke, B; Mikkelsen, KL; Steffensen, I | 1 |
| Gross, GJ; Mizumura, T; Nithipatikom, K | 1 |
| Moré, MT; Sauviat, MP; Verbist, JF | 1 |
| Glusa, E; Müller-Schweinitzer, E; Schilling, A | 1 |
| Parsons, AA; Schilling, L; Wahl, M | 1 |
| Grover, GJ | 1 |
| Becker, KH; Häusler, G; Lues, I; Rohmann, S; Schelling, P; Soei, LK; Verdouw, PD; Weygandt, H | 1 |
| Gross, GJ; Yao, Z | 2 |
| Auchampach, JA; Gross, GJ; Maruyama, M | 1 |
| Cavero, I; Premmereur, J | 1 |
| Boban, M; Bosnjak, ZJ; Gross, GJ; Kampine, JP; Pieper, GM; Stowe, DF | 1 |
| Fujita, S; Graf, BM; Gross, GJ; Stowe, DF | 1 |
| Belz, GG; De Mey, C; Erb, K; Schroeter, V | 1 |
| Katoch, SS; Pfitzer, G; Rüegg, JC | 1 |
| Gross, GJ; Grover, GJ; Mei, DA; Sleph, PG | 1 |
| Gross, GJ; Mei, DA; Mizumura, T; Yao, Z | 1 |
| Baker, JE; Curry, BD; Gross, GJ; Olinger, GN | 1 |
| Krieglstein, J; Peruche, B; Prehn, JH; Wind, T | 1 |
| Bosnjak, ZJ; Contney, SJ; Lathrop, DA; Stowe, DF | 1 |
| Gross, GJ; Lasley, RD; Mei, DA; Nithipatikom, K | 1 |
| Bosnjak, ZJ; Fujita, S; Roerig, DL; Stowe, DF | 1 |
| Criniti, A; Dawodu, AA; Ducouret, P; La Francesca, S; Macrina, F; Monti, F; Picard, S; Puddu, PE; Rouet, R; Ruvolo, G; Tonelli, E | 1 |
| Criniti, A; del Monte, F; Ducouret, P; Iwashiro, K; Monti, F; Papalia, U; Picard, S; Puddu, PE; Rouet, R; Ruvolo, G; Tonelli, E | 1 |
| Criniti, A; Ducouret, P; Flais, F; Gérard, JL; Monti, F; Picard, S; Puddu, PE; Rouet, R | 1 |
| Campa, PP; Criniti, A; Iwashiro, K; La Francesca, S; Marino, B; Monti, F; Papalia, U; Picard, S; Puddu, PE; Ruvolo, G | 1 |
| Buchheit, KH; Hofmann, A; Manley, P; Pfannkuche, HJ; Quast, U | 1 |
| Hamm, C; Mitrovic, V; Oehm, E; Pitschner, H; Thormann, J | 1 |
| Baker, JE; Eells, JT; Gross, GJ; Henry, MM | 1 |
| Campbell, WB; Hillard, CJ; Kurian, J; Li, P; Pratt, PF | 1 |
| Coetzee, WA; Holmes, D; Holmes, TC; Kaneko, M; Manaris, T; Nakamura, TY; Nitabach, MN; Porter, LM; Pountney, DJ; Rosner, E; Sun, ZQ | 1 |
| Das, B; Karanth, KS; Sarkar, C | 1 |
| Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK | 1 |
| Bosnjak, ZJ; Fujimoto, K; Kwok, WM | 1 |
| Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Stowe, DF | 1 |
| Burian, M; Mitrovic, V; Petkovic, D; Piske, M | 1 |
| Beier, N; El Schultz, J; Gross, GJ; Gumina, RJ; Moore, J; Schelling, P | 1 |
| Duncker, DJ; Hoogteijling, BA; Houweling, B; Merkus, D; Sorop, O | 1 |
| Lemoine, H; Quast, U; Russ, U; Salamon, E; Stephan, D; Weber, H | 1 |
| Aidonidis, I; Lymberi, M; Molyvdas, PA; Poyatzi, A; Stamatiou, G; Stamatoyannis, N | 1 |
| Alexandre, J; Beygui, F; Guinamard, R; Hof, T; Manrique, A; Milliez, P; Puddu, PE; Rouet, R; Sallé, L; Simard, C | 1 |
2 review(s) available for bimakalim and dihydropyridines
| Article | Year |
|---|---|
K(+)-channel openers: new antihypertensive drugs?
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Hemodynamics; Humans; Hypertension; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1990 |
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disease Models, Animal; Dogs; Guanidines; Guinea Pigs; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rats; Vasodilator Agents | 1994 |
5 trial(s) available for bimakalim and dihydropyridines
| Article | Year |
|---|---|
Potent hemodynamic effects of bimakalim, a new potassium channel opener, in humans.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Benzopyrans; Dihydropyridines; Double-Blind Method; Echocardiography; Hemodynamics; Humans; Male; Middle Aged; Vasodilator Agents | 1993 |
The lack of bronchodilator effect and the short-term safety of cumulative single doses of an inhaled potassium channel opener (bimakalim) in adult patients with mild to moderate bronchial asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Antihypertensive Agents; Asthma; Benzopyrans; Bronchi; Bronchodilator Agents; Dihydropyridines; Double-Blind Method; Female; Humans; Kinetics; Male; Middle Aged; Potassium Channels | 1994 |
Differentiation of inodilatory responses by non-invasive measures of cardiovascular performance in healthy man.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Benzopyrans; Cardiotonic Agents; Celiprolol; Cross-Over Studies; Cyclic Nucleotide Phosphodiesterases, Type 3; Dihydropyridines; Dose-Response Relationship, Drug; Double-Blind Method; Hemodynamics; Humans; Isoproterenol; Male; Monitoring, Physiologic | 1996 |
Potassium channel openers and blockers in coronary artery disease. Comparison to betablockers and calcium antagonists.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Angina Pectoris; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Cardiotonic Agents; Coronary Disease; Cyclopropanes; Dihydropyridines; Electrocardiography; Exercise Test; Gallopamil; Hemodynamics; Humans; Middle Aged; Myocardium; Oxygen Consumption; Potassium Channel Blockers; Potassium Channels; Propanolamines; Time Factors; Vasodilator Agents | 2000 |
Lack of anti-ischemic efficacy of the potassium channel opener bimakalim in patients with stable angina pectoris.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Benzopyrans; Blood Pressure; Dihydropyridines; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardium; Oxygen Consumption; Potassium Channels; Pulmonary Wedge Pressure; Stroke Volume; Vascular Resistance; Vasodilation | 2004 |
59 other study(ies) available for bimakalim and dihydropyridines
| Article | Year |
|---|---|
Relaxation of human coronary artery and arteria mammaria by K(+)-channel openers.
Topics: Benzopyrans; Coronary Vessels; Dihydropyridines; Humans; In Vitro Techniques; Mammary Arteries; Niacinamide; Nicorandil; Potassium Channels; Vasodilation; Vasodilator Agents | 1992 |
Cardioprotective effects of nicorandil.
Topics: Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophils; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion; Superoxides | 1992 |
Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Blood Glucose; Blood Pressure; Coronary Circulation; Coronary Vessels; Decanoic Acids; Dihydropyridines; Dogs; Glyburide; Heart Rate; Hydroxy Acids; Myocardial Ischemia; Myocardium; Potassium; Potassium Channels; Vasodilator Agents | 1992 |
Cardiovascular effects of the novel potassium channel opener bimakalim in conscious pigs after myocardial infarction: a comparative study with nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Dihydropyridines; Hemodynamics; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Propranolol; Swine; Vasodilation; Ventricular Function, Left | 1992 |
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Guanidines; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1992 |
Potassium channel activation improves blood flow pattern of conscious rats in cutaneous microcirculation.
Topics: Animals; Benzopyrans; Blood Pressure; Dihydropyridines; Dose-Response Relationship, Drug; Ear, External; Female; Male; Microcirculation; Potassium Channels; Rats; Rats, Inbred WKY; Regional Blood Flow; Skin; Vasodilator Agents | 1992 |
Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; Glyburide; Guinea Pigs; Heart Ventricles; Muscle, Smooth, Vascular; Potassium Channels; Tolbutamide; Vasodilator Agents | 1992 |
Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; Drug Interactions; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Tolbutamide; Vasodilator Agents | 1992 |
Activation of ATP-sensitive K channels by a K channel opener (SR 44866) and the effect upon electrical and mechanical activity of frog skeletal muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Glyburide; Membrane Potentials; Muscle Contraction; Muscles; Potassium Channels; Rana esculenta; Sodium Channels; Tetrodotoxin | 1991 |
Effects of SR 44866, a potassium channel opener, on action potentials of rabbit, guinea pig, and human heart fibers.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; Heart Atria; Humans; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Papillary Muscles; Potassium Channels; Purkinje Fibers; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Haemodynamic profile of the potassium channel activator EMD 52692 in anaesthetized pigs.
Topics: Animals; Benzopyrans; Cardiac Output; Coronary Circulation; Dihydropyridines; Female; Hemodynamics; Infusions, Intravenous; Male; Potassium Channels; Swine; Vasodilator Agents | 1990 |
[Decrease of the contraction force of skeletal muscle in mammals by the potassium channel activator, SR 44866].
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Binding Sites; Binding, Competitive; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Male; Mammals; Mice; Muscle Contraction; Potassium Channels; Temperature | 1990 |
Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
Topics: Adenosine Triphosphate; Benzopyrans; Cromakalim; Dihydropyridines; Electrophysiology; Glyburide; Humans; Muscles; Picolines; Potassium Channels; Pyrans; Pyrroles | 1990 |
Action potential duration and activation of ATP-sensitive potassium current in isolated guinea-pig ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Disease; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Potassium; Potassium Channels | 1990 |
K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.
Topics: Benzopyrans; Cell Membrane Permeability; Cromakalim; Dihydropyridines; Humans; In Vitro Techniques; Microelectrodes; Muscle Contraction; Muscles; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Chemical Phenomena; Chemistry; Dihydropyridines; Potassium Channels; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1990 |
Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.
Topics: Animals; Benzopyrans; Brimonidine Tartrate; Cromakalim; Decerebrate State; Dihydropyridines; Heart Rate; Hemodynamics; Imidazoles; Male; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Inbred SHR; Regional Blood Flow; Sympathetic Nervous System; Vascular Resistance | 1990 |
[Potassium agonists: regional vasodilator profile in rats].
Topics: Animals; Benzopyrans; Cromakalim; Dihydropyridines; Hemodynamics; Male; Nicardipine; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Effects of activation of ATP-sensitive K+ channels in mammalian ventricular myocytes.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; Guinea Pigs; Heart; Heart Ventricles; Male; Myocardium; Potassium Channels; Vasodilator Agents | 1989 |
Characterization of a novel K+ channel activator, EMD 52962, in electrophysiological and pharmacological experiments.
Topics: Animals; Benzopyrans; Dihydropyridines; Electrophysiology; In Vitro Techniques; Muscle, Smooth, Vascular; Potassium Channels; Vasodilator Agents | 1989 |
Reduction in myocardial infarct size by the new potassium channel opener bimakalim.
Topics: Animals; Benzopyrans; Cell Movement; Coronary Circulation; Dihydropyridines; Dogs; Female; Hemodynamics; Male; Myocardial Infarction; Neutrophils; Potassium Channels; Regional Blood Flow; Vasodilator Agents | 1994 |
Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Chromatography, High Pressure Liquid; Collateral Circulation; Coronary Circulation; Dihydropyridines; Dogs; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Neutrophils; Peroxidase; Potassium Channels; Time Factors; Vasodilator Agents | 1995 |
Pachymatisma johnstonii extract opens ATP-sensitive potassium channels in cardiac myocytes of the frog heart.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Myocardium; Porifera; Potassium Channels; Rana esculenta | 1994 |
Nature of the vehicle solution for cryopreservation of human peripheral veins: preservation of reactivity to pharmacological stimuli.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Benzopyrans; Cryopreservation; Cryoprotective Agents; Culture Media; Dihydropyridines; Dimethyl Sulfoxide; Endothelium, Vascular; Evaluation Studies as Topic; Glucose; Humans; In Vitro Techniques; Norepinephrine; Papaverine; Prostaglandin Endoperoxides, Synthetic; Saphenous Vein; Serotonin; Sucrose; Thromboxane A2; Tromethamine; Vasoconstriction; Vasodilation; Veins | 1995 |
Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Dihydropyridines; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Uridine Triphosphate; Vasodilator Agents | 1995 |
Effect of bimakalim (EMD 52692), an opener of ATP sensitive potassium channels, on infarct size, coronary blood flow, regional wall function, and oxygen consumption in swine.
Topics: Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Heart; Hydralazine; Ion Channel Gating; Myocardial Infarction; Oxygen Consumption; Potassium Channels; Swine; Vasodilator Agents | 1994 |
Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Dihydropyridines; Dogs; Female; Heart Rate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Potassium Channels; Time Factors; Vasodilator Agents | 1994 |
Cardioprotective actions of potassium channel openers.
Topics: Animals; Benzopyrans; Dihydropyridines; Disease Models, Animal; Dogs; Female; Glyburide; Male; Myocardial Infarction; Myocardial Stunning; Picolines; Potassium Channel Blockers; Potassium Channels; Pyrans; Vasodilator Agents | 1994 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs.
Topics: Action Potentials; Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Female; Heart; Male; Myocardial Infarction; Myocardial Ischemia; Potassium Channels; Vasodilator Agents | 1994 |
Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Dihydropyridines; Dinitrophenols; Glyburide; Heart; Membrane Potentials; Myocardial Contraction; Myocardium; Potassium Channels; Rats; Sensitivity and Specificity; Stress, Physiological; Sulfonylurea Compounds; Tolbutamide | 1993 |
Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channels; Pyrans; Vasodilator Agents | 1993 |
Potassium channel openers attenuate atrioventricular block by bupivacaine in isolated hearts.
Topics: Animals; Benzopyrans; Bupivacaine; Dihydropyridines; Glyburide; Guanidines; Guinea Pigs; Heart Block; In Vitro Techniques; Pinacidil; Potassium Channels; Vasodilator Agents | 1993 |
One-day cold perfusion of bimakalim and butanedione monoxime restores ex situ cardiac function.
Topics: Animals; Benzopyrans; Cold Temperature; Coronary Circulation; Diacetyl; Dihydropyridines; Drug Administration Schedule; Drug Combinations; Glyburide; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Oxygen Consumption; Perfusion; Pressure; Time Factors; Vasodilator Agents; Ventricular Function, Left | 1996 |
Differential effects of a K+ channel agonist and Ca2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle.
Topics: Animals; Benzopyrans; Dihydropyridines; Endothelin-1; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Nitrendipine; Sheep; Trachea; Verapamil | 1997 |
Adenosine A1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Dogs; Heart Rate; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Regression Analysis; Ventricular Function, Left; Xanthines | 1997 |
KATP channels and memory of ischemic preconditioning in dogs: synergism between adenosine and KATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Drug Combinations; Female; Gases; Glyburide; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Potassium Channels | 1997 |
Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzopyrans; Coronary Circulation; Dihydropyridines; Glyburide; Heart; Heart Rate; Hemodynamics; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Lactates; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Potassium Channels; Rabbits; Ventricular Function, Left; Ventricular Function, Right | 1997 |
Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Survival; Chick Embryo; Dihydropyridines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Neurons; Neuroprotective Agents; Potassium Channels; Pyridazines; Sodium Cyanide | 1997 |
Reversal of hypothermia-induced action potential lengthening by the KATP channel agonist bimakalim in isolated guinea pig ventricular muscle.
Topics: Action Potentials; Animals; Benzopyrans; Body Temperature Regulation; Dihydropyridines; Electric Stimulation; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Papillary Muscles; Potassium Channels; Temperature | 1998 |
Myocardial preconditioning produced by ischemia, hypoxia, and a KATP channel opener: effects on interstitial adenosine in dogs.
Topics: Adenine Nucleotides; Adenosine; Animals; Benzopyrans; Dihydropyridines; Dogs; Extracellular Space; Hemodynamics; Hypoxanthine; Hypoxia; Inosine; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Potassium Channels; Uric Acid; Xanthine | 1998 |
Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts.
Topics: Animals; Benzopyrans; Bradykinin; Cholinesterase Reactivators; Citrulline; Diacetyl; Dihydropyridines; Dose-Response Relationship, Drug; Electrodes; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Heart; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxygen Consumption; Perfusion; Phosphodiesterase Inhibitors; Pressure; Purinones; Regional Blood Flow; Serotonin; Vasodilator Agents | 1998 |
Effects of bimakalim on human cardiac action potentials: comparison with guinea pig and nicorandil and use-dependent study.
Topics: Action Potentials; Animals; Benzopyrans; Cardiotonic Agents; Dihydropyridines; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Heart Atria; Heart Ventricles; Humans; In Vitro Techniques; Male; Nicorandil | 1999 |
Protection of human myocardium in vitro by K(ATP) activation with low concentrations of bimakalim.
Topics: Adenosine Triphosphate; Adult; Benzopyrans; Dihydropyridines; Dobutamine; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; Heart Atria; Humans; Hypoxia; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Myocardial Contraction; Myocardium; Oxygen; Potassium Channels; Time Factors | 1999 |
KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; ATP-Binding Cassette Transporters; Benzopyrans; Dihydropyridines; Electrophysiology; Female; Glyburide; Guinea Pigs; Heart Conduction System; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying | 1999 |
Adenosine triphosphate-dependent potassium channel modulation and cardioplegia-induced protection of human atrial muscle in an in vitro model of myocardial stunning.
Topics: Adenosine Triphosphate; Adult; Aged; Atrial Function, Right; Benzopyrans; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Cardiotonic Agents; Cell Hypoxia; Dihydropyridines; Dobutamine; Female; Glyburide; Heart Arrest, Induced; Humans; In Vitro Techniques; Magnesium; Male; Middle Aged; Myocardial Contraction; Myocardial Stunning; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Sodium Chloride | 2000 |
Atypical effect of minoxidil sulphate on guinea pig airways.
Topics: Adenosine Triphosphate; Animals; Antigen-Antibody Complex; Benzopyrans; Blood Pressure; Bronchial Hyperreactivity; Dihydropyridines; Female; Glyburide; Guinea Pigs; Heart Rate; Histamine; In Vitro Techniques; Male; Minoxidil; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Portal Vein; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Trachea | 2000 |
Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cell Hypoxia; Chronic Disease; Cytoprotection; Decanoic Acids; Dihydropyridines; Energy Metabolism; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; In Vitro Techniques; Membrane Potentials; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Potassium Channel Blockers; Potassium Channels; Rabbits | 2000 |
Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Benzopyrans; Biological Factors; Bradykinin; Cardiotonic Agents; Cattle; Coronary Vessels; Dihydropyridines; Electrophysiology; Endothelium, Vascular; Membrane Potentials; Muscle, Smooth, Vascular; Nitroprusside; Ouabain; Peptides; Potassium; Potassium Channels; Tritium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Is the molecular composition of K(ATP) channels more complex than originally thought?
Topics: Adenosine Triphosphate; Animals; Antibodies; Benzopyrans; Cells, Cultured; Dihydropyridines; Electrophysiology; Genetic Vectors; Glyburide; Humans; Hypoglycemic Agents; Mice; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Protein Subunits; RNA, Messenger; Signal Transduction; Transfection | 2001 |
Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Gas Analysis; Coronary Disease; Decanoic Acids; Dihydropyridines; Drug Combinations; Hemodynamics; Hydroxy Acids; Male; Myocardial Ischemia; Nicorandil; Potassium Channels; Rabbits; Reperfusion Injury; Survival Rate | 2001 |
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
Isoflurane-induced facilitation of the cardiac sarcolemmal K(ATP) channel.
Topics: 2,4-Dinitrophenol; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Dihydropyridines; Guinea Pigs; Heart; Isoflurane; Potassium Channels; Protein Kinase C | 2002 |
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Lidocaine; Myocardial Ischemia; Myocardial Reperfusion Injury; Nifedipine; Osmolar Concentration; Pressure; Ventricular Function, Left | 2004 |
Cardioprotective-mimetics reduce myocardial infarct size in animals resistant to ischemic preconditioning.
Topics: Animals; Benzamides; Benzopyrans; Cardiotonic Agents; Dihydropyridines; Disease Models, Animal; Dogs; Heart; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Potassium Channels; Pyrroles; Reperfusion Injury; Sodium-Hydrogen Exchangers; Time Factors | 2005 |
KCa+ channels contribute to exercise-induced coronary vasodilation in swine.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Exercise Test; Female; Glyburide; Hypoglycemic Agents; Male; Oxygen Consumption; Physical Conditioning, Animal; Physical Exertion; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Sus scrofa; Tetraethylammonium; Time Factors; Vasodilation | 2006 |
KATP channel openers of the benzopyran type reach their binding site via the cytosol.
Topics: Benzopyrans; Cell Line; Cytosol; Dihydropyridines; Humans; Potassium Channels | 2006 |
Dose-related shortening of ventricular tachycardia cycle length after administration of the KATP channel opener bimakalim in a 4-day-old chronic infarct anesthetized pig model.
Topics: Action Potentials; Anesthesia, General; Animals; Anti-Arrhythmia Agents; Benzopyrans; Cardiac Pacing, Artificial; Chronic Disease; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart Rate; Infusions, Intravenous; KATP Channels; Male; Myocardial Infarction; Myocardium; Refractory Period, Electrophysiological; Swine; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation | 2009 |
Proarrhythmic effects of aldosterone during myocardial ischemia-reperfusion: implication of the sarcolemmal-KATP channels.
Topics: Action Potentials; Aldosterone; Animals; Benzopyrans; Dihydropyridines; Disease Models, Animal; Female; Glyburide; Heart Ventricles; In Vitro Techniques; KATP Channels; Male; Myocardial Reperfusion Injury; Perfusion; Rabbits; Sarcolemma | 2014 |