bifeprunox and 8-hydroxy-2-(di-n-propylamino)tetralin
bifeprunox has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 4 studies
*8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. [MeSH]
*8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. [MeSH]
Compound Research Comparison
| Studies (bifeprunox) | Trials (bifeprunox) | Recent Studies (post-2010) (bifeprunox) | Studies (8-hydroxy-2-(di-n-propylamino)tetralin) | Trials (8-hydroxy-2-(di-n-propylamino)tetralin) | Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin) |
|---|---|---|---|---|---|
| 30 | 1 | 12 | 3,530 | 7 | 389 |
Protein Interaction Comparison
| Protein | Taxonomy | bifeprunox (IC50) | 8-hydroxy-2-(di-n-propylamino)tetralin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.0012 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0032 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 0.8 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 2.8959 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.0021 |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bourdiol, N; Colpaert, F; Cuisiat, S; Lacharme, V; Newman-Tancredi, A; Vacher, B | 1 |
| Assié, MB; Faucillon, V; Newman-Tancredi, A; Ravailhe, V | 1 |
| Assié, MB; Carilla-Durand, E; Cosi, C; Leduc, N; Maraval, M; Newman-Tancredi, A; Ormiere, AM | 1 |
| Auclair, AL; Barret-Grévoz, C; Barreto, M; Depoortère, R; Kleven, MS; Newman-Tancredi, A | 1 |
Other Studies
4 other study(ies) available for bifeprunox and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Benzylamines; Dopamine D2 Receptor Antagonists; HeLa Cells; Humans; Radioligand Assay; Rats; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Stereoisomerism; Structure-Activity Relationship | 2007 |
Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzoxazoles; Dopamine; Hippocampus; Male; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin | 2005 |
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes | 2006 |
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording | 2009 |