Page last updated: 2024-09-05

bifeprunox and clozapine

bifeprunox has been researched along with clozapine in 7 studies

Compound Research Comparison

Studies
(bifeprunox)
Trials
(bifeprunox)
Recent Studies (post-2010)
(bifeprunox)
Studies
(clozapine)
Trials
(clozapine)
Recent Studies (post-2010) (clozapine)
301129,6917473,148

Protein Interaction Comparison

ProteinTaxonomybifeprunox (IC50)clozapine (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)0.14
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.6
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.032
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.47
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.476
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.045
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.1233
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.1534
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.15
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.031
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.013
Alpha-2A adrenergic receptorHomo sapiens (human)0.09
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.14
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0096
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)2
D(2) dopamine receptorHomo sapiens (human)0.2044
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0886
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0567
Alpha-2B adrenergic receptorHomo sapiens (human)0.023
Alpha-2C adrenergic receptorHomo sapiens (human)0.0079
DRattus norvegicus (Norway rat)1.066
D(3) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.2695
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)3.5772
D(2) dopamine receptorBos taurus (cattle)1.804
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.078
D(1A) dopamine receptorHomo sapiens (human)0.107
D(4) dopamine receptorHomo sapiens (human)0.0796
Adenylate cyclase type 3Rattus norvegicus (Norway rat)0.14
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0567
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.47
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)5.7544
Histamine H2 receptorHomo sapiens (human)3.61
Alpha-1D adrenergic receptorHomo sapiens (human)0.035
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.9312
Adenylate cyclase type 2Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 4Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.373
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.587
D(4) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.587
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0338
Histamine H1 receptorRattus norvegicus (Norway rat)0.023
Sodium-dependent serotonin transporterHomo sapiens (human)0.546
5-hydroxytryptamine receptor 2C Mus musculus (house mouse)0.028
5-hydroxytryptamine receptor 2AMus musculus (house mouse)0.028
Histamine H1 receptorHomo sapiens (human)0.0049
D(3) dopamine receptorHomo sapiens (human)0.354
Adenylate cyclase type 8Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.081
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0567
5-hydroxytryptamine receptor 6Homo sapiens (human)0.0171
D(2) dopamine receptorMus musculus (house mouse)0.29
D(2) dopamine receptorRattus norvegicus (Norway rat)0.6759
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.6
5-hydroxytryptamine receptor 2BMus musculus (house mouse)0.028
Adenylate cyclase type 6Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 5Rattus norvegicus (Norway rat)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4162
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.6
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.6
5-hydroxytryptamine receptor 1AMus musculus (house mouse)2
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)0.14
DBos taurus (cattle)4.09

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Moes, J; Feenstra, RW; Hofma, JJ; Kling, H; Kruse, CG; Kuipers, W; Long, SK; Tulp, MT; van der Heyden, JA1
Antonio, CB; Barreiro, EJ; Fraga, CA; Grazziottin, LR; Menegatti, R; Neves, G; Noël, F; Rates, SM; Vieira, RO1
Assié, MB; Carilla-Durand, E; Cosi, C; Leduc, N; Maraval, M; Newman-Tancredi, A; Ormiere, AM1
Dekeyne, A; Iob, L; Millan, MJ; Péglion, JL1
Corsini, GU; Maggio, R; Millan, MJ; Novi, F1
Aliaga, M; Assié, MB; Barbara, M; Bardin, L; Carilla-Durand, E; Malfètes, N; Maraval, M; Newman-Tancredi, A1
Auclair, AL; Barret-Grévoz, C; Barreto, M; Depoortère, R; Kleven, MS; Newman-Tancredi, A1

Other Studies

7 other study(ies) available for bifeprunox and clozapine

ArticleYear
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
    Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzoxazoles; Dopamine Antagonists; Drug Design; Drug Evaluation, Preclinical; Mice; Piperazines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship

2001
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
    Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5

    Topics: Administration, Oral; Animals; Antipsychotic Agents; Cell Line; Humans; Ligands; Male; Mice; Piperazines; Pyrazoles; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Schizophrenia

2010
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
    European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes

2006
Discriminative stimulus properties of S32504, a novel D3/D2 receptor agonist and antiparkinson agent, in rats: attenuation by the antipsychotics, aripiprazole, bifeprunox, N-desmethylclozapine, and by selective antagonists at dopamine D2 but not D3 recept
    Psychopharmacology, 2007, Volume: 191, Issue:3

    Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Benzoxazoles; Clozapine; Discrimination Learning; Discrimination, Psychological; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Oxazines; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3

2007
Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation.
    Journal of neurochemistry, 2007, Volume: 102, Issue:4

    Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzoxazoles; Carrier Proteins; Chlorocebus aethiops; Clozapine; COS Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Piperazines; Piperidines; Quinolones; Receptors, Dopamine D2; Receptors, Dopamine D3; Transfection

2007
The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Benzofurans; Benzoxazoles; Benzylamines; Blood Glucose; Clozapine; Corticosterone; Cyclopentanes; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Olanzapine; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Thiazoles

2008
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
    Behavioural brain research, 2009, Nov-05, Volume: 203, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording

2009